Abstract
Amaç: Ciddi akut solunumsal sendrom koronavirüs tip-2 (SARS-CoV-2) asemptomatik klinik seyirden, ağır akut enfeksiyon (COVID-19) ve çocuklarda multisistem inflamatuvar sendroma (MIS-Ç) kadar giden ciddi semptomatik hastalıklara yol açabilir. Bu çalışma ile MIS-Ç tanısı almış hastalarda eşlik edebilecek kardiyak aritmi riskini hesaplamayı ve değerlendirmeyi amaçladık. Yöntem:1 Haziran 2020 – 20 Aralık 2021 tarihleri arasında, hastanemizde Mersin Üniversitesi Çocuk Kardiyoloji ve Çocuk Enfeksiyon bölümlerinde takip edilen, Covid-19 pandemisi döneminde, SARS-CoV-2 etkeni ilişkili MIS-C tanısı ile takip edilen, araştırmanın dahil edilme ve dışlanma kriterlerine uyan 29 olgunun dosyaları geriye dönük incelendi. Bu hastalar ayrıca hafif ve ağır MIS-C olarak iki gruba ayrıldılar.Sağlıklı kontrol ve hasta grupları arasındaki elektrokardiyografi (EKG) parametreleri (Tp-e intervali, Tp-e dispersiyonu ve Tp-e/QT oranı dahil olarak) birbiriyle karşılaştırıldı. Bulgular: QT intervali ve düzeltilmiş QT (QTc), TpTe intervali, TpTe dispersiyonu ve TpTe/QTc oranı hasta olan her iki MIS-C grubunda, sağlıklı kontrol grubuna göre belirgin yüksek bulunmuştur. Ağır MIS-C tanısı alan olgularda TpTe ve TpTe/QTc oranı değerleri, hafif MIS-Ç olanlara göre belirgin yüksek bulunmuştur. Özellikle ağır MIS-C tanısı olan olgularda aritmi riskinin arttığı görüldü. Sonuç: Bu sonuçlar COVID-19 ilişkili MIS-C hastalarında T dalga ve ventriküler repolarizasyon değişikliklerinin değerlendirilmesinin, aritmi riskini belirlemede önemli rol oynadığını göstermiştir.
References
- 1. Simpson JM, Newburger JW. Multisystem Inflammatory Syndrome in Children in Association With COVID-19. Circulation. 2020;142(5):437-440.doi:10.1161/CIRCULATIONAHA.120.048726.
- 2. Toubiana J, Poirault C, Corsia A, et al. Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study. BMJ. 2020;369:m2094. Published 2020 Jun 3. doi:10.1136/bmj.m2094
- 3. Ramcharan T, Nolan O, Lai CY, et al. Paediatric Inflammatory Multisystem Syndrome: Temporally Associated with SARS-CoV-2 (PIMS-TS): Cardiac Features, Management and Short-Term Outcomes at a UK Tertiary Paediatric Hospital. Pediatr Cardiol. 2020;41(7):1391-1401. doi:10.1007/s00246-020-02391-2
- 4. Feldstein LR, Rose EB, Horwitz SM, et al. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N Engl J Med. 2020;383(4):334-346. doi:10.1056/NEJMoa2021680
- 5. Regan W, O'Byrne L, Stewart K, et al. Electrocardiographic Changes in Children with Multisystem Inflammation Associated with COVID-19: Associated with Coronavirus Disease 2019. J Pediatr. 2021;234:27-32.e2. doi:10.1016/j.jpeds.2020.12.033
- 6. World Health Organization Scientif Brief: Multisystem inflammatory syndrome in children and adolescents with COVID-19. Available at: World Health Organization Scientif Brief: Multisystem inflammatory syndrome in children and adolescents with COVID-19 (Accessed on May 17, 2020).
- 7. Theocharis P, Wong J, Pushparajah K, et al. Multimodality cardiac evaluation in children and young adults with multisystem inflammation associated with COVID-19. Eur Heart J Cardiovasc Imaging. 2021;22(8):896-903. doi:10.1093/ehjci/jeaa212
- 8. Licciardi F, Pruccoli G, Denina M, et al. SARS-CoV-2-Induced Kawasaki-Like Hyperinflammatory Syndrome: A Novel COVID Phenotype in Children. Pediatrics.2020;146(2):e20201711. doi:10.1542/peds.2020-1711
- 9. Feldstein LR, Tenforde MW, Friedman KG, et al. Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. JAMA. 2021;325(11):1074-1087. doi:10.1001/jama.2021.2091
- 10. Fujino M, Hata T, Kuriki M, et al. Inflammation aggravates heterogeneity of ventricular repolarization in children with Kawasaki disease. Pediatr Cardiol. 2014;35(7):1268-1272. doi:10.1007/s00246-014-0926-2
- 11. Brisca G, Consolaro A, Caorsi R, et al. Timely Recognition and Early Multi-Step Antinflammatory Therapy May Prevent ICU Admission of Patients With MIS-C: Proposal for a Severity Score. Front Pediatr. 2021;9:783745. Published 2021 Dec 20. doi:10.3389/fped.2021.783745
- 12. and Tp-e intervals in left and right chest leads: comparison between patients with systemic and pulmonary hypertension. J Electrocardiol. 2005;38(4 Suppl):154-158. doi:10.1016/j.jelectrocard.2005.06.028.
- 13. Gupta P, Patel C, Patel H, et al. T(p-e)/QT ratio as an index of arrhythmogenesis. J Electrocardiol. 2008;41(6):567-574. doi:10.1016/j.jelectrocard.2008.07.016
- 14. Whittaker E, Bamford A, Kenny J, et al. Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2. JAMA. 2020;324(3):259-269. doi:10.1001/jama.2020.10369
- 15. Ece İ, Koçoğlu M, Kavurt AV, et al. Assessment of Cardiac Arrhythmic Risk in Children With Covid-19 Infection. Pediatr Cardiol. 2021;42(2):264-268. doi:10.1007/s00246-020-02474-0
- 16. Hui H, Zhang Y, Yang X,et al. (2020) Clinical and radiographic features of cardiac injury in patients with 2019 novel coronavirus pneumonia. Med Rxiv.doi:10.1101/2020.02.24.20027052.
- 17. Guo T, Fan Y, Chen M, et al. Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19) [published correction appears in JAMA Cardiol. 2020 Jul 1;5(7):848]. JAMA Cardiol. 2020;5(7):811-818. doi:10.1001/jamacardio.2020.1017
- 18. Haghighi Aski B, Manafi Anari A, Abolhasan Choobdar F, Zareh Mahmoudabadi R, Sakhaei M. Cardiac abnormalities due to multisystem inflammatory syndrome temporally associated with Covid-19 among children: A systematic review and meta-analysis. Int J Cardiol Heart Vasc. 2021;33:100764. doi:10.1016/j.ijcha.2021.100764
Abstract
References
- 1. Simpson JM, Newburger JW. Multisystem Inflammatory Syndrome in Children in Association With COVID-19. Circulation. 2020;142(5):437-440.doi:10.1161/CIRCULATIONAHA.120.048726.
- 2. Toubiana J, Poirault C, Corsia A, et al. Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study. BMJ. 2020;369:m2094. Published 2020 Jun 3. doi:10.1136/bmj.m2094
- 3. Ramcharan T, Nolan O, Lai CY, et al. Paediatric Inflammatory Multisystem Syndrome: Temporally Associated with SARS-CoV-2 (PIMS-TS): Cardiac Features, Management and Short-Term Outcomes at a UK Tertiary Paediatric Hospital. Pediatr Cardiol. 2020;41(7):1391-1401. doi:10.1007/s00246-020-02391-2
- 4. Feldstein LR, Rose EB, Horwitz SM, et al. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N Engl J Med. 2020;383(4):334-346. doi:10.1056/NEJMoa2021680
- 5. Regan W, O'Byrne L, Stewart K, et al. Electrocardiographic Changes in Children with Multisystem Inflammation Associated with COVID-19: Associated with Coronavirus Disease 2019. J Pediatr. 2021;234:27-32.e2. doi:10.1016/j.jpeds.2020.12.033
- 6. World Health Organization Scientif Brief: Multisystem inflammatory syndrome in children and adolescents with COVID-19. Available at: World Health Organization Scientif Brief: Multisystem inflammatory syndrome in children and adolescents with COVID-19 (Accessed on May 17, 2020).
- 7. Theocharis P, Wong J, Pushparajah K, et al. Multimodality cardiac evaluation in children and young adults with multisystem inflammation associated with COVID-19. Eur Heart J Cardiovasc Imaging. 2021;22(8):896-903. doi:10.1093/ehjci/jeaa212
- 8. Licciardi F, Pruccoli G, Denina M, et al. SARS-CoV-2-Induced Kawasaki-Like Hyperinflammatory Syndrome: A Novel COVID Phenotype in Children. Pediatrics.2020;146(2):e20201711. doi:10.1542/peds.2020-1711
- 9. Feldstein LR, Tenforde MW, Friedman KG, et al. Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. JAMA. 2021;325(11):1074-1087. doi:10.1001/jama.2021.2091
- 10. Fujino M, Hata T, Kuriki M, et al. Inflammation aggravates heterogeneity of ventricular repolarization in children with Kawasaki disease. Pediatr Cardiol. 2014;35(7):1268-1272. doi:10.1007/s00246-014-0926-2
- 11. Brisca G, Consolaro A, Caorsi R, et al. Timely Recognition and Early Multi-Step Antinflammatory Therapy May Prevent ICU Admission of Patients With MIS-C: Proposal for a Severity Score. Front Pediatr. 2021;9:783745. Published 2021 Dec 20. doi:10.3389/fped.2021.783745
- 12. and Tp-e intervals in left and right chest leads: comparison between patients with systemic and pulmonary hypertension. J Electrocardiol. 2005;38(4 Suppl):154-158. doi:10.1016/j.jelectrocard.2005.06.028.
- 13. Gupta P, Patel C, Patel H, et al. T(p-e)/QT ratio as an index of arrhythmogenesis. J Electrocardiol. 2008;41(6):567-574. doi:10.1016/j.jelectrocard.2008.07.016
- 14. Whittaker E, Bamford A, Kenny J, et al. Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2. JAMA. 2020;324(3):259-269. doi:10.1001/jama.2020.10369
- 15. Ece İ, Koçoğlu M, Kavurt AV, et al. Assessment of Cardiac Arrhythmic Risk in Children With Covid-19 Infection. Pediatr Cardiol. 2021;42(2):264-268. doi:10.1007/s00246-020-02474-0
- 16. Hui H, Zhang Y, Yang X,et al. (2020) Clinical and radiographic features of cardiac injury in patients with 2019 novel coronavirus pneumonia. Med Rxiv.doi:10.1101/2020.02.24.20027052.
- 17. Guo T, Fan Y, Chen M, et al. Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19) [published correction appears in JAMA Cardiol. 2020 Jul 1;5(7):848]. JAMA Cardiol. 2020;5(7):811-818. doi:10.1001/jamacardio.2020.1017
- 18. Haghighi Aski B, Manafi Anari A, Abolhasan Choobdar F, Zareh Mahmoudabadi R, Sakhaei M. Cardiac abnormalities due to multisystem inflammatory syndrome temporally associated with Covid-19 among children: A systematic review and meta-analysis. Int J Cardiol Heart Vasc. 2021;33:100764. doi:10.1016/j.ijcha.2021.100764
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Sözlü Bildiriler |
| Authors | |
| Publication Date | June 30, 2022 |
| Submission Date | March 2, 2022 |
| Acceptance Date | March 10, 2022 |
| Published in Issue | Year 2022 Volume: 15 Issue: (Özel Sayı-1) 21. Mersin Pediatri Günleri Bildiri Kitabı |
Cite
MEU Journal of Health Sciences Assoc was began to the publishing process in 2008 under the supervision of Assoc. Prof. Gönül Aslan, Editor-in-Chief, and affiliated to Mersin University Institute of Health Sciences. In March 2015, Prof. Dr. Caferi Tayyar Şaşmaz undertook the Editor-in Chief position and since then he has been in charge.
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