Mean Platelet Volume as a New Inflammatory Marker in Acute Pancreatitis and Its Relation to C-Reactive Protein and Ranson’s Score on Admission

Year 2023, , 9 - 13, 28.04.2023

Baris Karagün , Tayyibe Saler

https://doi.org/10.29058/mjwbs.1228491

Abstract

Aim: The study’s aim is to evaluate mean platelet volume (MPV) as a marker of inflammation in patients
with acute pancreatitis (AP) and to analyse the relationships among MPV, CRP (C-reactive protein) and
Ranson’s score.
Material and Methods: In this study, 119 patients with AP (mean age 53.8 ± 18.0 years) and 88 healthy
control group (mean age 53.1 ± 6.8 years) were enrolled. Among the patients with AP, 75 were classified
as having biliary AP, and 44 were classified as having nonbiliary AP. All patients’ demographic data,
clinical and laboratory findings and Ranson’s scores were examined from the hospital’s database.
Results: MPV was significantly lower among patients with AP than among the control group (p = 0.001).
CRP was significantly higher among patients with AP than among the control group (p< 0.001). The
difference in MPV between the biliary and nonbiliary AP group was statistically not significant. When
we compared MPV based on patients’ lengths of hospital stay, there was no significant difference. In
correlation analysis, there was no correlation among CRP, Ranson’s score and serum MPV levels.
Conclusion: We observed that MPV levels in the AP group were lower than healthy controls. Thus, like
other inflammation markers, MPV might be a useful marker for AP diagnosis.

Keywords

Acute pancreatitis, Mean platelet volume, Inflammation

Akut Pankreatitte Yeni Bir İnflamatuar Belirteç Olarak Ortalama Trombosit Hacmi ve C-Reaktif Protein ile Başvuru Anındaki Ranson Skoru ile İlişkisi

Abstract

Amaç: Bu çalışmada akut pankreatitli (AP) hastalarda inflamasyon belirteci olarak ortalama trombosit
hacmini (MPV) değerlendirmek ve MPV, CRP (C-reactive protein) ile Ranson skoru arasındaki ilişkiyi
inceleme amaçlandı.
Gereç ve Yöntemler: Bu çalışmaya AP’li 119 hasta (ortalama yaş 53.8 ± 18.0 yıl) ve 88 sağlıklı kontrol
grubu (ortalama yaş 53.1 ± 6.8 yıl) alındı. AP’li hastalardan 75’i biliyer AP, 44’ü biliyer olmayan AP olarak
sınıflandırıldı. Tüm hastaların demografik verileri, klinik ve laboratuvar bulguları ve Ranson skorları
hastanenin veri tabanından incelendi.
Bulgular: MPV, AP’li hastalarda kontrol grubuna göre anlamlı olarak daha düşüktü (p = 0.001). AP’li
hastalarda CRP, kontrol grubuna göre anlamlı olarak daha yüksekti (p < 0.001). Biliyer ve biliyer
olmayan AP grup arasındaki MPV farkı istatistiksel olarak anlamlı bulunmadı. Hastaların hastanede
kalış sürelerine göre MPV değerlerini karşılaştırdığımızda anlamlı bir fark yoktu. Korelasyon analizinde
CRP, Ranson skoru ve serum MPV seviyeleri arasında korelasyon yoktu.
Sonuç: AP grubunda MPV düzeylerinin sağlıklı kontrollere göre daha düşük olduğunu gözlemledik. Bu
nedenle, diğer inflamasyon belirteçleri gibi MPV de AP tanısı için yararlı bir belirteç olabilir

Keywords

Akut pankreatit, Ortalama trombosit hacmi, inflamasyon

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