Polikistik over sendromunda demodex enfestasyonu ile klinik parametreler arasındaki ilişki: Prospektif gözlemsel çalışma

Abstract

Amaç: Polikistik over sendromu (PKOS), ovulatuvar disfonksiyon, hiperandrojenizm ve polikistik over morfolojisi ile karakterize, sıklıkla metabolik bozukluklarla birlikte görülen yaygın bir endokrin hastalıktır. PKOS'ta akne ve sebore gibi cilt belirtileri sık görülür ve cildin yağ bakımından zengin bölgelerinde yaşayan Demodex türleri çeşitli dermatolojik ve metabolik rahatsızlıklarla ilişkilendirilmiştir. Bu çalışmanın amacı, PKOS'lu kadınlarda Demodex türleri enfestasyonu yaygınlığını belirlemek ve antropometrik, hormonal ve glisemik parametrelerle ilişkisini değerlendirmektir. Gereç ve Yöntemler: Bu prospektif gözlemsel çalışmaya, Rotterdam kriterlerine göre doğrulanmış PKOS tanısı almış 18-40 yaş arası 63 kadın dahil edildi. Demodex türlerinin varlığı, standart yüzeyel deri biyopsisi tekniği kullanılarak değerlendirildi. Sosyodemografik veriler, antropometrik ölçümler, over hacmi, oral glukoz tolerans testi sonuçları ve bir dizi hormonal parametre toplandı. Bulgular: Demodex pozitif hastaların vücut kütle indeksi (VKİ), bel ve abdominal çevresi, over hacmi ve açlık kan şekeri düzeyleri anlamlı derecede daha yüksekken, bel-abdominal oranları Demodex negatif hastalara kıyasla daha düşüktü (p<0,05). Buna karşılık, çok değişkenli lojistik regresyon analizi bu parametrelerin hiçbirinin bağımsız olarak anlamlı olmadığını ortaya koydu (p>0,05). Sonuç: Bulgular, PKOS'lu kadınlarda Demodex spp. enfestasyonunun hem dermatolojik hem de metabolik değişiklikleri yansıtabileceğini düşündürmektedir. Tek değişkenli analizler anlamlı ilişkiler gösterse de bunlar çok değişkenli modellerde kalıcı olmamıştır ve bu da daha büyük, prospektif çalışmalara duyulan ihtiyacı vurgulamaktadır. Demodex taraması, özellikle dermatolojik şikayetlerle başvuran hastalarda PKOS'un kapsamlı yönetimine ilişkin ek bilgi sağlayabilir.

Keywords

• Polikistik over sendromu
• demodex türleri
• açlık glikozu
• insülin direnci
• hormonal profil
• over hacmi

Relationship between demodex infestation and clinical parameters in polycystic ovary syndrome: A prospective observational study

Abstract

Aim: Polycystic ovary syndrome (PCOS) is frequently accompanied by dermatologic findings and metabolic disturbances. Because Demodex mites thrive in sebaceous areas and have been linked to several inflammatory and metabolic conditions, we explored whether Demodex positivity is associated with clinical and laboratory features in women with PCOS. Material and Methods: In this prospective observational study, 63 women aged 18–40 years with a confirmed diagnosis of PCOS based on the Rotterdam criteria were enrolled. The presence of Demodex spp. was assessed using the standardized superficial skin biopsy technique. Sociodemographic data, anthropometric measurements, ovarian volume, oral glucose tolerance test results, and a panel of hormonal parameters were collected. Results: Demodex-positive patients had significantly higher body mass index, waist and abdominal circumference, ovarian volume, and fasting glucose levels, while their waist-to- abdominal ratio was lower compared to Demodex-negative patients (p < 0.05). In contrast, multivariate logistic regression analysis revealed that none of these parameters remained independently significant (p > 0.05). Conclusion: The findings suggest that Demodex spp. infestation in women with PCOS may reflect both dermatological and metabolic alterations. Although univariate analyses indicated significant associations, these did not persist in multivariate models, underscoring the need for larger, prospective studies. Screening for Demodex may provide additional insight into the comprehensive management of PCOS, particularly in patients presenting with dermatological complaints.

Keywords

• Polycystic ovary syndrome
• demodex spp.
• fasting glucose
• insulin resistance
• hormonal profile
• ovarian volume

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