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EVALUATION OF SERUM VITAMIN D LEVELS ACCORDING TO SEASON, AGE, AND GENDER IN MARDIN PROVINCE AND ITS SURROUNDINGS

Year 2022, Volume: 8 Issue: 2, 84 - 90, 31.12.2022
https://doi.org/10.51477/mejs.1055186

Abstract

Vitamin D is a steroid in character and a fat-soluble vitamin. It is produced primarily from cholesterol in the skin and is also taken up in a small amount in the diet. 25(OH)D3 levels are used as an indirect measure of vitamin D levels. Our aim was to investigate the variation in serum 25(OH)D3 levels of patients admitted to the hospital in and around Mardin based on gender, season, and age. 25(OH)D3 concentrations were evaluated at Mardin Training and Research Hospital between 01.01.2017 and 01.01.2020. Our study established subgroups according to gender, season, age, and 25(OH)D3 status. 25(OH)D3 concentration was measured using the chemiluminescence method. A significant decrease was observed in the 25(OH)D3 levels of female (13.62±11.53 ng/ml) patients compared to male patients (12.14±9.38 ng/ml).. A significant increase was detected in the summer and autumn seasons compared to winter and spring (p<0.001). There was no significant difference between age and serum 25(OH)D3 concentration. 25(OH)D3 status was shown to be 60.5% in the severe deficiency group. As a result, it has been shown that the vitamin D profile in Mardin and its surroundings is low in all seasons and in all age groups. For this reason, consuming food sources rich in vitamin D and taking supplements indicate that the importance of sunlight in vitamin D metabolism should be emphasized.

References

  • Holick, M.F., “Sunlight and vitamin D for bone health and prevention of autoimmune diseases cancers, and cardiovascular disease”, The American Journal of Clinical Nutrition, 80(6), 1678-88, 2004. Doi: 10.1093/ajcn/80.6.1678S.
  • Holick, M.F., “Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis”, The American Journal of Clinical Nutrition, 79(3), 362–71, 2004. Doi: 10.1093/ajcn/79.3.362.
  • Holick, M.F., “Vitamin D deficiency”, The New England Journal of Medicine, 357(3), 266–81, 2007. Doi: 10.1056/NEJMra070553.
  • Jenab, M., et al., “Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case–control study”, British Medical Journal, 340:b5500, 2010. Doi: 10.1016/j.maturitas.2009.12.013.
  • Parker, J., Hashmi, O., Dutton, D., Mavrodaris, A., Stranges, S., Kandala, N.B., Clarke, A., Franco, OH., “Levels of vitamin D and cardiometabolic disorders: systematic review andmeta-analysis”, Maturitas, 65(3), 225–36, 2010. Doi: 10.1016/j.maturitas.2009.12.013.
  • Munger, K.L.,, Levin. L.I., Hollis, B.W., Howard. N.S., Ascherio, A., “Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis”, The Journal of the American Medical Association, 296(23), 2832–2838, 2006. Doi: 10.1001/jama.296.23.2832.
  • Newmark, H.L., Newmark. J., “Vitamin D and Parkinson’s disease a hypothesis”, Movement Disorders, 22(4), 461–468, 2007. Doi: 10.1002/mds.21317.
  • Trump, D.L., Deeb, K.K., Johnson, C.S., “Vitamin D: considerations in the continued development as an agent for cancer prevention and therapy”, Cancer Journal, 16(1), 1–9, 2010. Doi: 10.1097/PPO.0b013e3181c51ee6.
  • Ritterhouse, L.L,., Lu, R., Shah, H.B., Robertson, J.M., Fife, D.A., Maecker, H.T., Du, H., Fathman, C.G., Chakravarty, E.F., Scofield, R.H., Kamen, D.L., Guthridge, J.M., James, J.A., “ Vitamin D deficiency in a multi ethnic healthy control cohort and altered immune response in vitamin D deficient European-American healthy controls”, Plos One, 9(4), e94500, 2014. Doi: 10.1371/journal.pone.0094500. eCollection 2014.
  • World Health Organization. “Vitamin and mineral requirements in human nutrition”, 2nd ed. Geneva, World Health Organization, 2005.
  • Ross, A.C., Taylor, C.L., Yaktine, A.L., Del Valle, H.B., editors. “Dietary Reference Intakes for calcium and vitamin. Committee to Review Dietary Reference Intakes for Vitamin D and Calcium”, Institute of Medicine Washington, DC: National Academies Press, 2010.
  • Misra, M., Pacaud, D., Petryk, A., Collett-Solberg, P.F., Kappy, M., Drug and therapeutics committee of the Lawson Wilkins pediatric endocrine society. “Vitamin D deficiency in children and its management: review of current knowledge and recommendations”, Pediatrics, 122(2), 398e417, 2008. Doi: 10.1542/peds.2007-1894.
  • Adams, J.S., Hewison, M., “Update in vitamin D”, The Journal of Clinical Endocrinology & Metabolism, 5(2), 471-8, 2010. Doi: 10.1210/jc.2009-1773.
  • Christakos, S., Dhawan, P., Verstuyf., A., Verlinden, L., Carmeliet, G., “Vitamin D: metabolism, molecular mechanism of action, and Pleiotropic Effects”, Physiological Reviews, 96(1), 365–408, 2016. Doi: 10.1152/physrev.00014.2015
  • Canadian Agency for Drugs and Technologies in Health. “Vitamin D Testing in the General Population: A Review of the Clinical and Cost-Effectiveness and Guidelines”, Ottawa (ON); 2015.
  • Deeb, K.K., Trump, D.L., Johnson, C., “Vitamin D signalling pathways in cancer: potential for anticancer therapeutics”, Nature Reviews Cancer, 7(9), 684–700, 2007. Doi: 10.1038/nrc2196.
  • Bouillon, R., Eelen, G., Verlinden, L., Mathieu, C., Carmeliet, G., Verstuyf, A., “Vitamin D and cancer”, The Journal of Steroid Biochemistry and Molecular Biology, 102(1-5), 156–62, 2006. Doi: 10.1016/j.jsbmb.2006.09.014
  • Prietl, B., Treiber, G., Pieber, T.R., Amrein, K., “Vitamin D and immune function”, Nutrients, 5(7), 2502–21, 2013. doi: 10.3390/nu5072502.
  • Bolland, M.J., Grey, A.B., Ames, R.W., Mason, B.H., Horne, A.M., Gamble, G.D., Reid, I.R.. The effects of seasonal variation of 25-hydroxyvitamin D and fat mass on a diagnosis of vitamin D sufficiency”, The American Journal of Clinical Nutrition, 86(4), 959-64, 2007. Doi: 10.1093/ajcn/86.4.959.
  • Vuceljić, M., Ilić-Stojanović, O., Lazović, M., Grajić, M., “Vitamin D and parathyroid hormone in relation to bone mineral density in postmenopausal women”, Vojnosanitetski pregled, 69(3), 243-8, 2012. Doi: 10.2298/VSP1203243V
  • Van der Wielen, R.P., Löwik, M.R., Van den Berg, H., de Groot, L.C., Haller, J., Moreiras, O., van Staveren, W.A., “Serum vitamin D concentrations among elderly people in Europe”, Lancet, 22, 346(8969), 207-10, 1995. Doi: 10.1016/s0140-6736(95)91266-5.
  • Alayunt, N.Ö., Özüdoğru, O., “Siirt bölgesinde D vitamini seviyesinin yaş, cinsiyet ve mevsimlere göre değişimi”, Turk Journal Osteoporos, 26(3), 160-164, 2020. Doi: 10.4274/tod.galenos.2020.37233
  • Taşkıran, B., Cansu, G.B., “Güneydoğu Bölgesinde erişkinlerde D vitamini eksikliği”, Osmangazi Tıp Dergisi, 39(1), 13-20, 2017. Doi:.10.20515/otd.52389
  • Çubukçu, M., Acı, R., Müderrisoğlu, S., “Samsun İlinde D vitamini düzeylerinin yaş, cinsiyet ve mevsimsel özelliklere göre değerlendirilmesi”, Ankara Medical Journal, (4):769-75, 2019. Doi: 10.17098/amj. 652002
  • Telo, S., Kaman, D., Akgöl, G., “Elazığ İlinde D vitamini düzeylerinin yaş, cinsiyet ve mevsimlere göre değişimi”, Fırat Tıp Dergisi, 22(1), 29-33, 2017.
  • Mardin ilinin meteorolojik durumu, https://www.mardintso.org.tr/mardin/cografyasi/
  • Guzel, R., Kozanoglu, E., Guler-Uysal, F., Soyupak, S., Sarpel, T., “Vitamin D status and bone mineral density of veiled and unveiled Turkish women”, Journal of Women's Health & Gender-Based Medicine, 10(8), 765-70, 2001. Doi: 10.1089/15246090152636523.
  • Çolak, A.A., Doğan, N., Bozkurt, Ü., Avcı, R., Karademirci, İ,. “Vitamin D status in women in İzmir”, Tepecik Eğitim ve Araştırma Hastanesi Dergisi, 25(1), 38-42, 2015. Doi: 10.5222/terh.2015.038
  • Balaharoglu, R., Cokluk, E., Alp, H.H., Üçler, R., Şekeroğlu, M.R., Huyut, Z., “Evaluation of seasonal relationship with vitamin D levels in Van region”, Acta Medica Alanya, 3(2), 124-128, 2019. Doi: 10.30565/medalanya.463904
Year 2022, Volume: 8 Issue: 2, 84 - 90, 31.12.2022
https://doi.org/10.51477/mejs.1055186

Abstract

Thanks

MARDİN İL SAĞLIK MÜDÜRLÜĞÜ VE MARDİN EĞİTİM VE ARAŞTIRMA HASTANESİ BİLGİ İŞLEM MEREKZİNE TEŞEKKÜR EDERİZ.

References

  • Holick, M.F., “Sunlight and vitamin D for bone health and prevention of autoimmune diseases cancers, and cardiovascular disease”, The American Journal of Clinical Nutrition, 80(6), 1678-88, 2004. Doi: 10.1093/ajcn/80.6.1678S.
  • Holick, M.F., “Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis”, The American Journal of Clinical Nutrition, 79(3), 362–71, 2004. Doi: 10.1093/ajcn/79.3.362.
  • Holick, M.F., “Vitamin D deficiency”, The New England Journal of Medicine, 357(3), 266–81, 2007. Doi: 10.1056/NEJMra070553.
  • Jenab, M., et al., “Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case–control study”, British Medical Journal, 340:b5500, 2010. Doi: 10.1016/j.maturitas.2009.12.013.
  • Parker, J., Hashmi, O., Dutton, D., Mavrodaris, A., Stranges, S., Kandala, N.B., Clarke, A., Franco, OH., “Levels of vitamin D and cardiometabolic disorders: systematic review andmeta-analysis”, Maturitas, 65(3), 225–36, 2010. Doi: 10.1016/j.maturitas.2009.12.013.
  • Munger, K.L.,, Levin. L.I., Hollis, B.W., Howard. N.S., Ascherio, A., “Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis”, The Journal of the American Medical Association, 296(23), 2832–2838, 2006. Doi: 10.1001/jama.296.23.2832.
  • Newmark, H.L., Newmark. J., “Vitamin D and Parkinson’s disease a hypothesis”, Movement Disorders, 22(4), 461–468, 2007. Doi: 10.1002/mds.21317.
  • Trump, D.L., Deeb, K.K., Johnson, C.S., “Vitamin D: considerations in the continued development as an agent for cancer prevention and therapy”, Cancer Journal, 16(1), 1–9, 2010. Doi: 10.1097/PPO.0b013e3181c51ee6.
  • Ritterhouse, L.L,., Lu, R., Shah, H.B., Robertson, J.M., Fife, D.A., Maecker, H.T., Du, H., Fathman, C.G., Chakravarty, E.F., Scofield, R.H., Kamen, D.L., Guthridge, J.M., James, J.A., “ Vitamin D deficiency in a multi ethnic healthy control cohort and altered immune response in vitamin D deficient European-American healthy controls”, Plos One, 9(4), e94500, 2014. Doi: 10.1371/journal.pone.0094500. eCollection 2014.
  • World Health Organization. “Vitamin and mineral requirements in human nutrition”, 2nd ed. Geneva, World Health Organization, 2005.
  • Ross, A.C., Taylor, C.L., Yaktine, A.L., Del Valle, H.B., editors. “Dietary Reference Intakes for calcium and vitamin. Committee to Review Dietary Reference Intakes for Vitamin D and Calcium”, Institute of Medicine Washington, DC: National Academies Press, 2010.
  • Misra, M., Pacaud, D., Petryk, A., Collett-Solberg, P.F., Kappy, M., Drug and therapeutics committee of the Lawson Wilkins pediatric endocrine society. “Vitamin D deficiency in children and its management: review of current knowledge and recommendations”, Pediatrics, 122(2), 398e417, 2008. Doi: 10.1542/peds.2007-1894.
  • Adams, J.S., Hewison, M., “Update in vitamin D”, The Journal of Clinical Endocrinology & Metabolism, 5(2), 471-8, 2010. Doi: 10.1210/jc.2009-1773.
  • Christakos, S., Dhawan, P., Verstuyf., A., Verlinden, L., Carmeliet, G., “Vitamin D: metabolism, molecular mechanism of action, and Pleiotropic Effects”, Physiological Reviews, 96(1), 365–408, 2016. Doi: 10.1152/physrev.00014.2015
  • Canadian Agency for Drugs and Technologies in Health. “Vitamin D Testing in the General Population: A Review of the Clinical and Cost-Effectiveness and Guidelines”, Ottawa (ON); 2015.
  • Deeb, K.K., Trump, D.L., Johnson, C., “Vitamin D signalling pathways in cancer: potential for anticancer therapeutics”, Nature Reviews Cancer, 7(9), 684–700, 2007. Doi: 10.1038/nrc2196.
  • Bouillon, R., Eelen, G., Verlinden, L., Mathieu, C., Carmeliet, G., Verstuyf, A., “Vitamin D and cancer”, The Journal of Steroid Biochemistry and Molecular Biology, 102(1-5), 156–62, 2006. Doi: 10.1016/j.jsbmb.2006.09.014
  • Prietl, B., Treiber, G., Pieber, T.R., Amrein, K., “Vitamin D and immune function”, Nutrients, 5(7), 2502–21, 2013. doi: 10.3390/nu5072502.
  • Bolland, M.J., Grey, A.B., Ames, R.W., Mason, B.H., Horne, A.M., Gamble, G.D., Reid, I.R.. The effects of seasonal variation of 25-hydroxyvitamin D and fat mass on a diagnosis of vitamin D sufficiency”, The American Journal of Clinical Nutrition, 86(4), 959-64, 2007. Doi: 10.1093/ajcn/86.4.959.
  • Vuceljić, M., Ilić-Stojanović, O., Lazović, M., Grajić, M., “Vitamin D and parathyroid hormone in relation to bone mineral density in postmenopausal women”, Vojnosanitetski pregled, 69(3), 243-8, 2012. Doi: 10.2298/VSP1203243V
  • Van der Wielen, R.P., Löwik, M.R., Van den Berg, H., de Groot, L.C., Haller, J., Moreiras, O., van Staveren, W.A., “Serum vitamin D concentrations among elderly people in Europe”, Lancet, 22, 346(8969), 207-10, 1995. Doi: 10.1016/s0140-6736(95)91266-5.
  • Alayunt, N.Ö., Özüdoğru, O., “Siirt bölgesinde D vitamini seviyesinin yaş, cinsiyet ve mevsimlere göre değişimi”, Turk Journal Osteoporos, 26(3), 160-164, 2020. Doi: 10.4274/tod.galenos.2020.37233
  • Taşkıran, B., Cansu, G.B., “Güneydoğu Bölgesinde erişkinlerde D vitamini eksikliği”, Osmangazi Tıp Dergisi, 39(1), 13-20, 2017. Doi:.10.20515/otd.52389
  • Çubukçu, M., Acı, R., Müderrisoğlu, S., “Samsun İlinde D vitamini düzeylerinin yaş, cinsiyet ve mevsimsel özelliklere göre değerlendirilmesi”, Ankara Medical Journal, (4):769-75, 2019. Doi: 10.17098/amj. 652002
  • Telo, S., Kaman, D., Akgöl, G., “Elazığ İlinde D vitamini düzeylerinin yaş, cinsiyet ve mevsimlere göre değişimi”, Fırat Tıp Dergisi, 22(1), 29-33, 2017.
  • Mardin ilinin meteorolojik durumu, https://www.mardintso.org.tr/mardin/cografyasi/
  • Guzel, R., Kozanoglu, E., Guler-Uysal, F., Soyupak, S., Sarpel, T., “Vitamin D status and bone mineral density of veiled and unveiled Turkish women”, Journal of Women's Health & Gender-Based Medicine, 10(8), 765-70, 2001. Doi: 10.1089/15246090152636523.
  • Çolak, A.A., Doğan, N., Bozkurt, Ü., Avcı, R., Karademirci, İ,. “Vitamin D status in women in İzmir”, Tepecik Eğitim ve Araştırma Hastanesi Dergisi, 25(1), 38-42, 2015. Doi: 10.5222/terh.2015.038
  • Balaharoglu, R., Cokluk, E., Alp, H.H., Üçler, R., Şekeroğlu, M.R., Huyut, Z., “Evaluation of seasonal relationship with vitamin D levels in Van region”, Acta Medica Alanya, 3(2), 124-128, 2019. Doi: 10.30565/medalanya.463904
There are 29 citations in total.

Details

Primary Language English
Subjects Biochemistry and Cell Biology (Other)
Journal Section Article
Authors

Ahmet Dündar 0000-0003-0527-189X

Publication Date December 31, 2022
Submission Date January 8, 2022
Acceptance Date November 7, 2022
Published in Issue Year 2022 Volume: 8 Issue: 2

Cite

IEEE A. Dündar, “EVALUATION OF SERUM VITAMIN D LEVELS ACCORDING TO SEASON, AGE, AND GENDER IN MARDIN PROVINCE AND ITS SURROUNDINGS”, MEJS, vol. 8, no. 2, pp. 84–90, 2022, doi: 10.51477/mejs.1055186.