Abstract
References
- BuscaA, KumarA. Innate immune responses in hepatitis B virus (HBV) infection. Viral J 2014; 1 1 :22.
- Fernan A, Cayzer CJR, Cooksley GE. HBsAg-induced antigen speciŞc T and B lymphocyte responses in chronic hepatitis B virus carriers and immune individuals. Clin Exp Immunal 1989;76(2):222-6.
- Wang J, Cai Y, Ji H, Feng J, Ayana DA, Niu J, Jiang Y. Serum IL-33 levels are associated with liver damage in patients with chronic hepatitis B. J Interferon Cytokine Res 2012;32(6):248-53.
- Ye Y, Xie X, Yu J, Zhou L, Xie H, Jiang G, Yu X, Zhang W, Wu ], Zheng S. Involvement of Th17 and Thl effect or responses in patients With Hepatitis B. J Clin Immuno] 2010;30(4):546-55.
- Das A, Maini MK. Innate and adaptive immune responses in hepatitis B Virus infection. Dig Dis 2010;28(1):126-32.
- Shaiia S, Dilafroze, Sofi FA, Rasool R, J aveed S, Shah ZA. Rheumatoid arthritis and genetic variations in cytokine genes: a population-based study in Kashmir Valley. Immu- nol Invest 2014;43(4):349-59.
- Birbian N, Singh J, Jindal SK, Sobti RC. High risk association of IL-4 VNTR polymorphism with asthma in a North Indian population. Cytokine 2014;66(1):87-94.
- Warle' MC, Farhan A, Metselaar HJ, Hop WC, Perrey C, Zondervan PE, Kap M, Kwekkeboom J, Ijzermans JN, Tilanus HW, Pravica V, Hutchinson IV, Bouma GJ. Are cytokine gene polymorphisms related to in Vitro cytokine production proŞles? Liver Transpl 2003;9(2):170-81.
- Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H. Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev 2001;12(1):53-72
- Bertoletti A, D'Elios MM, Boni C, De Carli M, Zignego
- AL, Durazzo M, Missale G, Penna A, Fiaccadori F, Del
- Maini MK, Boni C, Ogg GS, King AS, Reignat S, Lee CK, Larrubia JR, Webster GJ , McMichael AJ, Ferrari C, Williams R, Vergani D, Bertoletti A. Direct ex vivo analy- sis of hepatitis B virus-specific CD8(+) T cells associated With the control of infection. Gastroenterology 1999;117 (6):1386-96.
- Thimme R, Wieland S, Steiger C, Ghrayeb J, Reimann KA, Purcell RH, Chisari FV. CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J Vırol 2003;77(1):68-76.
- Kemal Celen M, Tekin Koruk S, Aygen B, Dal T, Karabay 0, Tosun S, Koksal I, Turgut H, Onlen Y, Balik I, Yildirim N, Sinan Dal M, Ayaz C, Tabak F. The characteristics of patients with chronic hepatitis B in Turkey. Med Glas (Zenica) 2014;11(1):94-8.
- PennaA, Del Prete G, Cavalli A, Bertoletti A, D'Elios MM, Sorrentino R, D'Amato M, Boni C, Pilli M, Fiaccadori F, Ferrari C. Predominant T-helper 1 cytokine proŞle of hepatitis B virus nucleocapsid-speciŞc T cells in acute self- limited hepatitis B. Hepatology 1997;25(4):1022-7.
- McGuinness PH, Painter D, Davies S, McCaughan GW. Increases in intrahepatic CD68 positive cells, MAC387 positive cells, and proinşammatory cytokines (particularly interleukin 18) in chronic hepatitis C infection. Gut 2000; 46(2):260-9.
- Kimura K, Kakimi K, Wieland S, Guidotti LG, Chisari FV. Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice. J Vırol 2002;76(21):10702-7.
- Giedraitis V, He B, Huang WX, Hillert J. Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation. J Neuro- immunol2001;112(1-2):146-52.
- Wen D, Liu J, Du X, Dong JZ, Ma CS. Association of Interleukin-18 (-137G/C) Polymorphism with Rheumatoid Arthritis and Systemic Lupus Erythematosus: A Meta-Analysis. Int Rev Immuno 2014;33(1):34-44.
- Tavares NA, Santos MM, Moura R, Araujo J, Guimarâes R,
- Crovella S, Brandâo L. Interleukin 18 (IL18) gene
- Bouzgarrou N, Hassen E, Schvoerer E, Stall-Keller F,
- Bahri O, Gabbouj S, Cheikh I, Maamouri N, Mammi N,
- Migita K, Miyazoe S, Maeda Y, Daikoku M, Abiru S, Ueki
- T, Yano K, Nagaoka S, Matsumoto T, Nakao K, Hamasaki
- K, Yatsuhashi H, Ishibashi H, Eguchi K. Cytokine gene
- polymorphisms in Japanese patients with hepatitis B virus
- infection--association between TGF-betal polymorp
- hisms and hepatocellular carcinoma. J Hepatol 2005;42(4) :505-10.
- Zhang PA, Wu JM, Li Y, Yang XS. Association of
- polymorphisms of interleukin-18 gene promoter region
- Hirankam N, Manonom C, Tangkijvanich P, Poovorawan
- Y. Association of interleukin-18 gene polymorphism (
- A/A genotype) with susceptibility to chronic hepatitis
- B virus infection. Tissue Antigens 2007;70(2):160-3.
Abstract
Amaç: Hepatit B virus (HBV) enfeksiyonu ve enfeksiyonu takiben ortaya çıkan patolojik değişimler oldukça ciddi sonuçları olan global bir sağlık sorunudur. IL18, HBV gibi enfeksiyöz organizmalara karşı immun sistemin regülasyonunda oldukça önemli rol oynayan bir sitokindir. Yapılan son çalışmalar IL18 genindeki varyasyonların IL18 gen ekspresyonunu etkilediğini göstermiştir. Bu çalışmada IL18 gen polimorfizmleri (rs1946518, rs187238) ile kronik HBV enfeksiyonu arasındaki ilişki araştırılmıştır.
Yöntem: Kronik hepatit B hastası olan 113 birey ve kontrol grubu olarak seçilen 71 bireyin IL18 gen polimorfizmi polimeraz zincir reaksiyonu-restriksiyon parça uzunluk polimorfizmi (PCR-RFLP) yöntemi kullanılarak belirlenmiştir.
Bulgular: IL18 -137 G/C polimorfizmi için genotip frekansları hasta grubunda GG, GC ve CC genotipleri sırasıyla %33.6, %50.4 ve %15.9 kontrol grubunda ise %32.0, %46.5 ve %18.3 olarak saptanmıştır. IL18 -607 C/A polimorfizmi için ise CC, CA ve AA genotip frekansları hasta grubunda %55.8, %34.5 ve %9.7; kontrol grubunda ise %62, %31 ve %7 olarak bulunmuştur. IL18 polimorfizmlerinin genotip dağılımlarının gruplar arasında istatistiksel açıdan anlamlı bir farklılık göstermediği tespit edilmiştir (sırasıyla p=0.66, p=0.85).
Sonuç: Elde edilen bu sonuçlar IL18 gen -137 G/C and -607 C/A gene polimorfizmi ile kronik Hepatit B arasında anlamlı bir ilişki olmadığını göstermektedir. Ancak daha büyük ölçekli çalışmalar IL-18 -137 G/C and -607 C/A gene polimorfizminin kronik hepatit B patogenezinin anlaşılmasında faydalı olabilir.
Keywords
References
- BuscaA, KumarA. Innate immune responses in hepatitis B virus (HBV) infection. Viral J 2014; 1 1 :22.
- Fernan A, Cayzer CJR, Cooksley GE. HBsAg-induced antigen speciŞc T and B lymphocyte responses in chronic hepatitis B virus carriers and immune individuals. Clin Exp Immunal 1989;76(2):222-6.
- Wang J, Cai Y, Ji H, Feng J, Ayana DA, Niu J, Jiang Y. Serum IL-33 levels are associated with liver damage in patients with chronic hepatitis B. J Interferon Cytokine Res 2012;32(6):248-53.
- Ye Y, Xie X, Yu J, Zhou L, Xie H, Jiang G, Yu X, Zhang W, Wu ], Zheng S. Involvement of Th17 and Thl effect or responses in patients With Hepatitis B. J Clin Immuno] 2010;30(4):546-55.
- Das A, Maini MK. Innate and adaptive immune responses in hepatitis B Virus infection. Dig Dis 2010;28(1):126-32.
- Shaiia S, Dilafroze, Sofi FA, Rasool R, J aveed S, Shah ZA. Rheumatoid arthritis and genetic variations in cytokine genes: a population-based study in Kashmir Valley. Immu- nol Invest 2014;43(4):349-59.
- Birbian N, Singh J, Jindal SK, Sobti RC. High risk association of IL-4 VNTR polymorphism with asthma in a North Indian population. Cytokine 2014;66(1):87-94.
- Warle' MC, Farhan A, Metselaar HJ, Hop WC, Perrey C, Zondervan PE, Kap M, Kwekkeboom J, Ijzermans JN, Tilanus HW, Pravica V, Hutchinson IV, Bouma GJ. Are cytokine gene polymorphisms related to in Vitro cytokine production proŞles? Liver Transpl 2003;9(2):170-81.
- Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H. Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev 2001;12(1):53-72
- Bertoletti A, D'Elios MM, Boni C, De Carli M, Zignego
- AL, Durazzo M, Missale G, Penna A, Fiaccadori F, Del
- Maini MK, Boni C, Ogg GS, King AS, Reignat S, Lee CK, Larrubia JR, Webster GJ , McMichael AJ, Ferrari C, Williams R, Vergani D, Bertoletti A. Direct ex vivo analy- sis of hepatitis B virus-specific CD8(+) T cells associated With the control of infection. Gastroenterology 1999;117 (6):1386-96.
- Thimme R, Wieland S, Steiger C, Ghrayeb J, Reimann KA, Purcell RH, Chisari FV. CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J Vırol 2003;77(1):68-76.
- Kemal Celen M, Tekin Koruk S, Aygen B, Dal T, Karabay 0, Tosun S, Koksal I, Turgut H, Onlen Y, Balik I, Yildirim N, Sinan Dal M, Ayaz C, Tabak F. The characteristics of patients with chronic hepatitis B in Turkey. Med Glas (Zenica) 2014;11(1):94-8.
- PennaA, Del Prete G, Cavalli A, Bertoletti A, D'Elios MM, Sorrentino R, D'Amato M, Boni C, Pilli M, Fiaccadori F, Ferrari C. Predominant T-helper 1 cytokine proŞle of hepatitis B virus nucleocapsid-speciŞc T cells in acute self- limited hepatitis B. Hepatology 1997;25(4):1022-7.
- McGuinness PH, Painter D, Davies S, McCaughan GW. Increases in intrahepatic CD68 positive cells, MAC387 positive cells, and proinşammatory cytokines (particularly interleukin 18) in chronic hepatitis C infection. Gut 2000; 46(2):260-9.
- Kimura K, Kakimi K, Wieland S, Guidotti LG, Chisari FV. Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice. J Vırol 2002;76(21):10702-7.
- Giedraitis V, He B, Huang WX, Hillert J. Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation. J Neuro- immunol2001;112(1-2):146-52.
- Wen D, Liu J, Du X, Dong JZ, Ma CS. Association of Interleukin-18 (-137G/C) Polymorphism with Rheumatoid Arthritis and Systemic Lupus Erythematosus: A Meta-Analysis. Int Rev Immuno 2014;33(1):34-44.
- Tavares NA, Santos MM, Moura R, Araujo J, Guimarâes R,
- Crovella S, Brandâo L. Interleukin 18 (IL18) gene
- Bouzgarrou N, Hassen E, Schvoerer E, Stall-Keller F,
- Bahri O, Gabbouj S, Cheikh I, Maamouri N, Mammi N,
- Migita K, Miyazoe S, Maeda Y, Daikoku M, Abiru S, Ueki
- T, Yano K, Nagaoka S, Matsumoto T, Nakao K, Hamasaki
- K, Yatsuhashi H, Ishibashi H, Eguchi K. Cytokine gene
- polymorphisms in Japanese patients with hepatitis B virus
- infection--association between TGF-betal polymorp
- hisms and hepatocellular carcinoma. J Hepatol 2005;42(4) :505-10.
- Zhang PA, Wu JM, Li Y, Yang XS. Association of
- polymorphisms of interleukin-18 gene promoter region
- Hirankam N, Manonom C, Tangkijvanich P, Poovorawan
- Y. Association of interleukin-18 gene polymorphism (
- A/A genotype) with susceptibility to chronic hepatitis
- B virus infection. Tissue Antigens 2007;70(2):160-3.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | May 5, 2015 |
| Submission Date | May 5, 2015 |
| Published in Issue | Year 2014 Volume: 7 Issue: 1 |
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MEU Journal of Health Sciences Assoc was began to the publishing process in 2008 under the supervision of Assoc. Prof. Gönül Aslan, Editor-in-Chief, and affiliated to Mersin University Institute of Health Sciences. In March 2015, Prof. Dr. Caferi Tayyar Şaşmaz undertook the Editor-in Chief position and since then he has been in charge.
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