Aralıklı açlık uygulamalarının vücut bileşimi ve biyokimyasal parametreler üzerine etkisi: Bir literatür derlemesi

Özge Mengi Çelik; Eda Köksal

doi:10.26559/mersinsbd.708821

Review

Aralıklı açlık uygulamalarının vücut bileşimi ve biyokimyasal parametreler üzerine etkisi: Bir literatür derlemesi

Year 2020, Volume: 13 Issue: 2, 249 - 271, 26.08.2020

Özge Mengi Çelik Eda Köksal

Abstract

Son dönemlerde popüler bir konu haline gelen aralıklı açlık uygulamaları, alternatif bir enerji kısıtlama yöntemidir. ‘Zaman kısıtlı beslenme’, ‘alternatif gün açlığı’, ‘5:2 diyet’ ve ‘ramazan açlığı’ literatürde en sık kullanılan açlık protokolleridir. Yapılan çalışmalarda, bu uygulamaların obezite, insülin direnci, dislipidemi, hipertansiyon, inflamasyon, diyabet, kardiyovasküler hastalıklar, kanser ve nörodejeneratif hastalıklarda etkili olabileceği üzerinde durulmaktadır. Günümüzde aralıklı açlık uygulamaları için yapılan sağlık önerileri daha çok hayvan çalışmalarından elde edilen sonuçlara dayanmaktadır. İnsan çalışmalarından elde edilen veriler, bu uygulamaların vücut bileşimi, kan lipitleri, glukoz ve insülin düzeyleri, inflamatuar sitokinler, açlık-tokluk hormonları ve kan basıncı üzerine olumlu etkilerinin olabileceğini desteklemektedir. Ancak, toplumda beslenme açısından yüksek risk grubu olan kronik hastalığı olan bireyler, gebe ve emziren kadınlar, küçük çocuklar ve yaşlı bireyler açlık uygulamalarının yan etkileri açısından risk altındadır ve açlık uygulamaktan kaçınmalıdır. Sağlıklı popülasyonda ve kronik hastalığı olan bireylerde aralıklı açlık uygulamalarının etkilerinin açığa kavuşturulması için uzun süreli sağlık sonuçlarını değerlendiren araştırmalara ihtiyaç vardır. Bu derlemede aralıklı açlık uygulamalarının vücut bileşimi ve biyokimyasal parametreler üzerine olan etkisi insan çalışmaları ile irdelenmiştir.

Keywords

aralıklı açlık, vücut bileşimi, biyokimyasal parametreler

References

1. World Health Organization. Obesity and overweight. Erişim yeri: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight, Erişim Tarihi: 24.03.2020.
2. Templeman I, Gonzalez JT. The role of intermittent fasting and meal timing in weight management and metabolic health. Proc Nutr Soc 2019:1-12.
3. Tinsley GM, La Bounty PM. Effects of intermittent fasting on body composition and clinical health markers in humans. Nutr Rev 2015;73(10):661-74.
4. Patterson RE, Sears DD. Metabolic Effects of Intermittent Fasting. Annu Rev Nutr 2017;37:371-93.
5. Rothschild J, Hoddy KK, Jambazian P, Varady KA. Time-restricted feeding and risk of metabolic disease: a review of human and animal studies. Nutr Rev 2014;72(5):308-18.
6. Varady KA, Hellerstein MK. Do calorie restriction or alternate-day fasting regimens modulate adipose tissue physiology in a way that reduces chronic disease risk? Nutr Rev 2008;66(6):333-42.
7. Harvie MN, Pegington M, Mattson MP, Frystyk J, Dillon B, Evans G, Cuzick J, Jebb SA, Martin B, Cutler RG, Son TG, Maudsley S, Carlson OD, Egan JM, Flyvbjerg A, Howell A. The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women. Int J Obes (Lond) 2011;35(5):714-27.
8. Nugraha B, Ghashang SK, Hamdan I, Gutenbrunner C. Effect of Ramadan fasting on fatigue, mood, sleepiness, and health-related quality of life of healthy young men in summer time in Germany: A prospective controlled study. Appetite 2017;111:38-45.
9. Horne BD, Muhlestein JB, Anderson JL. Health effects of intermittent fasting: hormesis or harm? A systematic review. Am J Clin Nutr 2015;102(2):464-70.
10. Harris L, Hamilton S, Azevedo LB, Olajide J, De Brun C, Waller G. Intermittent fasting interventions for treatment of overweight and obesity in adults: a systematic review and meta-analysis. JBI Database System Rev Implement Rep 2018;16(2):507-47.
11. Malinowski B, Zalewska K, Wesierska A, Sokolowska MM, Socha M, Liczner G. Intermittent Fasting in Cardiovascular Disorders-An Overview. Nutrients 2019;11(3).
12. Paoli A, Tinsley G. The Influence of Meal Frequency and Timing on Health in Humans: The Role of Fasting. Nutrients 2019;11(4).
13. de Cabo R, Mattson MP. Effects of Intermittent Fasting on Health, Aging, and Disease. N Engl J Med 2019;381(26):2541-51.
14. Moro T, Tinsley G. Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males. J Transl Med 2016;14(1):290.
15. Carter S, Clifton PM, Keogh JB. The effects of intermittent compared to continuous energy restriction on glycaemic control in type 2 diabetes; a pragmatic pilot trial. Diabetes Res Clin Pract 2016;122:106-12.
16. Conley M, Le Fevre L, Haywood C, Proietto J. Is two days of intermittent energy restriction per week a feasible weight loss approach in obese males? A randomised pilot study. Nutr Diet 2018;75(1):65-72.
17. Sundfor TM, Svendsen M, Tonstad S. Effect of intermittent versus continuous energy restriction on weight loss, maintenance and cardiometabolic risk: A randomized 1-year trial. Nutr Metab Cardiovasc Dis 2018;28(7):698-706.
18. Khazneh E, Qaddumi J, Hamdan Z, Qudaimat F, Sbitany A, Jebrin K, Sawalmeh O, Abuiram Y, Shraim M. The effects of Ramadan fasting on clinical and biochemical markers among hemodialysis patients: A prospective cohort study. PloS one 2019;14(6).
19. Einollahi B, Shahyad S, Lotfiazar A. Re: Clinical and Biochemical Parameters of Hemodialysis Patients before and during the Islamic Ramadan Month. Iran J Kidney Dis 2017;11(2):168.
20. Imtiaz S, Salman B, Dhrolia MF, Nasir K, Abbas HN, Ahmad A. Clinical and Biochemical Parameters of Hemodialysis Patients Before and During Islamic Month of Ramadan. Iran J Kidney Dis 2017;11(2):168. 2016;10(2):75-8.
21. Alshamsi S, Binsaleh F, Hejaili F, Karkar A, Moussa D, Raza H, et Parbat P, Al Suwida A, Alobaili S, AlSehli R, Al Sayyari A. Changes in biochemical, hemodynamic, and dialysis adherence parameters in hemodialysis patients during Ramadan. Hemodial Int 2016;20(2):270-6.
22. Yeoh EC, Zainudin SB, Loh WN, Chua CL, Fun S, Subramaniam T, Sum CF, Lim SC. Fasting during Ramadan and Associated Changes in Glycaemia, Caloric Intake and Body Composition with Gender Differences in Singapore. Ann Acad Med Singapore 2015;44(6):202-6.
23. Mattson MP, Moehl K, Ghena N, Schmaedick M, Cheng A. Intermittent metabolic switching, neuroplasticity and brain health. Nat Rev Neurosci 2018;19(2):63.
24. Swindell WR. Dietary restriction in rats and mice: a meta-analysis and review of the evidence for genotype-dependent effects on lifespan. Ageing Res Rev 2012;11(2):254-70.
25. Nencioni A, Caffa I, Cortellino S, Longo VD. Fasting and cancer: molecular mechanisms and clinical application. Nat Rev Cancer 2018;18(11):707.
26. Corley BT, Carroll RW, Hall RM, Weatherall M, Parry-Strong A, Krebs JD. Intermittent fasting in Type 2 diabetes mellitus and the risk of hypoglycaemia: a randomized controlled trial. Diabet Med 2018;35(5):588-94.
27. Carter S, Clifton PM, Keogh JB. Effect of Intermittent Compared With Continuous Energy Restricted Diet on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Noninferiority Trial. JAMA Netw Open 2018;1(3):e180756.
28. Parvaresh A, Razavi R, Abbasi B, Yaghoobloo K, Hassanzadeh A, Mohammadifard N. Modified alternate-day fasting vs. calorie restriction in the treatment of patients with metabolic syndrome: A randomized clinical trial. Complement Ther Med 2019;47:102187.
29. O’Flanagan CH, Smith LA, McDonell SB, Hursting SD. When less may be more: calorie restriction and response to cancer therapy. BMC Med 2017;15(1):106.
30. Rohm M, Zeigerer A, Machado J, Herzig S. Energy metabolism in cachexia. EMBO Rep 2019;20(4).
31. Wlodarek D. Role of Ketogenic Diets in Neurodegenerative Diseases (Alzheimer's Disease and Parkinson's Disease). Nutrients 2019;11(1).
32. Grajower MM, Horne BD. Clinical Management of Intermittent Fasting in Patients with Diabetes Mellitus. Nutrients 2019;11(4).
33. Gabel K, Hoddy KK, Haggerty N, Song J, Kroeger CM, Trepanowski JF, Panda S, Varady KA. Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: A pilot study. Nutr Healthy Aging 2018;4(4):345-53.
34. LeCheminant JD, Christenson E, Bailey BW, Tucker LA. Restricting night-time eating reduces daily energy intake in healthy young men: a short-term cross-over study. Br J Nutr 2013;110(11):2108-13.
35. Catenacci VA, Pan Z, Ostendorf D, Brannon S, Gozansky WS, Mattson MP, Martin B, MacLean PS, Melanson EL, Troy Donahoo W. A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity. Obesity (Silver Spring) 2016;24(9):1874-83.
36. Unalacak M, Kara IH, Baltaci D, Erdem O, Bucaktepe PG. Effects of Ramadan fasting on biochemical and hematological parameters and cytokines in healthy and obese individuals. Metab Syndr Relat Disord 2011;9(2):157-61.
37. Santos HO, Macedo RCO. Impact of intermittent fasting on the lipid profile: Assessment associated with diet and weight loss. Clin Nutr ESPEN 2018;24:14-21.
38. Longo VD, Mattson MP. Fasting: molecular mechanisms and clinical applications. Cell Metab 2014;19(2):181-92.
39. Golbidi S, Daiber A, Korac B, Li H, Essop MF, Laher I. Health Benefits of Fasting and Caloric Restriction. Curr Diab Rep 2017;17(12):123.
40. Sutton EF, Beyl R, Early KS, Cefalu WT, Ravussin E, Peterson CM. Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. Cell Metab 2018;27(6):1212-21.e3.
41. Tinsley GM, Forsse JS, Butler NK, Paoli A, Bane AA, La Bounty PM, Morgan GB, Grandjean PW. Time-restricted feeding in young men performing resistance training: A randomized controlled trial. Eur J Sport Sci 2017;17(2):200-7.
42. Kesztyus D, Cermak P, Gulich M, Kesztyus T. Adherence to Time-Restricted Feeding and Impact on Abdominal Obesity in Primary Care Patients: Results of a Pilot Study in a Pre-Post Design. Nutrients 2019;11(12).
43. Varady KA, Hellerstein MK. Alternate-day fasting and chronic disease prevention: a review of human and animal trials. Am J Clin Nutr 2007;86(1):7-13.
44. M S, Ah SA, Sr S, Km B. Effect of Ramadan Fasting on Body Weight, (BP) and Biochemical Parameters in Middle Aged Hypertensive Subjects: An Observational Trial. J Clin Diagn Res 2014;8(3):16-8.
45. Nachvak SM, Pasdar Y, Pirsaheb S, Darbandi M, Niazi P, Mostafai R, Speakman JR. Effects of Ramadan on food intake, glucose homeostasis, lipid profiles and body composition composition. Eur J Clin Nutr 2019;73(4):594-600.
46. Lopez-Bueno M, Gonzalez-Jimenez E, Navarro-Prado S, Montero-Alonso MA, Schmidt-RioValle J. Influence of age and religious fasting on the body composition of Muslim women living in a westernized context. Nutr Hosp 2014;31(3):1067-73.
47. Kiyani MM, Memon AR, Amjad MI, Ameer MR, Sadiq M, Mahmood T. Study of Human Biochemical Parameters During and After Ramadan. J Relig Health 2017;56(1):55-62.
48. Harder-Lauridsen NM, Rosenberg A, Benatti FB, Damm JA, Thomsen C, Mortensen EL, Pedersen BK, Krogh-Madsen R. Ramadan model of intermittent fasting for 28 d had no major effect on body composition, glucose metabolism, or cognitive functions in healthy lean men. Nutrition 2017;37:92-103.
49. Rohin MA, Rozano N, Abd Hadi N, Mat Nor MN, Abdullah S, Dandinasivara Venkateshaiah M. Anthropometry and body composition status during Ramadan among higher institution learning centre staffs with different body weight status. ScientificWorldJournal 2013;2013:308041.
50. Ongsara S, Boonpol S, Prompalad N, Jeenduang N. The Effect of Ramadan Fasting on Biochemical Parameters in Healthy Thai Subjects. J Clin Diagn Res 2017;11(9):Bc14-bc8.
51. Al-Barha NS, Aljaloud KS. The Effect of Ramadan Fasting on Body Composition and Metabolic Syndrome in Apparently Healthy Men. Am J Mens Health 2019;13(1):1557988318816925.
52. Gabel K, Kroeger CM, Trepanowski JF, Hoddy KK, Cienfuegos S, Kalam F, Varady KA. Differential Effects of Alternate-Day Fasting Versus Daily Calorie Restriction on Insulin Resistance. Obesity (Silver Spring) 2019;27(9):1443-50.
53. Kroeger CM, Trepanowski JF, Klempel MC, Barnosky A, Bhutani S, Gabel K, Varady KA. Eating behavior traits of successful weight losers during 12 months of alternate-day fasting: An exploratory analysis of a randomized controlled trial. Nutr Health 2018;24(1):5-10.
54. Trepanowski JF, Kroeger CM, Barnosky A, Klempel M, Bhutani S, Hoddy KK, Rood J, Ravussin E, Varady KA. Effects of alternate-day fasting or daily calorie restriction on body composition, fat distribution, and circulating adipokines: Secondary analysis of a randomized controlled trial. Clin Nutr 2018;37(6 Pt A):1871-8.
55. Hoddy KK, Gibbons C, Kroeger CM, Trepanowski JF, Barnosky A, Bhutani S, Gabel K, Finlayson G, Varady KA. Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting. Clin Nutr 2016;35(6):1380-5.
56. Varady KA, Hoddy KK, Kroeger CM, Trepanowski JF, Klempel MC, Barnosky A, Bhutani S. Determinants of weight loss success with alternate day fasting. Obes Res Clin Pract 2016;10(4):476-80.
57. Varady KA, Dam VT, Klempel MC, Horne M, Cruz R, Kroeger CM, Santosa S. Effects of weight loss via high fat vs. low fat alternate day fasting diets on free fatty acid profiles. Sci Rep 2015;5:7561.
58. Hoddy KK, Kroeger CM, Trepanowski JF, Barnosky A, Bhutani S, Varady KA. Meal timing during alternate day fasting: Impact on body weight and cardiovascular disease risk in obese adults. Obesity (Silver Spring) 2014;22(12):2524-31.

Year 2020, Volume: 13 Issue: 2, 249 - 271, 26.08.2020

Özge Mengi Çelik Eda Köksal

Abstract

Intermittent fasting practices, which have recently become a popular topic, are an alternative energy restriction method. 'Time-restricted feeding', 'alternate day fasting', 'the 5: 2 diet' and 'Ramadan fasting' are the most frequently used fasting protocols in the literature. Studies have been emphasized that these practices can be effective in obesity, insulin resistance, dyslipidemia, hypertension, inflammation, diabetes, cardiovascular diseases, cancer, and neurodegenerative diseases. Today, health recommendations for intermittent fasting practices are mostly based on results from animal studies. Data from human studies support that these practices may have positive effects on body composition, blood lipids, glucose and insulin levels, inflammatory cytokines, hunger-satiety hormones and blood pressure. However, individuals with chronic disease, pregnant and lactating women, young children and elderly individuals who are at high risk of nutrition in the society are at risk for the side effects of fasting practices and should avoid fasting. There is need for research evaluating the long-term health outcomes to clarify the effects of intermittent fasting practices in healthy populations and individuals with chronic disease. In this review, the effect of intermittent fasting practices on body composition and biochemical parameters was investigated by human studies.

Keywords

Intermittent fasting, body composition, biochemical parameters

References

1. World Health Organization. Obesity and overweight. Erişim yeri: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight, Erişim Tarihi: 24.03.2020.
2. Templeman I, Gonzalez JT. The role of intermittent fasting and meal timing in weight management and metabolic health. Proc Nutr Soc 2019:1-12.
3. Tinsley GM, La Bounty PM. Effects of intermittent fasting on body composition and clinical health markers in humans. Nutr Rev 2015;73(10):661-74.
4. Patterson RE, Sears DD. Metabolic Effects of Intermittent Fasting. Annu Rev Nutr 2017;37:371-93.
5. Rothschild J, Hoddy KK, Jambazian P, Varady KA. Time-restricted feeding and risk of metabolic disease: a review of human and animal studies. Nutr Rev 2014;72(5):308-18.
6. Varady KA, Hellerstein MK. Do calorie restriction or alternate-day fasting regimens modulate adipose tissue physiology in a way that reduces chronic disease risk? Nutr Rev 2008;66(6):333-42.
7. Harvie MN, Pegington M, Mattson MP, Frystyk J, Dillon B, Evans G, Cuzick J, Jebb SA, Martin B, Cutler RG, Son TG, Maudsley S, Carlson OD, Egan JM, Flyvbjerg A, Howell A. The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women. Int J Obes (Lond) 2011;35(5):714-27.
8. Nugraha B, Ghashang SK, Hamdan I, Gutenbrunner C. Effect of Ramadan fasting on fatigue, mood, sleepiness, and health-related quality of life of healthy young men in summer time in Germany: A prospective controlled study. Appetite 2017;111:38-45.
9. Horne BD, Muhlestein JB, Anderson JL. Health effects of intermittent fasting: hormesis or harm? A systematic review. Am J Clin Nutr 2015;102(2):464-70.
10. Harris L, Hamilton S, Azevedo LB, Olajide J, De Brun C, Waller G. Intermittent fasting interventions for treatment of overweight and obesity in adults: a systematic review and meta-analysis. JBI Database System Rev Implement Rep 2018;16(2):507-47.
11. Malinowski B, Zalewska K, Wesierska A, Sokolowska MM, Socha M, Liczner G. Intermittent Fasting in Cardiovascular Disorders-An Overview. Nutrients 2019;11(3).
12. Paoli A, Tinsley G. The Influence of Meal Frequency and Timing on Health in Humans: The Role of Fasting. Nutrients 2019;11(4).
13. de Cabo R, Mattson MP. Effects of Intermittent Fasting on Health, Aging, and Disease. N Engl J Med 2019;381(26):2541-51.
14. Moro T, Tinsley G. Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males. J Transl Med 2016;14(1):290.
15. Carter S, Clifton PM, Keogh JB. The effects of intermittent compared to continuous energy restriction on glycaemic control in type 2 diabetes; a pragmatic pilot trial. Diabetes Res Clin Pract 2016;122:106-12.
16. Conley M, Le Fevre L, Haywood C, Proietto J. Is two days of intermittent energy restriction per week a feasible weight loss approach in obese males? A randomised pilot study. Nutr Diet 2018;75(1):65-72.
17. Sundfor TM, Svendsen M, Tonstad S. Effect of intermittent versus continuous energy restriction on weight loss, maintenance and cardiometabolic risk: A randomized 1-year trial. Nutr Metab Cardiovasc Dis 2018;28(7):698-706.
18. Khazneh E, Qaddumi J, Hamdan Z, Qudaimat F, Sbitany A, Jebrin K, Sawalmeh O, Abuiram Y, Shraim M. The effects of Ramadan fasting on clinical and biochemical markers among hemodialysis patients: A prospective cohort study. PloS one 2019;14(6).
19. Einollahi B, Shahyad S, Lotfiazar A. Re: Clinical and Biochemical Parameters of Hemodialysis Patients before and during the Islamic Ramadan Month. Iran J Kidney Dis 2017;11(2):168.
20. Imtiaz S, Salman B, Dhrolia MF, Nasir K, Abbas HN, Ahmad A. Clinical and Biochemical Parameters of Hemodialysis Patients Before and During Islamic Month of Ramadan. Iran J Kidney Dis 2017;11(2):168. 2016;10(2):75-8.
21. Alshamsi S, Binsaleh F, Hejaili F, Karkar A, Moussa D, Raza H, et Parbat P, Al Suwida A, Alobaili S, AlSehli R, Al Sayyari A. Changes in biochemical, hemodynamic, and dialysis adherence parameters in hemodialysis patients during Ramadan. Hemodial Int 2016;20(2):270-6.
22. Yeoh EC, Zainudin SB, Loh WN, Chua CL, Fun S, Subramaniam T, Sum CF, Lim SC. Fasting during Ramadan and Associated Changes in Glycaemia, Caloric Intake and Body Composition with Gender Differences in Singapore. Ann Acad Med Singapore 2015;44(6):202-6.
23. Mattson MP, Moehl K, Ghena N, Schmaedick M, Cheng A. Intermittent metabolic switching, neuroplasticity and brain health. Nat Rev Neurosci 2018;19(2):63.
24. Swindell WR. Dietary restriction in rats and mice: a meta-analysis and review of the evidence for genotype-dependent effects on lifespan. Ageing Res Rev 2012;11(2):254-70.
25. Nencioni A, Caffa I, Cortellino S, Longo VD. Fasting and cancer: molecular mechanisms and clinical application. Nat Rev Cancer 2018;18(11):707.
26. Corley BT, Carroll RW, Hall RM, Weatherall M, Parry-Strong A, Krebs JD. Intermittent fasting in Type 2 diabetes mellitus and the risk of hypoglycaemia: a randomized controlled trial. Diabet Med 2018;35(5):588-94.
27. Carter S, Clifton PM, Keogh JB. Effect of Intermittent Compared With Continuous Energy Restricted Diet on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Noninferiority Trial. JAMA Netw Open 2018;1(3):e180756.
28. Parvaresh A, Razavi R, Abbasi B, Yaghoobloo K, Hassanzadeh A, Mohammadifard N. Modified alternate-day fasting vs. calorie restriction in the treatment of patients with metabolic syndrome: A randomized clinical trial. Complement Ther Med 2019;47:102187.
29. O’Flanagan CH, Smith LA, McDonell SB, Hursting SD. When less may be more: calorie restriction and response to cancer therapy. BMC Med 2017;15(1):106.
30. Rohm M, Zeigerer A, Machado J, Herzig S. Energy metabolism in cachexia. EMBO Rep 2019;20(4).
31. Wlodarek D. Role of Ketogenic Diets in Neurodegenerative Diseases (Alzheimer's Disease and Parkinson's Disease). Nutrients 2019;11(1).
32. Grajower MM, Horne BD. Clinical Management of Intermittent Fasting in Patients with Diabetes Mellitus. Nutrients 2019;11(4).
33. Gabel K, Hoddy KK, Haggerty N, Song J, Kroeger CM, Trepanowski JF, Panda S, Varady KA. Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: A pilot study. Nutr Healthy Aging 2018;4(4):345-53.
34. LeCheminant JD, Christenson E, Bailey BW, Tucker LA. Restricting night-time eating reduces daily energy intake in healthy young men: a short-term cross-over study. Br J Nutr 2013;110(11):2108-13.
35. Catenacci VA, Pan Z, Ostendorf D, Brannon S, Gozansky WS, Mattson MP, Martin B, MacLean PS, Melanson EL, Troy Donahoo W. A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity. Obesity (Silver Spring) 2016;24(9):1874-83.
36. Unalacak M, Kara IH, Baltaci D, Erdem O, Bucaktepe PG. Effects of Ramadan fasting on biochemical and hematological parameters and cytokines in healthy and obese individuals. Metab Syndr Relat Disord 2011;9(2):157-61.
37. Santos HO, Macedo RCO. Impact of intermittent fasting on the lipid profile: Assessment associated with diet and weight loss. Clin Nutr ESPEN 2018;24:14-21.
38. Longo VD, Mattson MP. Fasting: molecular mechanisms and clinical applications. Cell Metab 2014;19(2):181-92.
39. Golbidi S, Daiber A, Korac B, Li H, Essop MF, Laher I. Health Benefits of Fasting and Caloric Restriction. Curr Diab Rep 2017;17(12):123.
40. Sutton EF, Beyl R, Early KS, Cefalu WT, Ravussin E, Peterson CM. Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. Cell Metab 2018;27(6):1212-21.e3.
41. Tinsley GM, Forsse JS, Butler NK, Paoli A, Bane AA, La Bounty PM, Morgan GB, Grandjean PW. Time-restricted feeding in young men performing resistance training: A randomized controlled trial. Eur J Sport Sci 2017;17(2):200-7.
42. Kesztyus D, Cermak P, Gulich M, Kesztyus T. Adherence to Time-Restricted Feeding and Impact on Abdominal Obesity in Primary Care Patients: Results of a Pilot Study in a Pre-Post Design. Nutrients 2019;11(12).
43. Varady KA, Hellerstein MK. Alternate-day fasting and chronic disease prevention: a review of human and animal trials. Am J Clin Nutr 2007;86(1):7-13.
44. M S, Ah SA, Sr S, Km B. Effect of Ramadan Fasting on Body Weight, (BP) and Biochemical Parameters in Middle Aged Hypertensive Subjects: An Observational Trial. J Clin Diagn Res 2014;8(3):16-8.
45. Nachvak SM, Pasdar Y, Pirsaheb S, Darbandi M, Niazi P, Mostafai R, Speakman JR. Effects of Ramadan on food intake, glucose homeostasis, lipid profiles and body composition composition. Eur J Clin Nutr 2019;73(4):594-600.
46. Lopez-Bueno M, Gonzalez-Jimenez E, Navarro-Prado S, Montero-Alonso MA, Schmidt-RioValle J. Influence of age and religious fasting on the body composition of Muslim women living in a westernized context. Nutr Hosp 2014;31(3):1067-73.
47. Kiyani MM, Memon AR, Amjad MI, Ameer MR, Sadiq M, Mahmood T. Study of Human Biochemical Parameters During and After Ramadan. J Relig Health 2017;56(1):55-62.
48. Harder-Lauridsen NM, Rosenberg A, Benatti FB, Damm JA, Thomsen C, Mortensen EL, Pedersen BK, Krogh-Madsen R. Ramadan model of intermittent fasting for 28 d had no major effect on body composition, glucose metabolism, or cognitive functions in healthy lean men. Nutrition 2017;37:92-103.
49. Rohin MA, Rozano N, Abd Hadi N, Mat Nor MN, Abdullah S, Dandinasivara Venkateshaiah M. Anthropometry and body composition status during Ramadan among higher institution learning centre staffs with different body weight status. ScientificWorldJournal 2013;2013:308041.
50. Ongsara S, Boonpol S, Prompalad N, Jeenduang N. The Effect of Ramadan Fasting on Biochemical Parameters in Healthy Thai Subjects. J Clin Diagn Res 2017;11(9):Bc14-bc8.
51. Al-Barha NS, Aljaloud KS. The Effect of Ramadan Fasting on Body Composition and Metabolic Syndrome in Apparently Healthy Men. Am J Mens Health 2019;13(1):1557988318816925.
52. Gabel K, Kroeger CM, Trepanowski JF, Hoddy KK, Cienfuegos S, Kalam F, Varady KA. Differential Effects of Alternate-Day Fasting Versus Daily Calorie Restriction on Insulin Resistance. Obesity (Silver Spring) 2019;27(9):1443-50.
53. Kroeger CM, Trepanowski JF, Klempel MC, Barnosky A, Bhutani S, Gabel K, Varady KA. Eating behavior traits of successful weight losers during 12 months of alternate-day fasting: An exploratory analysis of a randomized controlled trial. Nutr Health 2018;24(1):5-10.
54. Trepanowski JF, Kroeger CM, Barnosky A, Klempel M, Bhutani S, Hoddy KK, Rood J, Ravussin E, Varady KA. Effects of alternate-day fasting or daily calorie restriction on body composition, fat distribution, and circulating adipokines: Secondary analysis of a randomized controlled trial. Clin Nutr 2018;37(6 Pt A):1871-8.
55. Hoddy KK, Gibbons C, Kroeger CM, Trepanowski JF, Barnosky A, Bhutani S, Gabel K, Finlayson G, Varady KA. Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting. Clin Nutr 2016;35(6):1380-5.
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There are 58 citations in total.

Details

Primary Language	Turkish
Subjects	Health Care Administration
Journal Section	Articles
Authors	Özge Mengi Çelik 0000-0002-0298-9591 Eda Köksal 0000-0002-7930-9910
Publication Date	August 26, 2020
Submission Date	March 24, 2020
Acceptance Date	June 30, 2020
Published in Issue	Year 2020 Volume: 13 Issue: 2

Cite

APA	Mengi Çelik, Ö., & Köksal, E. (2020). Aralıklı açlık uygulamalarının vücut bileşimi ve biyokimyasal parametreler üzerine etkisi: Bir literatür derlemesi. Mersin Üniversitesi Sağlık Bilimleri Dergisi, 13(2), 249-271. https://doi.org/10.26559/mersinsbd.708821
AMA	Mengi Çelik Ö, Köksal E. Aralıklı açlık uygulamalarının vücut bileşimi ve biyokimyasal parametreler üzerine etkisi: Bir literatür derlemesi. Mersin Univ Saglık Bilim derg. August 2020;13(2):249-271. doi:10.26559/mersinsbd.708821
Chicago	Mengi Çelik, Özge, and Eda Köksal. “Aralıklı açlık uygulamalarının vücut bileşimi Ve Biyokimyasal Parametreler üzerine Etkisi: Bir literatür Derlemesi”. Mersin Üniversitesi Sağlık Bilimleri Dergisi 13, no. 2 (August 2020): 249-71. https://doi.org/10.26559/mersinsbd.708821.
EndNote	Mengi Çelik Ö, Köksal E (August 1, 2020) Aralıklı açlık uygulamalarının vücut bileşimi ve biyokimyasal parametreler üzerine etkisi: Bir literatür derlemesi. Mersin Üniversitesi Sağlık Bilimleri Dergisi 13 2 249–271.
IEEE	Ö. Mengi Çelik and E. Köksal, “Aralıklı açlık uygulamalarının vücut bileşimi ve biyokimyasal parametreler üzerine etkisi: Bir literatür derlemesi”, Mersin Univ Saglık Bilim derg, vol. 13, no. 2, pp. 249–271, 2020, doi: 10.26559/mersinsbd.708821.
ISNAD	Mengi Çelik, Özge - Köksal, Eda. “Aralıklı açlık uygulamalarının vücut bileşimi Ve Biyokimyasal Parametreler üzerine Etkisi: Bir literatür Derlemesi”. Mersin Üniversitesi Sağlık Bilimleri Dergisi 13/2 (August 2020), 249-271. https://doi.org/10.26559/mersinsbd.708821.
JAMA	Mengi Çelik Ö, Köksal E. Aralıklı açlık uygulamalarının vücut bileşimi ve biyokimyasal parametreler üzerine etkisi: Bir literatür derlemesi. Mersin Univ Saglık Bilim derg. 2020;13:249–271.
MLA	Mengi Çelik, Özge and Eda Köksal. “Aralıklı açlık uygulamalarının vücut bileşimi Ve Biyokimyasal Parametreler üzerine Etkisi: Bir literatür Derlemesi”. Mersin Üniversitesi Sağlık Bilimleri Dergisi, vol. 13, no. 2, 2020, pp. 249-71, doi:10.26559/mersinsbd.708821.
Vancouver	Mengi Çelik Ö, Köksal E. Aralıklı açlık uygulamalarının vücut bileşimi ve biyokimyasal parametreler üzerine etkisi: Bir literatür derlemesi. Mersin Univ Saglık Bilim derg. 2020;13(2):249-71.

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MEU Journal of Health Sciences Assoc was began to the publishing process in 2008 under the supervision of Assoc. Prof. Gönül Aslan, Editor-in-Chief, and affiliated to Mersin University Institute of Health Sciences. In March 2015, Prof. Dr. Caferi Tayyar Şaşmaz undertook the Editor-in Chief position and since then he has been in charge.

Publishing in three issues per year (April - August - December), it is a multisectoral refereed scientific journal. In addition to research articles, scientific articles such as reviews, case reports and letters to the editor are published in the journal. Our journal, which has been published via e-mail since its inception, has been published both online and in print. Following the Participation Agreement signed with TÜBİTAK-ULAKBİM Dergi Park in April 2015, it has started to accept and evaluate online publications.

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