Hidradenitis Suppurativalı Hastalarda İnflamatuar Belirteçlerin Değerlerdirilmesi: Tek Merkezli Vaka-Kontrol Çalışması

Year 2023, , 128 - 136, 31.08.2023

Özge Kaya , Havva Yasemin Çinpolat

https://doi.org/10.29058/mjwbs.1278387

Abstract

Amaç: Hidradenitis suppurativa (HS), kronik inflamatuar bir deri hastalığıdır. Bu çalışmada hidradenitis
suppurativada yeni inflamatuar belirteçlerden olan monosit:HDL oranı (monosit:HDL ratio=MHR),
nötrofil:lenfosit oranı (nötrofil:lenfosit ratio=NLR), monosit:lenfosit oranının (monosit:lenfosit ratio=MLR)
değerlendirilmesi amaçlanmaktadır.
Gereç ve Yöntemler: Ocak 2012- Şubat 2023 tarihleri arasında HS tanısıyla takip edilen ve yaş-cinsiyet
açısından eşleşmiş sağlıklı kontrol grubu sosyodemografik bulgular (yaş, cinsiyet) ve laboratuvar
bulguları [yüksek yoğunluklu lipoprotein (high density lipoprotein=HDL), nötrofil sayısı, monosit sayısı,
eritrosit sedimantasyon hızı (ESH), C-reaktif protein (CRP), MHR, NLR, MLR] açısından retrospektif
olarak değerlendirildi. Elde edilen veriler hasta ve kontrol grubu arasında, ayrıca hasta grubunda
hastalık şiddeti açısından (Hurley evre 1, 2 ve 3) ve metabolik sendrom varlığına göre karşılaştırıldı.
Ayrıca hasta grubunda inflamatuar belirteçlerle korele olan bulgular değerlendirildi.
Bulgular: Çalışmaya 53 HS hastası (kadın:erkek oranı=0,6:1, yaş ort=33.32±11.37 ) ve 50 sağlıklı
kontrol (kadın:erkek oranı=0,47:1, yaş ort=36.74±11.95) dahil edildi. Hasta grubunda ortalama HDL
değeri istatistiksel olarak daha düşük saptanırken; ESH, nötrofil ve monosit sayıları, MHR ve NLR değerleri
daha yüksekti (p<0.05). Hastalar Hurley evrelemesi açısından karşılaştırıldığında; CRP, ESH
nötrofil ve monosit sayıları, MHR, NLR ve MLR değerleri evre ilerledikçe artmaktaydı, ancak bu artış
sadece ESH’nda istatistiksel olarak anlamlıydı (p=0.022). Anatomik lokalizasyon tutulum sayısı; nötrofil
sayısı, monosit sayısı, ESH, MHR, NLR, MLR ve Hurley evresiyle pozitif koreleydi. Hastalık süresi ise
MHR ile korelasyon göstermekteydi. Hastaların 11’inde (%20,8) metabolik sendrom mevcuttu. Metabolik
sendromu olan hastalarda MLR değeri daha düşük saptanırken, diğer parametrelerde istatistiksel
olarak anlamlı fark saptanmadı.
Sonuç: HS’te MHR, NLR ve MLR gibi maliyeti düşük ve kullanımı kolay olan yeni inflamatuar belirteçler
inflamatuar yükü yansıtması açısından günlük pratikte kullanılabilecek parametrelerdir.

Keywords

Hidradenitis suppurativa, inflamasyon, metabolik sendrom, monosit:HDL oranı, monosit:lenfosit oranı, nötrofil:lenfosit oranı

Thanks

Hasta verilerini toplama konusunda yardımlarından dolayı Doktor Öğretim üyesi Zeynep KESKİNKAYA ve Doktor Öğretim Üyesi Selda Işık MERMUTLU’ya; istatistiksel analizde yardımlarından dolayı Prof. Dr.Hakkı KAYA’ya teşekkürlerimi sunarım.

Evaluation of Inflammatory Markers in Patients with Hidraadenitis Suppurativa: A Single Center Case-Control Study

Abstract

Aim: In this study, it is aimed to evaluate monocyte: HDL ratio (MHR), neutrophil: lymphocyte ratio
(NLR), monocyte: lymphocyte ratio (MLR), which are new inflammatory markers, in HS.
Material and Methods: Patients followed up with the diagnosis of HS between January 2012 and
February 2023 and age-sex-matched healthy control group will be evaluated retrospectively in terms
of sociodemographic findings (age, gender), and laboratory findings [high-density lipoprotein (HDL),neutrophil count, monocyte count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), MHR, NLR, MLR]. The obtained data
will be compared between the patient and control group. In addition, patients will be compared in terms of Hurley stage and the presence of
metabolic syndrome.
Results: 53 HS patients (female: male ratio=0.6:1, age mean=33.32±11.37) and 50 healthy controls (female: male ratio=0.47:1, age
mean=36.74±11.95) were included in the study. While the mean HDL value was statistically lower in the patient group; ESR, neutrophil and
monocyte counts, MHR, and NLR values were higher (p<0.05). When the patients were compared in terms of Hurley staging; neutrophil
count, CRP, ESR, MHR, NLR ve MLR values, increased as the stage progressed, but this increase was statistically significant only at ESR
(p=0.022). The number of anatomical localization involvement was positively correlated with the neutrophil count, monocyte count, ESR,
MHR, NLR, MLR, and Hurley stage. Disease duration was correlated with MHR. Metabolic syndrome was present in 11 (20.8 %) patients.
While the MLR value was found to be lower in patients with metabolic syndrome, no statistical difference was found in other parameters.
Conclusion: New inflammatory parameters such as MHR, NLR, and MLR can be used in daily practice in terms of reflecting the inflammatory
burden in HS patients.

Keywords

Hidradenitis suppurative, inflammation, metabolic syndrome, monocyte: HDL ratio, monocyte: lymphocyte ratio, neutrophil: lymphocyte ratio

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