Pentraksinler

Year 2017, Volume: 10 Issue: 1, 65 - 71, 13.04.2017

Nilay Günaştı Şenay Balcı Lülüfer Tamer

Abstract

Pentraksinler evrimsel olarak korunmuş olan bir protein ailesidir. Pentraksinler alt biriminin birincil yapısına göre kısa ve uzun pentraksinler olarak iki gruba ayrılır. Gen organizasyonunu, kromozom lokalizasyonunu ve ligand-tanıma yeteneğine uzun ve kısa pentraksinler farklılık gösterebilirler. Kısa pentraksinlerden C-reaktif protein ve serum amiloid P bileşeni çoğunlukla interlökin-6’ nın uyarılması ile karaciğerden sentezlenir. Uzun pentraksinlerin ilk olarak keşfedilen en önemli üyesi olan Pentraksin-3, endotelyal hücreler ve fibroblastlarda bir sitokin ile uyarılabilir bir gen olarak sentezlenir. Bu derlemede, özellikle pentraksin-3 olmak üzere pentraksin ailesi üyelerinin özellikleri ve yapısı ile ilgili bilgilerin aktarılması amaçlanmaktadır.

Anahtar Sözcükler: pentraksin-3, kısa pentraksinler, uzun pentraksinler

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