Türkçe Özet: Amaç: Dokuların yeterli oksijenlenmesi için hemoglobin konsantrasyonu önemlidir. Hemoglobin düzeylerindeki düşüklükler dokuların radyosensitivitesini azaltıyor olabilir. Çalışmada ileri evre kanser olgularında hemoglobin düzeylerinin, öncellikle radyoterapi veya radyoterapi+kemoterapiye verilen yanıtla ilişkisinin olup olmadığının gösterilmesi amaçlandı. Yöntem: Mayıs 1997-Mayıs 1998 tarihleri arasında Çukurova Üniversitesi Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı\'nda radyoterapi uygulanan ileri evre 61 olguda hemoglobin düzeylerinin radyoterapi veya radyoterapi+kemoterapiye verilen yanıt ilişkisi prospektif olarak değerlendirildi. Hemoglobin düzeylerinin ölçümleri, tedavinin başlangıcında (I. kontrol), ortasında (II. kontrol), bitiminde (III. kontrol) ve tedaviden sonraki 3. ayda (IV. kontrol) yapıldı. Bulgular: Primer tümör ve lenfatik metastazlarına Co 60 cihazıyla radyoterapi verilen olgularda tedaviye yanıt oranı %27.8 idi. Olgulardan %11.4'ünde tam yanıt, %16.4'ünde kısmi yanıt, %47.6'sında stabil hastalık, %24.6'sında ilerleme saptandı. Olguların 25'ine kemoterapi ve radyoterapi birlikte uygulandı (%40.9). Tedavi yanıtlarına göre gruplar arasında hemoglobin düzeyleri açısından farklılık anlamlı bulundu (p<0.001). Tam yanıt+kısmi yanıt grubu ve stabil hastalık grubu ile ilerleme gösteren grup arasında hemoglobin düzeyleri açısından farklılık anlamlı bulundu (p<0.001). Sonuç: Aneminin, artmış lokal rekürrens ve kısalmış sürvi oranları ile birlikte olduğu belirlendi. Kanserli olgularda radyoterapi veya radyoterapi+kemoterapi uygulanırken aneminin izlenmesinin ve düzeltilmesinin tedavi etkinliğini artırabileceği düşünüldü.
AbstractRelationship of Haemoglobin Levels with Response to Radiotherapy and Chemotherapy in Advanced Cancer Cases Aim: Haemoglobin concentration is important for sufficient oxygenisation of tissues. Low levels of haemoglobin might decrease radiosensitivity of tissues. In this study, it was primarily aimed to evaluate a potential relationship between haemoglobin levels and response to the radiotherapy or the combined treatment with radiotherapy + chemotherapy in advanced cancer cases. Methods: Relationship among haemoglobin levels with response to radiotherapy or radiotherapy+chemotherapy were evaluated prospectively in 61 advanced cancer cases at Çukurova University, Medical School, Department of Radiation Oncology from May 1997 to May 1998. Measurement of haemoglobin levels were performed in the beginning (lst control), in the middle (2nd control), in the end of the therapy (3rd control) and 3 months after the therapy (4th control). Results: Response to therapy rate of cases which had radiotherapy with Co 60 for primary tumor and lymphatic metastases were 27.8%. It is found that complete response in 11.4%, partial response in 16.4%, stable in 47.6% and progression in 24.6% of cases. Chemotherapy and radiotherapy performed to 25 of cases (40.9%). As regarding responses to the therapy, differences in haemoglobin levels between groups were found significant (p<0.001). Conclusion: It was determined that anemia is associated with increased local recurrens and shortened survey rates. It was suggested that monitoring and improvement of anemia during the radiotherapy or the combination treatment of radiotherapy with chemotherapy in cancer cases might improve the efficiency of the treatment.
Primary Language | Turkish |
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Journal Section | Articles |
Authors | |
Publication Date | March 1, 2011 |
Submission Date | June 13, 2014 |
Published in Issue | Year 2011 Volume: 4 Issue: 1 |
MEU Journal of Health Sciences Assoc was began to the publishing process in 2008 under the supervision of Assoc. Prof. Gönül Aslan, Editor-in-Chief, and affiliated to Mersin University Institute of Health Sciences. In March 2015, Prof. Dr. Caferi Tayyar Şaşmaz undertook the Editor-in Chief position and since then he has been in charge.
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