Abstract
Abstract A Case Report: Anticonvulsant Hypersensitive Syndrome Anticonvulsant hypersensitivity syndrome is a complication of antiepileptic medications. The syndrome is characterized with triad of fever, rash, and symptomatic or asymptomatic internal organ involvement, including primarily hepatitis, nephritis, and lymphadenopathy. In this paper, a severe case of carbamazepine-induced hypersensitivity syndrome was reported.
References
- Scheuerman 0, Moses YN, Rachmel A, Ashkenazi S. Successful treatment of antiepileptic drug hypersensitivity syndrome with intravenous immune globulin. Pediatrics 2001;107(l):1-2.
- Kaur S, Sarkar R, Thami GP, Kanwar AJ. Anticonvulsant hypersensitivity syndrome. Pediatr Dermatol 2002;l9(2): 142-5.
- Shear NH, Speilberg SP. Anticonvulsant hypersensitivity syndrome: in vitro assessment of risk. J Clin Invest 1988;82 (6):1826-32.
- Speilberg SP, Gordon GB, Blake DA, Mellitus DE, Bross DS. Anticonvulsant toxicity in vitro. Possible role of arene oxides. JPharmacol Exp Ther l981;217(2):386-9.
- Sim E, Pinter K, Mushtag A, Upton A, Sandy J, Bhakta S, Noble M. Arylamine N-acetyltransferases: a pharmacoge- nomic approach to drug metabolism and endogenous function. Biochem Soc Trans 2003;3 1 (Pt 3):615-9.
- Ateş NA, Tursen U, Tamer L, Kanik A, Derici E, Ercan B, Atik U. Glutathione S-transferase polymorphisms in patients with drug eruption. Arch Dermatol Res 2004;295(10):429-33.
- Tassies D, Freire C, Pijoan J, Maragall S, Monteaqudo J, Ordinas A, Reverter JC. Pharmacogenetics of acenocouma- rol: cytochrome P450 CYP2C9 polimorphisms influence dose requirements and stability of anticoagulation. Heamatologia 2002;87(l l):1185-91.
- Konishi T, Naganuma Y, Hongo K, Murakami M, Yamanati M, Okada T. Carbamazepine-induced skin rash in children with epilepsy. Eur J Pediatr 1993; 152(7):605-8.
- Garavelli PL, Azzini M. Skin rash induced by carbamazepine. Descriptin of 2 clinical cases. Minerva Med 1990;81(7-8):115-6.
- Syndrome Associated with Glutathione S-Transferase, N— Acetyltransferase, Cytochrome P450 Polymorphisms. J TurkAcad Dermatol 2012;6(3):1263c2
Abstract
Türkçe Özet: Antikolvülzan hipersensitivite sendromu antiepileptik ilaçların bir komplikasyonudur. Bu sendrom ateş, döküntü ve hepatit, nefrit gibi semptomatik veya asemptomatik iç organ tutulum bulguları ve lenfadenopati triadı ile karakterizedir. Burada şiddetli, karbamazepinle indüklenen hipersensitivite sendromlu bir olgu sunmaktayız.
References
- Scheuerman 0, Moses YN, Rachmel A, Ashkenazi S. Successful treatment of antiepileptic drug hypersensitivity syndrome with intravenous immune globulin. Pediatrics 2001;107(l):1-2.
- Kaur S, Sarkar R, Thami GP, Kanwar AJ. Anticonvulsant hypersensitivity syndrome. Pediatr Dermatol 2002;l9(2): 142-5.
- Shear NH, Speilberg SP. Anticonvulsant hypersensitivity syndrome: in vitro assessment of risk. J Clin Invest 1988;82 (6):1826-32.
- Speilberg SP, Gordon GB, Blake DA, Mellitus DE, Bross DS. Anticonvulsant toxicity in vitro. Possible role of arene oxides. JPharmacol Exp Ther l981;217(2):386-9.
- Sim E, Pinter K, Mushtag A, Upton A, Sandy J, Bhakta S, Noble M. Arylamine N-acetyltransferases: a pharmacoge- nomic approach to drug metabolism and endogenous function. Biochem Soc Trans 2003;3 1 (Pt 3):615-9.
- Ateş NA, Tursen U, Tamer L, Kanik A, Derici E, Ercan B, Atik U. Glutathione S-transferase polymorphisms in patients with drug eruption. Arch Dermatol Res 2004;295(10):429-33.
- Tassies D, Freire C, Pijoan J, Maragall S, Monteaqudo J, Ordinas A, Reverter JC. Pharmacogenetics of acenocouma- rol: cytochrome P450 CYP2C9 polimorphisms influence dose requirements and stability of anticoagulation. Heamatologia 2002;87(l l):1185-91.
- Konishi T, Naganuma Y, Hongo K, Murakami M, Yamanati M, Okada T. Carbamazepine-induced skin rash in children with epilepsy. Eur J Pediatr 1993; 152(7):605-8.
- Garavelli PL, Azzini M. Skin rash induced by carbamazepine. Descriptin of 2 clinical cases. Minerva Med 1990;81(7-8):115-6.
- Syndrome Associated with Glutathione S-Transferase, N— Acetyltransferase, Cytochrome P450 Polymorphisms. J TurkAcad Dermatol 2012;6(3):1263c2
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | June 1, 2013 |
| Submission Date | June 13, 2014 |
| Published in Issue | Year 2013 Volume: 6 Issue: 2 |
Cite
MEU Journal of Health Sciences Assoc was began to the publishing process in 2008 under the supervision of Assoc. Prof. Gönül Aslan, Editor-in-Chief, and affiliated to Mersin University Institute of Health Sciences. In March 2015, Prof. Dr. Caferi Tayyar Şaşmaz undertook the Editor-in Chief position and since then he has been in charge.
Publishing in three issues per year (April - August - December), it is a multisectoral refereed scientific journal. In addition to research articles, scientific articles such as reviews, case reports and letters to the editor are published in the journal. Our journal, which has been published via e-mail since its inception, has been published both online and in print. Following the Participation Agreement signed with TÜBİTAK-ULAKBİM Dergi Park in April 2015, it has started to accept and evaluate online publications.
Mersin University Journal of Health Sciences have been indexed by Turkey Citation Index since November 16, 2011.
Mersin University Journal of Health Sciences have been indexed by ULAKBIM Medical Database from the first issue of 2016.
Mersin University Journal of Health Sciences have been indexed by DOAJ since October 02, 2019.
Article Publishing Charge Policy: Our journal has adopted an open access policy and there is no fee for article application, evaluation, and publication in our journal. All the articles published in our journal can be accessed from the Archive free of charge.
This work is licensed with Attribution-NonCommercial 4.0 International.