Abstract
Amaç: Bu çalışmada kolin
klorür içeren bazı alçak ötektik çözücülerin karakterizasyonlarının
gerçekleştirilmesi ve antibakteriyel aktivitelerinin belirlenmesi amaçlandı. Yöntem: Çalışılan dört farklı alçak
ötektik çözücünün iletkenlik değerleri tespit edildi. Fourier dönüşümlü
infrared spektroskopisi ve proton nükleer manyetik rezonans spektroskopisi ile
karakterizasyon işlemleri gerçekleştirildi. Antibakteriyel aktivite tayinininde
Resazurin mikroplak yöntemi kullanıldı. Bulgular:
Alçak ötektik çözücülerin yapıları spektroskopik yöntemler ile aydınlatıldı.
Alçak ötektik çözücülerin ampisiline göre daha düşük antibakteriyel aktivite
gösterdiği bulundu. Sonuç: Alçak
ötektik çözücülerin ilaç endüstrisindeki ilgi uyandıran uygulamaları dikkate
alındığında çalışmanın daha fazla sayıda alçak ötektik çözücünün
fizikokimyasal, antibakteriyel ve sitotoksik özelliklerinin araştırılmasıyla
genişletebileceği sonucuna varıldı.
References
- KaynaklarReferans 1. Radošević K, Bubalo MC, Srček VG, Grgas D, Dragičević TL, Redovniković I R. Evaluation of toxicity and biodegradability of choline chloride based deep eutectic solvents. ECOTOXİCOL ENVİRON SAF 2015; 112: 46–53.Referans 2. Abbott AP, Capper G, Davies DL, Rasheed Raymond K, Tambyrajah V. Novel solvent properties of choline chloride/urea mixtures. CHEM. COMMUN 2003; 70–71.Referans 3. Abbott AP, Boothby D, Capper G, Davies DL, Rasheed RK. Deep Eutectic Solvents Formed between Choline Chloride and Carboxylic Acids: Versatile Alternatives to Ionic Liquids. J. AM. CHEM. SOC. 2004; 126: 9142-9147.Referans 4. Abbott AP, Capper G, McKenzie KJ, Ryder KS. Electrodeposition of zinc–tin alloys from deep eutectic solvents based on choline chloride. J. ELECTROANAL. CHEM 2007; 599: 288–294.Referans 5. Abo-Hamad A, Hayyan M, AlSaadi MA, Hashim MA. Potential applications of deep eutectic solvents in nanotechnology. CHEM. ENG. J. 2015; 273: 551–567.Referans 6. Tang B, Row KH. Recent developments in deep eutectic solvents in chemical sciences. MONATSH CHEM 2013; (144):1427–1454. Referans 7. Wena Q, Chen J X, Tang YL, Wang J , Yang Z. Assessing the toxicity and biodegradability of deep eutectic solvents. CHEMOSPHERE 2015; 132: 63–69.Referans 8. Morrisona HG, Sunb CC, Neervannan S. Characterization of thermal behavior of deep eutectic solvents and their potential as drug solubilization vehicles. INT. J. PHARM. 2009; 378: 136–139.Referans 9. Chen J, Wang Q, Liu M, Zhang L. The effect of deep eutectic solvent on the pharmacokinetics of salvianolic acid B in rats and its acute toxicity test. J. CHROMATOGR. B 2017; 1063: 60–66.Referans 10. Abbott AP, Ahmed EI, Prasad K, Qader IB, Ryder KS. Liquid pharmaceuticals formulation by eutectic formation. FLUİD PHASE EQUİLİB. 2014; 448: 2-8.Referans 11. Gahlaut A, Chhillar AK. Evaluation of Antibacterial Potential of Plant Extracts Using Resazurin Based Microtiter Dilution Assay. INT J PHARM PHARM SCİ. 2013;5(2):372-376.Referans 12. CLSI. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard-Ninth Edition. CLSI document M07-A9. Wayne, PA: Clinical and Laboratory Standards Institute; 2012.
Abstract
References
- KaynaklarReferans 1. Radošević K, Bubalo MC, Srček VG, Grgas D, Dragičević TL, Redovniković I R. Evaluation of toxicity and biodegradability of choline chloride based deep eutectic solvents. ECOTOXİCOL ENVİRON SAF 2015; 112: 46–53.Referans 2. Abbott AP, Capper G, Davies DL, Rasheed Raymond K, Tambyrajah V. Novel solvent properties of choline chloride/urea mixtures. CHEM. COMMUN 2003; 70–71.Referans 3. Abbott AP, Boothby D, Capper G, Davies DL, Rasheed RK. Deep Eutectic Solvents Formed between Choline Chloride and Carboxylic Acids: Versatile Alternatives to Ionic Liquids. J. AM. CHEM. SOC. 2004; 126: 9142-9147.Referans 4. Abbott AP, Capper G, McKenzie KJ, Ryder KS. Electrodeposition of zinc–tin alloys from deep eutectic solvents based on choline chloride. J. ELECTROANAL. CHEM 2007; 599: 288–294.Referans 5. Abo-Hamad A, Hayyan M, AlSaadi MA, Hashim MA. Potential applications of deep eutectic solvents in nanotechnology. CHEM. ENG. J. 2015; 273: 551–567.Referans 6. Tang B, Row KH. Recent developments in deep eutectic solvents in chemical sciences. MONATSH CHEM 2013; (144):1427–1454. Referans 7. Wena Q, Chen J X, Tang YL, Wang J , Yang Z. Assessing the toxicity and biodegradability of deep eutectic solvents. CHEMOSPHERE 2015; 132: 63–69.Referans 8. Morrisona HG, Sunb CC, Neervannan S. Characterization of thermal behavior of deep eutectic solvents and their potential as drug solubilization vehicles. INT. J. PHARM. 2009; 378: 136–139.Referans 9. Chen J, Wang Q, Liu M, Zhang L. The effect of deep eutectic solvent on the pharmacokinetics of salvianolic acid B in rats and its acute toxicity test. J. CHROMATOGR. B 2017; 1063: 60–66.Referans 10. Abbott AP, Ahmed EI, Prasad K, Qader IB, Ryder KS. Liquid pharmaceuticals formulation by eutectic formation. FLUİD PHASE EQUİLİB. 2014; 448: 2-8.Referans 11. Gahlaut A, Chhillar AK. Evaluation of Antibacterial Potential of Plant Extracts Using Resazurin Based Microtiter Dilution Assay. INT J PHARM PHARM SCİ. 2013;5(2):372-376.Referans 12. CLSI. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard-Ninth Edition. CLSI document M07-A9. Wayne, PA: Clinical and Laboratory Standards Institute; 2012.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Articles |
| Authors | |
| Publication Date | August 15, 2018 |
| Submission Date | March 16, 2018 |
| Acceptance Date | May 14, 2018 |
| Published in Issue | Year 2018 Volume: 11 Issue: 2 |
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MEU Journal of Health Sciences Assoc was began to the publishing process in 2008 under the supervision of Assoc. Prof. Gönül Aslan, Editor-in-Chief, and affiliated to Mersin University Institute of Health Sciences. In March 2015, Prof. Dr. Caferi Tayyar Şaşmaz undertook the Editor-in Chief position and since then he has been in charge.
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