Çocuklarda COVİD-19 ile ilişkili Çoklu Sistemik İnflamatuvar Sendrom

Mehtap Akça; Berfin Özgökçe Özmen; Nihan Özel Erçel; Necdet Kuyucu

Research Article

Çocuklarda COVİD-19 ile ilişkili Çoklu Sistemik İnflamatuvar Sendrom

Year 2022, Volume: 15 Issue: (Özel Sayı-1) 21. Mersin Pediatri Günleri Bildiri Kitabı, 170 - 183, 30.06.2022

Mehtap Akça Berfin Özgökçe Özmen Nihan Özel Erçel Necdet Kuyucu

Abstract

Amaç: SARS-CoV-2 ile ilişkili çoklu sistemik inflamatuvar sendrom tehlikeli ve ölümcül olarak seyredebilen yeni bir pediatrik hastalıktır. Kliniğimizde COVID-19 ile ilişkili Çoklu Sistemik İnflamatuvar Sendrom (MIS-C) tanısı alan çocukların klinik özelliklerini ve kısa dönem sonuçlarını tanımlamayı amaçladık. Yöntem: Hastanemiz Çocuk Enfeksiyon Hastalıkları Covid polikliniği ve Çocuk Acil polikliniğine 01.10.2020 ile 29.12. 2021 tarihleri arasında başvuran 1ay-18 yaş aralığında yer alan MIS-C tanısı alan 30 hasta dosyaları ve tıbbi kayıtları geriye dönük olarak tarandı. Hastaların demografik bilgileri, klinik bulguları, laboratuvar değerleri, Ekokardiyografi (EKO) bulguları ve tedavi şekilleri kaydedildi. Bulgular: Hastaların %60’ı (n= 18) erkeklerden oluşmaktadır. Yaş ortalamaları 8.07±4.38 yıl idi (1-16 yıl). Hastaların %83.3’ü (n=25) Çocuk Enfeksiyon Hastalıkları Servisi’ne, %16.7'si (n=5) Çocuk Yoğun Bakım Ünitesi’ne yatırıldı. Hastaların %66.6 (n=20)‘sında aile içi temas, %3.3’ünde (n=1) aile dışı temas saptanırken, %30’unda (n=9) herhangi bir temas öyküsü alınmadı. Hastaların %96.6’sında (n=29) COVID-19 antikor pozitif olup yalnızca 1 hastada COVID-19 Rt-PCR (gerçek zamanlı polimeraz zincir reaksiyonu) pozitif saptandı. Başvuru anında hastaların %3.3’ünde (n=1) ateş ve öksürük, %6.6’sında (n=2) ateş, öksürük ve nefes darlığı, %63.3’ünde (n=19) ateş, öksürükle beraber döküntü, konjonktivit, lenfadenopati varken ayrıca %13.3’ünde (n=4) solunum yetmezliği, %13.3’ünde (n=4) de karın ağrısı eşlik ediyordu.
Sonuç: COVID-19 ilişkili MIS-C’nin sağlıklı çocuklarda ve ergenlerde ciddi ve hayatı tehdit eden hastalığa yol açabileceği literatürde gösterilmiştir. COVID-19’un klinik bulgularının anlaşılmaya çalışıldığı salgın sürecinde MIS-C’nin geniş bir klinik spektrum gösterdiği ve farklı klinik sistem patolojileriyle hastaların başvuracağı ayırıcı tanıda akılda tutulmalıdır

Keywords

COVID-19, MIS-C, çocuk

References

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9. Dorjee K, Kim H, Bonomo E, Dolma R. Prevalence and predictors of death and severe disease in patients hospitalized due to COVID-19: A comprehensive systematic review and meta-analysis of 77 studies and 38,000 patients. PLoS One. 2020;15(12):e0243191. Published 2020 Dec 7. doi:10.1371/journal.pone.0243191
10. Chen J, Jiang Q, Xia X, et al. Individual variation of the SARS-CoV-2 receptor ACE2 gene expression and regulation. Aging Cell. 2020;19(7):e13168. doi:10.1111/acel.13168
11. Felsenstein S, Hedrich CM. COVID-19 in children and young people. Lancet Rheumatol. 2020;2(9):e514-e516. doi:10.1016/S2665-9913(20)30212-5
12. Lee PI, Hu YL, Chen PY, Huang YC, Hsueh PR. Are children less susceptible to COVID-19?. J Microbiol Immunol Infect. 2020;53(3):371-372. doi:10.1016/j.jmii.2020.02.011
13. Lee PI, Hu YL, Chen PY,Huang YC, Hsueh PR. Are children less susceptible to COVID-19? Microbiol Immunol Infect. 2020;53(3):371-372. doi:10.1016/j.jmii.2020.02.011
14. Fang F, Luo XP. [Facing the pandemic of 2019 novel coronavirus infections: the pediatric perspectives]. Zhonghua Er Ke Za Zhi. 2020 Feb 2;58(2):81-85. Chinese. doi: 10.3760/cma.j.issn.0578-1310.2020.02.001.
15. Bunyavanich S, Do A, Vicencio A. Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults. JAMA. 2020;323(23):2427-2429. doi:10.1001/jama.2020.8707
16. National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases. CDC COVID-19 Science Briefs [Internet]. Atlanta (GA): Centers for Disease Control and Prevention (US); 2020-. Science Brief: Transmission of SARS-CoV-2 in K-12 Schools and Early Care and Education Programs – Updated. [Updated 2021 Dec 17]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK570438/
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19. Benn CS, Netea MG, Selin LK, Aaby P. A small jab - a big effect: nonspecific immunomodulation by vaccines. Trends Immunol. 2013;34(9):431-439. doi:10.1016/j.it.2013.04.004
20. Jin XM, Xu X. [The Society of Pediatrics, Chinese Medical Association-an intensive training programme for developmental and behavioral pediatrics]. Zhonghua Er Ke Za Zhi. 2013 Nov;51(11):879-80. Chinese.
21. Karbuz A, Akkoc G, Bedir Demirdag T, et al. Epidemiological, Clinical, and Laboratory Features of Children With COVID-19 in Turkey. Front Pediatr. 2021;9:631547. Published 2021 May 7. doi:10.3389/fped.2021.631547
22. Lu X, Zhang L, Du H, et al. SARS-CoV-2 Infection in Children. N Engl J Med. 2020;382(17):1663-1665. doi:10.1056/NEJMc2005073
23. Dong Y, Mo X, Hu Y, et al. Epidemiology of COVID-19 Among Children in China. Pediatrics. 2020;145(6): e20200702. doi:10.1542/peds.2020-0702
24. Ding Y, Yan H, Guo W. Clinical Characteristics of Children With COVID-19: A Meta-Analysis. Front Pediatr. 2020;8:431. Published 2020 Jul 3. doi:10.3389/fped.2020.00431
25. Hoang A, Chorath K, Moreira A, et al. COVID-19 in 7780 pediatric patients: A systematic review. E Clinical Medicine. 2020;24:100433. Published 2020 Jun 26. doi:10.1016/j.eclinm.2020.100433
26. Korkmaz MF, Türe E, Dorum BA, Kılıç ZB. The Epidemiological and Clinical Characteristics of 81 Children with COVID-19 in a Pandemic Hospital in Turkey: an Observational Cohort Study. J Korean Med Sci. 2020;35(25):e236. Published 2020 Jun 29. doi:10.3346/jkms.2020.35.e236
27. Cura Yayla BC, Özsürekçi Y, Aykaç K, et al. Characteristics and Management of Children with COVID-19 in Turkey. Balkan Med J. 2020;37(6):341-347. doi:10.4274/ balkanmedj.galenos.2020.2020.7.52
28. Mustafa NM, A Selim L. Characterisation of COVID-19 Pandemic in Paediatric Age Group: A Systematic Review and Meta-Analysis. J Clin Virol. 2020;128:104395. doi:10.1016/j.jcv.2020.104395

Year 2022, Volume: 15 Issue: (Özel Sayı-1) 21. Mersin Pediatri Günleri Bildiri Kitabı, 170 - 183, 30.06.2022

Mehtap Akça Berfin Özgökçe Özmen Nihan Özel Erçel Necdet Kuyucu

Abstract

References

1. Eurosurveillance Editorial Team. Note from the editors: World Health Organization declares novel coronavirus (2019-nCoV) sixth public health emergency of international concern. Euro Surveill. 2020;25(5):200131e. doi:10.2807/1560-7917.ES.2020.25.5.200131e
2. Ladhani SN, Amin-Chowdhury Z, Davies HG, et al. COVID-19 in children: analysis of the first pandemic peak in England. Arch Dis Child. 2020;105(12):1180-1185. doi:10.1136/archdischild-2020-320042
3. Parri N, Lenge M, Buonsenso D; Coronavirus Infection in Pediatric Emergency Departments (CONFIDENCE) Research Group. Children with Covid-19 in Pediatric Emergency Departments in Italy. N Engl J Med. 2020;383(2):187-190. doi:10.1056/NEJMc2007617
4. Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239-1242. doi:10.1001/jama.2020.2648
5. Bi Q, Wu Y, Mei S, et al. Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study [published correction appears in Lancet Infect Dis. 2020 Jul;20(7):e148]. Lancet Infect Dis. 2020;20(8):911-919. doi:10.1016/S1473-3099(20)30287-5
6. Sinha IP, Harwood R, Semple MG, et al. COVID-19 infection in children. Lancet Respir Med. 2020;8(5):446-447. doi:10.1016/S2213-2600(20)30152-1
7. Nikolopoulou GB, Maltezou HC. COVID-19 in Children: Where do we Stand?. Arch Med Res. 2022;53(1):1-8. doi:10.1016/j.arcmed.2021.07.002
8. Li H, Liu Z, Ge J. Scientific research progress of COVID-19/SARS-CoV-2 in the first five months. J Cell Mol Med. 2020;24(12):6558-6570. doi:10.1111/jcmm.15364
9. Dorjee K, Kim H, Bonomo E, Dolma R. Prevalence and predictors of death and severe disease in patients hospitalized due to COVID-19: A comprehensive systematic review and meta-analysis of 77 studies and 38,000 patients. PLoS One. 2020;15(12):e0243191. Published 2020 Dec 7. doi:10.1371/journal.pone.0243191
10. Chen J, Jiang Q, Xia X, et al. Individual variation of the SARS-CoV-2 receptor ACE2 gene expression and regulation. Aging Cell. 2020;19(7):e13168. doi:10.1111/acel.13168
11. Felsenstein S, Hedrich CM. COVID-19 in children and young people. Lancet Rheumatol. 2020;2(9):e514-e516. doi:10.1016/S2665-9913(20)30212-5
12. Lee PI, Hu YL, Chen PY, Huang YC, Hsueh PR. Are children less susceptible to COVID-19?. J Microbiol Immunol Infect. 2020;53(3):371-372. doi:10.1016/j.jmii.2020.02.011
13. Lee PI, Hu YL, Chen PY,Huang YC, Hsueh PR. Are children less susceptible to COVID-19? Microbiol Immunol Infect. 2020;53(3):371-372. doi:10.1016/j.jmii.2020.02.011
14. Fang F, Luo XP. [Facing the pandemic of 2019 novel coronavirus infections: the pediatric perspectives]. Zhonghua Er Ke Za Zhi. 2020 Feb 2;58(2):81-85. Chinese. doi: 10.3760/cma.j.issn.0578-1310.2020.02.001.
15. Bunyavanich S, Do A, Vicencio A. Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults. JAMA. 2020;323(23):2427-2429. doi:10.1001/jama.2020.8707
16. National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases. CDC COVID-19 Science Briefs [Internet]. Atlanta (GA): Centers for Disease Control and Prevention (US); 2020-. Science Brief: Transmission of SARS-CoV-2 in K-12 Schools and Early Care and Education Programs – Updated. [Updated 2021 Dec 17]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK570438/
17. Luca Cristiani, Enrica Mancino, Luigi Matera et all European Respiratory Journal 2020 55: 2000749; doi: 10.1183/13993003.00749-2020.
18. de Bree LCJ, Koeken VACM, Joosten LAB, et al. Non-specific effects of vaccines: Current evidence and potential implications. Semin Immunol. 2018;39:35-43. doi:10.1016/j.smim.2018.06.002
19. Benn CS, Netea MG, Selin LK, Aaby P. A small jab - a big effect: nonspecific immunomodulation by vaccines. Trends Immunol. 2013;34(9):431-439. doi:10.1016/j.it.2013.04.004
20. Jin XM, Xu X. [The Society of Pediatrics, Chinese Medical Association-an intensive training programme for developmental and behavioral pediatrics]. Zhonghua Er Ke Za Zhi. 2013 Nov;51(11):879-80. Chinese.
21. Karbuz A, Akkoc G, Bedir Demirdag T, et al. Epidemiological, Clinical, and Laboratory Features of Children With COVID-19 in Turkey. Front Pediatr. 2021;9:631547. Published 2021 May 7. doi:10.3389/fped.2021.631547
22. Lu X, Zhang L, Du H, et al. SARS-CoV-2 Infection in Children. N Engl J Med. 2020;382(17):1663-1665. doi:10.1056/NEJMc2005073
23. Dong Y, Mo X, Hu Y, et al. Epidemiology of COVID-19 Among Children in China. Pediatrics. 2020;145(6): e20200702. doi:10.1542/peds.2020-0702
24. Ding Y, Yan H, Guo W. Clinical Characteristics of Children With COVID-19: A Meta-Analysis. Front Pediatr. 2020;8:431. Published 2020 Jul 3. doi:10.3389/fped.2020.00431
25. Hoang A, Chorath K, Moreira A, et al. COVID-19 in 7780 pediatric patients: A systematic review. E Clinical Medicine. 2020;24:100433. Published 2020 Jun 26. doi:10.1016/j.eclinm.2020.100433
26. Korkmaz MF, Türe E, Dorum BA, Kılıç ZB. The Epidemiological and Clinical Characteristics of 81 Children with COVID-19 in a Pandemic Hospital in Turkey: an Observational Cohort Study. J Korean Med Sci. 2020;35(25):e236. Published 2020 Jun 29. doi:10.3346/jkms.2020.35.e236
27. Cura Yayla BC, Özsürekçi Y, Aykaç K, et al. Characteristics and Management of Children with COVID-19 in Turkey. Balkan Med J. 2020;37(6):341-347. doi:10.4274/ balkanmedj.galenos.2020.2020.7.52
28. Mustafa NM, A Selim L. Characterisation of COVID-19 Pandemic in Paediatric Age Group: A Systematic Review and Meta-Analysis. J Clin Virol. 2020;128:104395. doi:10.1016/j.jcv.2020.104395

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Details

Primary Language	Turkish
Subjects	Health Care Administration
Journal Section	Sözlü Bildiriler
Authors	Mehtap Akça This is me Berfin Özgökçe Özmen This is me Nihan Özel Erçel This is me Necdet Kuyucu This is me
Publication Date	June 30, 2022
Submission Date	March 8, 2022
Acceptance Date	March 10, 2022
Published in Issue	Year 2022 Volume: 15 Issue: (Özel Sayı-1) 21. Mersin Pediatri Günleri Bildiri Kitabı

Cite

APA	Akça, M., Özgökçe Özmen, B., Özel Erçel, N., Kuyucu, N. (2022). Çocuklarda COVİD-19 ile ilişkili Çoklu Sistemik İnflamatuvar Sendrom. Mersin Üniversitesi Sağlık Bilimleri Dergisi, 15((Özel Sayı-1) 21. Mersin Pediatri Günleri Bildiri Kitabı), 170-183.
AMA	Akça M, Özgökçe Özmen B, Özel Erçel N, Kuyucu N. Çocuklarda COVİD-19 ile ilişkili Çoklu Sistemik İnflamatuvar Sendrom. Mersin Univ Saglık Bilim derg. June 2022;15((Özel Sayı-1) 21. Mersin Pediatri Günleri Bildiri Kitabı):170-183.
Chicago	Akça, Mehtap, Berfin Özgökçe Özmen, Nihan Özel Erçel, and Necdet Kuyucu. “Çocuklarda COVİD-19 Ile ilişkili Çoklu Sistemik İnflamatuvar Sendrom”. Mersin Üniversitesi Sağlık Bilimleri Dergisi 15, no. (Özel Sayı-1) 21. Mersin Pediatri Günleri Bildiri Kitabı (June 2022): 170-83.
EndNote	Akça M, Özgökçe Özmen B, Özel Erçel N, Kuyucu N (June 1, 2022) Çocuklarda COVİD-19 ile ilişkili Çoklu Sistemik İnflamatuvar Sendrom. Mersin Üniversitesi Sağlık Bilimleri Dergisi 15 (Özel Sayı-1) 21. Mersin Pediatri Günleri Bildiri Kitabı 170–183.
IEEE	M. Akça, B. Özgökçe Özmen, N. Özel Erçel, and N. Kuyucu, “Çocuklarda COVİD-19 ile ilişkili Çoklu Sistemik İnflamatuvar Sendrom”, Mersin Univ Saglık Bilim derg, vol. 15, no. (Özel Sayı-1) 21. Mersin Pediatri Günleri Bildiri Kitabı, pp. 170–183, 2022.
ISNAD	Akça, Mehtap et al. “Çocuklarda COVİD-19 Ile ilişkili Çoklu Sistemik İnflamatuvar Sendrom”. Mersin Üniversitesi Sağlık Bilimleri Dergisi 15/(Özel Sayı-1) 21. Mersin Pediatri Günleri Bildiri Kitabı (June 2022), 170-183.
JAMA	Akça M, Özgökçe Özmen B, Özel Erçel N, Kuyucu N. Çocuklarda COVİD-19 ile ilişkili Çoklu Sistemik İnflamatuvar Sendrom. Mersin Univ Saglık Bilim derg. 2022;15:170–183.
MLA	Akça, Mehtap et al. “Çocuklarda COVİD-19 Ile ilişkili Çoklu Sistemik İnflamatuvar Sendrom”. Mersin Üniversitesi Sağlık Bilimleri Dergisi, vol. 15, no. (Özel Sayı-1) 21. Mersin Pediatri Günleri Bildiri Kitabı, 2022, pp. 170-83.
Vancouver	Akça M, Özgökçe Özmen B, Özel Erçel N, Kuyucu N. Çocuklarda COVİD-19 ile ilişkili Çoklu Sistemik İnflamatuvar Sendrom. Mersin Univ Saglık Bilim derg. 2022;15((Özel Sayı-1) 21. Mersin Pediatri Günleri Bildiri Kitabı):170-83.

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