Role of Eosinophil Count and Percentage in Chronic Obstructive Pulmonary Disease Exacerbation: A Retrospective Observational Study

Year 2022, Volume: 6 Issue: 3, 352 - 357, 27.12.2022

Ercan Gürlevik Basar Cander Bora Çekmen Serdar Özdemir

https://doi.org/10.29058/mjwbs.1191167

Abstract

Aim: To reveal the role of eosinophil count and percentage evaluated at the time of presentation in
patients hospitalized with the exacerbation of chronic obstructive pulmonary disease (COPD).
Material and Methods: In this study, the data of patients with a diagnosis of the exacerbation of COPD,
who presented to the emergency department, and admitted to the general internal medicine ward, were
retrospectively analyzed. The relationship of eosinophil count and ratios with the length of hospital
stay and intensive care requirement was investigated.The Spearman correlation analysis was used for
investigating correlation between parameters and outcome.
Results: Of the study population, 39.7% were female and 60.3% were male. The ages of the participants
ranged from 25 to 94 years, with a median value of 76 years. There was no significant correlation
between the length of stay in ward and eosinophil count and percentage (rho=-0.148, p=0.066 and
p=0.074, rho=-0.143, respectively) (Spearman correlation test). The group admitted to the intensive
care unit had a significantly higher eosinophil count and percentage of eosinophils than the group that
did not require intensive care (0.81(Inter Quarter Range (IQR):0.41-1.31) versus 1.32 (IQR:0.83-1.43)
p=0.042 and 1.0 (IQR:0.81-1.21) versus 1.42 (IQR:1.02-1.64), p=0.018, respectively) (Mann Whitney
U test).
Conclusion: There was no correlation between a high eosinophil count and percentage and the length
of hospital stay. However, the number and percentage of eosinophils were significantly higher among
the patients requiring intensive care.

Keywords

chronic obstructive pulmonary disease, length of hospital stay, eosinophil, hospitalization, intensive care unit

Kronik Obstrüktif Akciğer Hastalığı Alevlenmesinde Eozinofil Sayısı ve Yüzdesinin Rolü: Bir Gözlemsel Retrospektif Çalışma

Abstract

Amaç: Kronik obstrüktif akciğer hastalığı (KOAH) alevlenmesi ile hastaneye yatırılan hastalarda
başvuru anında değerlendirilen eozinofil sayısı ve yüzdesinin rolünü ortaya çıkarmak.
Gereç ve Yöntemler: Bu çalışmada, acil servise başvuran ve genel dahiliye servisine yatırılan KOAH
alevlenmesi olan 156 hastanın verileri geriye dönük olarak incelendi. Eozinofil sayısı ve oranlarının
hastanede kalış süresi ve yoğun bakım gereksinimi ile ilişkisi araştırıldı. Spearman korelasyon testi ile
sonlanım ile parametreler arası korelasyon araştırıldı.
Bulgular: Çalışma popülasyonunun, %39,7’si kadın ve %60,3’ü erkek idi. Olguların yaşları 25 ile 94 arasında değişmekte olup, medyan değeri 76 idi. Serviste kalış süresi ile eozinofil sayısı ve yüzdesi arasında anlamlı bir ilişki yoktu (sırasıyla rho=-0,148, p=0,066 ve p=0,074, rho=-0,143) (Spearman korelasyon testi). Yoğun bakım ünitesine kabul edilen grup, yoğun bakım gerektirmeyen gruba göre önemli ölçüde daha yüksek eozinofil sayısına ve eozinofil yüzdesine sahipti (0,81(Çeyrekler arası aralık (ÇAA):0,41-1,31)’ e karşı 1,32 (ÇAA:0,83-1,43)
p=0,042 ve 1,0 (ÇAA:0,81-1,21)’e karşı 1,42 (ÇAA:1,02-1,64), p=0,018, sırasıyla).
Sonuç: Yüksek eozinofil sayısı ve yüzdesi ile hastanede kalış süresi arasında ilişki yoktu. Ancak yoğun bakıma ihtiyacı olan hastalarda eozinofil sayısı ve yüzdesi anlamlı olarak daha yüksekti.

Keywords

kronik obstrüktif akciğer hastalığı, hastanede kalış süresi, eozinofil, yoğun bakım ünitesi, hastaneye yatış

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