Abstract
Abstract Pustular Drug Eruption Associated with Hydorxyurea, Hydroxyurea (HU), an antitumor agent, has been used for treatment of chronic myeloproliferative disorders. Although HU is usually well-tolerated, several cutaneous changes have been reported during long-term HU therapy. In this case report, the development of pustular drug eruption was presented, following a long term hydroxyurea therapy in a 83 year-old-male with essential thrombo-sitosis.
Keywords
References
- Warnock JK, Morris DW. Adverse cutaneous reactions to antidepressants. Am J Clin Dermatol 2002;3(1):329-39. Revuz J. New advances in severe adverse drug reactions. Dermatol Clin 2001;19(45):697-709.
- Mengesha YM, Bennett ML. Pustular Skin Disorders. Diagnosis and Treatment. Am J Clin Dermatol 2002;3(5):389-400.
- Kwah YC, Leow YH. Not all pustules are infective in nature: acute generalised exanthematous pustulosis causing pustular eruptions in an elderly woman. Singapore MedJ2005;46(l):349-51.
- DeLeo VA. Skin testing in systemic cutaneous drug reactions. Lancet 1998;352(33):1488-90.
- Roychowdhury S, Svensson CK. Mechanisms of drug- induced delayed-type hypersensitivity reactions in the skin. American Association of Pharmaceutical Scientists Journal 2005;7(4):834-46.
- Vassallo C, Passamonti F, Merante S, Ardigo M, Nolli G, Mangiacavalli S, Borroni G. Mucocutaneous changes during long-term therapy With hydroxyurea in chronic myeloid leukemia. Clin Exp Dermatol 2001 ;26(1 3): 141 -8. 11. Kumar B, Saraswat A, Kaur I. Mucocutaneous adverse effects of hydroxyurea: a prospective study of 30 psoriasis
- patients. Clin Exp Dermatol 2002;27(1):8-13.
- Young HS, Khan AS, Kendra JR, Coulson IH. The cutaneous side-effects of hydroxyurea. Clin Lab Haemaiol 2000;22(89):229-32.
Abstract
Türkçe Özet: Hidroksiüre antitümör bir ajan olup kronik miyeloproliferatif hastalıkların tedavisinde kullanılmak-tadır. Hidroksiüre genellikle iyi tolere edilmesine karşın uzun dönem tedavide bazı deri değişikliklerine yol açabilmektedir. Bu olguda 83 yaşında bir erkek hastada esansiyel trombositoz nedeniyle uzun dönem hidroksiüre tedavisinden sonra püstüler ilaç erüpsiyonu gelişimi bildirildi.
Keywords
References
- Warnock JK, Morris DW. Adverse cutaneous reactions to antidepressants. Am J Clin Dermatol 2002;3(1):329-39. Revuz J. New advances in severe adverse drug reactions. Dermatol Clin 2001;19(45):697-709.
- Mengesha YM, Bennett ML. Pustular Skin Disorders. Diagnosis and Treatment. Am J Clin Dermatol 2002;3(5):389-400.
- Kwah YC, Leow YH. Not all pustules are infective in nature: acute generalised exanthematous pustulosis causing pustular eruptions in an elderly woman. Singapore MedJ2005;46(l):349-51.
- DeLeo VA. Skin testing in systemic cutaneous drug reactions. Lancet 1998;352(33):1488-90.
- Roychowdhury S, Svensson CK. Mechanisms of drug- induced delayed-type hypersensitivity reactions in the skin. American Association of Pharmaceutical Scientists Journal 2005;7(4):834-46.
- Vassallo C, Passamonti F, Merante S, Ardigo M, Nolli G, Mangiacavalli S, Borroni G. Mucocutaneous changes during long-term therapy With hydroxyurea in chronic myeloid leukemia. Clin Exp Dermatol 2001 ;26(1 3): 141 -8. 11. Kumar B, Saraswat A, Kaur I. Mucocutaneous adverse effects of hydroxyurea: a prospective study of 30 psoriasis
- patients. Clin Exp Dermatol 2002;27(1):8-13.
- Young HS, Khan AS, Kendra JR, Coulson IH. The cutaneous side-effects of hydroxyurea. Clin Lab Haemaiol 2000;22(89):229-32.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | June 1, 2012 |
| Submission Date | June 13, 2014 |
| Published in Issue | Year 2012 Volume: 5 Issue: 2 |
Cite
MEU Journal of Health Sciences Assoc was began to the publishing process in 2008 under the supervision of Assoc. Prof. Gönül Aslan, Editor-in-Chief, and affiliated to Mersin University Institute of Health Sciences. In March 2015, Prof. Dr. Caferi Tayyar Şaşmaz undertook the Editor-in Chief position and since then he has been in charge.
Publishing in three issues per year (April - August - December), it is a multisectoral refereed scientific journal. In addition to research articles, scientific articles such as reviews, case reports and letters to the editor are published in the journal. Our journal, which has been published via e-mail since its inception, has been published both online and in print. Following the Participation Agreement signed with TÜBİTAK-ULAKBİM Dergi Park in April 2015, it has started to accept and evaluate online publications.
Mersin University Journal of Health Sciences have been indexed by Turkey Citation Index since November 16, 2011.
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