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Structure and Functions of Acetylcholinesterase and Acetylcholinesterase Inhibitory Activity of Plants

Year 2016, Volume: 6 Issue: 1, 19 - 35, 01.06.2016

Fatma Gonca Koçancı Belma Aslım

Abstract

Alzheimer's disease (AD), defined as a neurodegenerative condition, are characterized by progressive loss of memory. Cholinergic loss is one of the most important marker of the accurate diagnosis of AD. Acetylcholinesterase inhibitors (AChEi) is the most important group of drugs for AD. But none of the indentified AChEi’s were able to cure the disease. For this reason, studies on the particularly determination of agents that have preventive and therapeutic potential on the AD become an important research field. Researchers have also begun to work on the the discovery of curative and preventive effect of the substance for AD. In this review will be informed about the structure, functions of AChE and AChEi from plants.

Keywords

Acetylcholinesterase (AChE) Alzheimer's disease Acetylcholinesterase inhibitors (AChEi’s) from plants

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Asetilkolinesterazın Yapısı ve Fonksiyonları ve Bitkilerin Asetilkolinesteraz İnhibitör Etkileri

Year 2016, Volume: 6 Issue: 1, 19 - 35, 01.06.2016

Fatma Gonca Koçancı Belma Aslım

Abstract

Alzheimer Hastalığı (AH), hafızanın sürekli bir şekilde azalması ile karakterize edilen nörodejeneratif bir durumdur. AH’nin kesin tanısında en önemli belirteçlerden biri kolinerjik kayıptır. AH’ye yönelik en önemli ilaç grubu asetilkolinesteraz inhibitörleridir (AChEi). Fakat mevcut AChEi ilaçların hiçbirinde tam başarı elde edilememiştir. Bu sebeple, AH üzerinde etkili olacak koruyucu ve tedavi edici potansiyeli olan ajanların tespitene yönelik çalışmalar önem kazanmıştır. Bu derlemede AChE’nin yapısı, fonksiyonları ve AChEi bitkiler hakkında bilgi verilecektir

Keywords

Asetilkolinesteraz (AChE) Alzheimer hastalığı Biktisel asetilkolinesteraz inhibitörleri (AChEi’leri)

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There are 168 citations in total.

Details

Other ID JA82DK45TM
Journal Section Research Article
Authors

Fatma Gonca Koçancı This is me

Belma Aslım This is me

Publication Date June 1, 2016
Submission Date June 1, 2016
Published in Issue Year 2016 Volume: 6 Issue: 1

Cite

APA Koçancı, F. G., & Aslım, B. (2016). Asetilkolinesterazın Yapısı ve Fonksiyonları ve Bitkilerin Asetilkolinesteraz İnhibitör Etkileri. Manas Journal of Agriculture Veterinary and Life Sciences, 6(1), 19-35.