AbstractEffect of Environmental Lead on Intrinsic Biomechanical Properties of Cortical Bone Objective: This study aimed to investigate the effects of low dose lead on the biomechanical properties of cortical bone. Method: 10 week-old Sprague–Dawley male and female rats were assigned randomly to a control group and experimental group (n=20, 10 male and 10 female for each group). The experimental rats were treated by gavage (per os) with 100mg/kg lead acetate dissolved in saline once per week for 10 weeks. Bone mineral density (BMD) was measured at mid-diaphysis femoral region using by dual energy X-ray absorbsiometry. Cross-sectional area of the femoral shaft was evaluated by computerized tomography. Biomechanical measurements were performed at the mid-diaphysis of the left femur. Stress, strain and toughness were measured in all rats. Results: No significant differences were observed between control and experimental groups for biomechanical properties of cortical bone. Conclusion: The results of the present study indicate that low dose lead acetate administration did not change bone quality. Gender differences also did not change the effect of lead on the intrinsic properties of rat cortical bone.
Türkçe Özet:Amaç: Bu çalışmada çevresel kurşunun, kortikal kemiğin intrinsik biyomekanik özellikleri üzerine etkisinin incelenmesi hedeflendi. Yöntem: 10 haftalık Sprague–Dawley dişi ve erkek sıçanlar kontrol ve deney grubu olmak üzere rastgele iki gruba ayrıldı (n=20, her grupta 10 erkek, 10 dişi). Deney grubundaki sıçanlara 10 hafta boyunca 100mg/kg dozunda kurşun asetat gavajla uygulandı. Kemik mineral yoğunluğu (KMY) çift enerjili X ışınları absorbsiyometrisi ile kortikal femurun kesit alanı ise bilgisayarlı tomografiyle ölçüldü. Biyomekanik ölçümler sol femur diafizinde gerçekleştirildi. Tüm sıçanlarda stres, strain ve dayanıklılık ölçüldü. Bulgular: Kortikal kemik biyomekanik parametreleri açısından kontrol grubuyla deney grubu arasında istatistiksel olarak önemli bir fark gözlenmedi. Sonuç: Bu çalışma sonucunda düşük doz kurşunun kemiğin intrinsik biyomekanik kalitesini değiştirmediği ve cinsiyet farklılığının da kemiğin intrinsik biyomekanik özelliklerinde herhangi bir etkisi olmadığı gözlendi.
Primary Language | Turkish |
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Journal Section | Articles |
Authors | |
Publication Date | March 1, 2008 |
Submission Date | June 13, 2014 |
Published in Issue | Year 2008 Volume: 1 Issue: 1 |
MEU Journal of Health Sciences Assoc was began to the publishing process in 2008 under the supervision of Assoc. Prof. Gönül Aslan, Editor-in-Chief, and affiliated to Mersin University Institute of Health Sciences. In March 2015, Prof. Dr. Caferi Tayyar Şaşmaz undertook the Editor-in Chief position and since then he has been in charge.
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