Research Article
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Evaluation of Factors Associated with Fall History and Fear of Falling in Geriatric Female Patients with Osteoporosis

Year 2023, Volume: 7 Issue: 2, 202 - 210, 31.08.2023
https://doi.org/10.29058/mjwbs.1262316

Abstract

Aim: Fear of falling is a common condition in patients with osteoporosis and leads to a decrease in
physical performance of patients, causing a vicious cycle. The objective of the study was to determine
the frequency of falls, descriptive data regarding falls, and factors associated with falling in female
patients with osteoporosis aged 65 years and over, and to evaluate the factors that may affect fear of
falling (FoF).
Material and Methods: Ninety eight female patients (mean age: 74.0±5.1 years) were evaluated with
descriptive information about fall history and FoF, demographic and clinical data, and routine blood
tests. Falls Efficacy Scale International, hand grip strength, the Rivermead Mobility Index, and the
Douleur Neuropathique 4 questionnaire scores were compared.
Results: 25-hydroxyvitamin D, vitamin B12, and hand grip strength were lower and hemoglobin A1C
level was higher in patients who fell within the last three months (p<0.001, p=0.002, p<0.001, p=0.026,
respectively). All patients who fell had FoF, did not live alone, and did not engage in regular physical
activity. The majority of the patients who fell had previously been diagnosed with osteoporosis (83.3%)
and had poorer sleep quality (p=0.003). Increasing age, late menopause, and living alone had a
significant effect on FoF (p=0.026, p=0.010, p=0.006, respectively).
Conclusion: While falling may be associated with serum vitamin D and B12 levels, muscle strength,
blood glucose level, regular physical activity, having FoF, living alone, poor sleep quality and previously
diagnosed with OP; FoF may be associated with advanced age, age of menopause, and living alone.
These results show that falls and FoF are multifactorial events in geriatric patients with osteoporosis

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References

  • 1. Bergen G, Stevens MR, Burns ER. Falls and fall injuries among adults aged≥ 65 years-United States, 2014. Morb Mortal Wkly Rep 2016;65(37):993-998.
  • 2. Iolascon G, de Sire A, Calafiore D, Benedetti MG, Cisari C, Letizia Mauro G, Migliaccio S, Nuti R, Resmini G, Gonnelli S, Moretti A. Multifactorial assessment of risk of falling in 753 post-menopausal women: a multicenter cross-sectional study by the Italian group for the study of metabolic bone diseases. Clin Interv Aging 2020;15:1077-1084.
  • 3. Gade GV, Jørgensen MG, Ryg J, Riis J, Thomsen K, Masud T, Andersen S. Predicting falls in community-dwelling older adults: a systematic review of prognostic models. BMJ open 2021;11(5):e044170.
  • 4. Smith EM, Shah AA. Screening for geriatric syndromes: falls, urinary/fecal incontinence, and osteoporosis. Clin Geriatr Med 2018;34(1):55-67.
  • 5. Oh‐Park M, Xue X, Holtzer R, Verghese J. Transient versus persistent fear of falling in community‐dwelling older adults: incidence and risk factors. J Am Geriatr Soc 2011;59(7):1225- 1231.
  • 6. Su Q, Gao Y, Zhang J, Tang J, Song M, Song J, Mao Y, Pi H. Prevalence of fear of falling and its association with physical function and fall history among senior citizens living in rural areas of China. Front Public Health 2021;9:766959.
  • 7. Meyer F, König H-H, Hajek A. Osteoporosis, fear of falling, and restrictions in daily living. Evidence from a nationally representative sample of community-dwelling older adults. Front Endocrinol 2019;10:646.
  • 8. Camacho PM, Petak SM, Binkley N, Diab DL, Eldeiry LS, Farooki A, Harris ST, Hurley DL, Kelly J, Lewiecki EM, Pessah- Pollack R, McClung M, Wimalawansa SJ, Watts NB. American Association of Clinical Endocrinologists/American College of Endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis-2020 update. Endocr Pract 2020;26(Suppl 1):1-46.
  • 9. Cha YH, Ha Y-C, Lim J-Y, Kim W-S. Introduction of the cost-effectiveness studies of fracture liaison service in other countries. J Bone Metab 2020;27(2):79-83.
  • 10. Hita-Contreras F, Martínez-López E, González-Matarín P, Mendoza N, Cruz-Díaz D, Ruiz-Ariza A, Martínez-Amat A. Association of bone mineral density with postural stability and the fear of falling in Spanish postmenopausal women. Maturitas 2014;79(3):322-328.
  • 11. Liu M, Hou T, Li Y, Sun X, Szanton SL, Clemson L, Davidson PM. Fear of falling is as important as multiple previous falls in terms of limiting daily activities: a longitudinal study. BMC Geriatr 2021;21(1):350.
  • 12. Beserra Da Silva R, Costa-Paiva L, Siani Morais S, Mezzalira R, Oliveira Ferreira ND, Mendes Pinto-Neto A. Predictors of falls in women with and without osteoporosis. Orthop Sports Phys Ther 2010;40(9):582-588.
  • 13. Sinaki M, Brey RH, Hughes CA, Larson DR, Kaufman KR. Balance disorder and increased risk of falls in osteoporosis and kyphosis: significance of kyphotic posture and muscle strength. Osteoporos Int 2005;16(8):1004-1010.
  • 14. Möckel L. Risk of falls in patients with low bone mineral density : Analysis of placebo arms from clinical trials. Z Gerontol Geriatr 2021;54(6):576-581.
  • 15. Resnick B, Nahm ES, Zhu S, Brown C, An M, Park B, Brown J. The impact of osteoporosis, falls, fear of falling and efficacy expectations on exercise among community dwelling older adults. Orthop Nurs 2014;33(5):277-288.
  • 16. Hübscher M, Vogt L, Schmidt K, Fink M, Banzer W. Perceived pain, fear of falling and physical function in women with osteoporosis. Gait Posture 2010;32(3):383-385.
  • 17. Mehrholz J, Wagner K, Rutte K, Meiβner D, Pohl M. Predictive validity and responsiveness of the functional ambulation category in hemiparetic patients after stroke. Arch Phys Med Rehabil 2007;88(10):1314-1319.
  • 18. Organization WH, Ageing WHO, Unit LC. WHO global report on falls prevention in older age. World Health Organization; 2008.
  • 19. Lurie JD, Zagaria AB, Pidgeon DM, Forman JL, Spratt KF. Pilot comparative effectiveness study of surface perturbation treadmill training to prevent falls in older adults. BMC Geriatr 2013,13:49.
  • 20. Ulus Y, Durmus D, Akyol Y, Terzi Y, Bilgici A, Kuru O. Reliability and validity of the Turkish version of the Falls Efficacy Scale International (FES-I) in community-dwelling older persons. Arch Gerontol Geriatr 2012;54(3):429-433.
  • 21. Trampisch US, Franke J, Jedamzik N, Hinrichs T, Platen P. Optimal Jamar dynamometer handle position to assess maximal isometric hand grip strength in epidemiological studies. J Hand Surg Am 2012;37(11):2368-2373.
  • 22. Akin B, Emiroglu ON. Rivermead Mobilite Indexi (RMI) Turkce formunun yaslilarda gecerlilik ve guvenilirligi. Turk Geriatri Dergisi 2007;10:124-130.
  • 23. Unal-Cevik I, Sarioglu-Ay S, Evcik D. A comparison of the DN4 and LANSS questionnaires in the assessment of neuropathic pain: validity and reliability of the Turkish version of DN4. J Pain 2010;11(11):1129-1135.
  • 24. Pua Y-H, Ong P-H, Lim EC-W, Huang KS, Clark RA, Chandran M. Functional heterogeneity and outcomes in communitydwelling women with osteoporosis, with and without a history of falls. Gait Posture 2014;39(3):971-977.
  • 25. Ganz DA, Higashi T, Rubenstein LZ. Monitoring falls in cohort studies of community‐dwelling older people: effect of the recall interval. J Am Geriatr Soc 2005;53(12):2190-2194.
  • 26. Stevens JA, Ballesteros MF, Mack KA, Rudd RA, DeCaro E, Adler G. Gender differences in seeking care for falls in the aged Medicare population. Am J Prev Med 2012;43(1):59-62.
  • 27. Barrett-Connor E, Weiss T, McHorney C, Miller P, Siris E. Predictors of falls among postmenopausal women: results from the National Osteoporosis Risk Assessment (NORA). Osteoporos Int 2009;20(5):715-722.
  • 28. Pfeifer M, Begerow B, Minne HW, Schlotthauer T, Pospeschill M, Scholz M, Lazarescu AD, Pollähne W. Vitamin D status, trunk muscle strength, body sway, falls, and fractures among 237 postmenopausal women with osteoporosis. Exp Clin Endocrinol Diabetes 2001;109(2):87-92.
  • 29. Ling Y, Xu F, Xia X, Dai D, Xiong A, Sun R, Qiu L, Xie Z. Vitamin D supplementation reduces the risk of fall in the vitamin D deficient elderly: An updated meta-analysis. Clin Nutr 2021;40(11):5531-5537.
  • 30. Flicker L, MacInnis RJ, Stein MS, Scherer SC, Mead KE, Nowson CA, Thomas J, Lowndes C, Hopper JL, Wark JD. Should older people in residential care receive vitamin D to prevent falls? Results of a randomized trial. J Am Geriatr Soc 2005;53(11):1881-1888.
  • 31. Lewerin C, Nilsson-Ehle H, Jacobsson S, Johansson H, Sundh V, Karlsson MK, Ljunggren Ö, Lorentzon M, Kanis JA, Lerner UH, Cummings SR, Ohlsson C, Mellström D. Low holotranscobalamin and cobalamins predict incident fractures in elderly men: the MrOS Sweden. Osteoporos Int 2014;25(1):131-140.
  • 32. Dhonukshe‐Rutten RA, Pluijm SM, De Groot LC, Lips P, Smit JH, Van Staveren WA. Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people. J Bone Miner Res 2005;20(6):921-929.
  • 33. Takada S, Yamamoto Y, Shimizu S, Kimachi M, Ikenoue T, Fukuma S, Onishi Y, Takegami M, Yamazaki S, Ono R, Sekiguchi M, Otani K, Kikuchi SI, Konno SI, Fukuhara S. Association between subjective sleep quality and future risk of falls in older people: results from LOHAS. J Gerontol A Biol Sci Med Sci 2018;73(9):1205-1211.
  • 34. Stone KL, Ancoli-Israel S, Blackwell T, Ensrud KE, Cauley JA, Redline S, Hillier TA, Schneider J, Claman D, Cummings SR. Actigraphy-measured sleep characteristics and risk of falls in older women. Arch Intern Med 2008;168(16):1768-1775.
  • 35. Cangussu LM, Nahas-Neto J, Nahas EAP, Barral ABCR, de Araujo Buttros D, Uemura G. Evaluation of postural balance in postmenopausal women and its relationship with bone mineral density-a cross sectional study. BMC Musculoskelet Disord 2012;13:2.
  • 36. Nachreiner NM, Findorff MJ, Wyman JF, McCarthy TC. Circumstances and consequences of falls in communitydwelling older women. J Womens Health (Larchmt) 2007;16(10):1437-1446.
  • 37. Clemson L, Kendig H, Mackenzie L, Browning C. Predictors of injurious falls and fear of falling differ: an 11-year longitudinal study of incident events in older people. J Aging Health 2015;27(2):239-256.
  • 38. Elliott S, Painter J, Hudson S. Living alone and fall risk factors in community-dwelling middle age and older adults. J Community Health 2009;34(4):301-310.

Osteoporozu Olan Geriatrik Kadın Hastalarda Düşme Öyküsü ve Düşme Korkusu ile İlişkili Faktörlerin Değerlendirilmesi

Year 2023, Volume: 7 Issue: 2, 202 - 210, 31.08.2023
https://doi.org/10.29058/mjwbs.1262316

Abstract

Amaç: Osteoporozlu hastalarda düşme korkusu sık görülen bir durumdur ve hastaların fiziksel
performanslarında azalmaya yol açarak kısır bir döngüye yol açar. Bu çalışmanın amacı, 65 yaş ve üstü
osteoporozu olan kadın hastalarda, düşme sıklığını, düşmeye ilişkin tanımlayıcı verileri, düşme ile ilişkili
faktörleri belirlemek ve düşme korkusunu etkileyebilecek faktörleri değerlendirmektir.
Gereç ve Yöntemler: Doksan sekiz kadın hasta (yaş ortalaması: 74.0±5.1) , düşme öyküsü ve düşme
korkusuna ilişkin tanımlayıcı bilgiler, demografik ve klinik veriler ve rutin kan testleri ile değerlendirildi.
Hastaların Uluslararası Düşme Etkinliği Ölçeği, el kavrama gücü, Rivermead Mobilite İndeksi ve Douleur
Neuropathique 4 anket puanları karşılaştırıldı.
Bulgular: Son üç ay içinde düşen hastalarda 25-hidroksivitamin D, vitamin B12 ve el kavrama kuvveti
daha düşük, hemoglobin A1C düzeyi daha yüksekti (sırasıyla, p<0.001, p=0.002, p<0.001, p=0.026).Düşen hastaların tamamında düşme korkusu vardı, düşen tüm hastalar evde yalnız yaşamıyor ve düzenli fiziksel aktivite yapmıyordu. Düşen
hastaların çoğuna (%83.3) daha önceden osteoporoz tanısı konmuştu ve uyku kaliteleri daha kötüydü (p=0.003). Yaşın ilerlemesi, geç
menopoz ve yalnız yaşama düşme korkusu üzerinde anlamlı bir etkiye sahipti (sırasıyla, p=0.026, p=0.010, p=0.006).
Sonuç: Düşme, serum D ve B12 vitamini düzeyi, kas gücü, kan glikoz düzeyi, düzenli fiziksel aktivite, düşme korkusu, yalnız yaşama, kötü
uyku kalitesi ve önceden osteoporoz tanısı almış olma ile ilişkili olabilirken; düşme korkusu, ileri yaş, menopoz yaşı ve yalnız yaşama ile
ilişkili olabilir. Bu sonuçlar düşme ve düşme korkusunun osteoporozu olan geriatrik hastalarda çok faktörlü olaylar olduğunu göstermektedir

Project Number

N/A

References

  • 1. Bergen G, Stevens MR, Burns ER. Falls and fall injuries among adults aged≥ 65 years-United States, 2014. Morb Mortal Wkly Rep 2016;65(37):993-998.
  • 2. Iolascon G, de Sire A, Calafiore D, Benedetti MG, Cisari C, Letizia Mauro G, Migliaccio S, Nuti R, Resmini G, Gonnelli S, Moretti A. Multifactorial assessment of risk of falling in 753 post-menopausal women: a multicenter cross-sectional study by the Italian group for the study of metabolic bone diseases. Clin Interv Aging 2020;15:1077-1084.
  • 3. Gade GV, Jørgensen MG, Ryg J, Riis J, Thomsen K, Masud T, Andersen S. Predicting falls in community-dwelling older adults: a systematic review of prognostic models. BMJ open 2021;11(5):e044170.
  • 4. Smith EM, Shah AA. Screening for geriatric syndromes: falls, urinary/fecal incontinence, and osteoporosis. Clin Geriatr Med 2018;34(1):55-67.
  • 5. Oh‐Park M, Xue X, Holtzer R, Verghese J. Transient versus persistent fear of falling in community‐dwelling older adults: incidence and risk factors. J Am Geriatr Soc 2011;59(7):1225- 1231.
  • 6. Su Q, Gao Y, Zhang J, Tang J, Song M, Song J, Mao Y, Pi H. Prevalence of fear of falling and its association with physical function and fall history among senior citizens living in rural areas of China. Front Public Health 2021;9:766959.
  • 7. Meyer F, König H-H, Hajek A. Osteoporosis, fear of falling, and restrictions in daily living. Evidence from a nationally representative sample of community-dwelling older adults. Front Endocrinol 2019;10:646.
  • 8. Camacho PM, Petak SM, Binkley N, Diab DL, Eldeiry LS, Farooki A, Harris ST, Hurley DL, Kelly J, Lewiecki EM, Pessah- Pollack R, McClung M, Wimalawansa SJ, Watts NB. American Association of Clinical Endocrinologists/American College of Endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis-2020 update. Endocr Pract 2020;26(Suppl 1):1-46.
  • 9. Cha YH, Ha Y-C, Lim J-Y, Kim W-S. Introduction of the cost-effectiveness studies of fracture liaison service in other countries. J Bone Metab 2020;27(2):79-83.
  • 10. Hita-Contreras F, Martínez-López E, González-Matarín P, Mendoza N, Cruz-Díaz D, Ruiz-Ariza A, Martínez-Amat A. Association of bone mineral density with postural stability and the fear of falling in Spanish postmenopausal women. Maturitas 2014;79(3):322-328.
  • 11. Liu M, Hou T, Li Y, Sun X, Szanton SL, Clemson L, Davidson PM. Fear of falling is as important as multiple previous falls in terms of limiting daily activities: a longitudinal study. BMC Geriatr 2021;21(1):350.
  • 12. Beserra Da Silva R, Costa-Paiva L, Siani Morais S, Mezzalira R, Oliveira Ferreira ND, Mendes Pinto-Neto A. Predictors of falls in women with and without osteoporosis. Orthop Sports Phys Ther 2010;40(9):582-588.
  • 13. Sinaki M, Brey RH, Hughes CA, Larson DR, Kaufman KR. Balance disorder and increased risk of falls in osteoporosis and kyphosis: significance of kyphotic posture and muscle strength. Osteoporos Int 2005;16(8):1004-1010.
  • 14. Möckel L. Risk of falls in patients with low bone mineral density : Analysis of placebo arms from clinical trials. Z Gerontol Geriatr 2021;54(6):576-581.
  • 15. Resnick B, Nahm ES, Zhu S, Brown C, An M, Park B, Brown J. The impact of osteoporosis, falls, fear of falling and efficacy expectations on exercise among community dwelling older adults. Orthop Nurs 2014;33(5):277-288.
  • 16. Hübscher M, Vogt L, Schmidt K, Fink M, Banzer W. Perceived pain, fear of falling and physical function in women with osteoporosis. Gait Posture 2010;32(3):383-385.
  • 17. Mehrholz J, Wagner K, Rutte K, Meiβner D, Pohl M. Predictive validity and responsiveness of the functional ambulation category in hemiparetic patients after stroke. Arch Phys Med Rehabil 2007;88(10):1314-1319.
  • 18. Organization WH, Ageing WHO, Unit LC. WHO global report on falls prevention in older age. World Health Organization; 2008.
  • 19. Lurie JD, Zagaria AB, Pidgeon DM, Forman JL, Spratt KF. Pilot comparative effectiveness study of surface perturbation treadmill training to prevent falls in older adults. BMC Geriatr 2013,13:49.
  • 20. Ulus Y, Durmus D, Akyol Y, Terzi Y, Bilgici A, Kuru O. Reliability and validity of the Turkish version of the Falls Efficacy Scale International (FES-I) in community-dwelling older persons. Arch Gerontol Geriatr 2012;54(3):429-433.
  • 21. Trampisch US, Franke J, Jedamzik N, Hinrichs T, Platen P. Optimal Jamar dynamometer handle position to assess maximal isometric hand grip strength in epidemiological studies. J Hand Surg Am 2012;37(11):2368-2373.
  • 22. Akin B, Emiroglu ON. Rivermead Mobilite Indexi (RMI) Turkce formunun yaslilarda gecerlilik ve guvenilirligi. Turk Geriatri Dergisi 2007;10:124-130.
  • 23. Unal-Cevik I, Sarioglu-Ay S, Evcik D. A comparison of the DN4 and LANSS questionnaires in the assessment of neuropathic pain: validity and reliability of the Turkish version of DN4. J Pain 2010;11(11):1129-1135.
  • 24. Pua Y-H, Ong P-H, Lim EC-W, Huang KS, Clark RA, Chandran M. Functional heterogeneity and outcomes in communitydwelling women with osteoporosis, with and without a history of falls. Gait Posture 2014;39(3):971-977.
  • 25. Ganz DA, Higashi T, Rubenstein LZ. Monitoring falls in cohort studies of community‐dwelling older people: effect of the recall interval. J Am Geriatr Soc 2005;53(12):2190-2194.
  • 26. Stevens JA, Ballesteros MF, Mack KA, Rudd RA, DeCaro E, Adler G. Gender differences in seeking care for falls in the aged Medicare population. Am J Prev Med 2012;43(1):59-62.
  • 27. Barrett-Connor E, Weiss T, McHorney C, Miller P, Siris E. Predictors of falls among postmenopausal women: results from the National Osteoporosis Risk Assessment (NORA). Osteoporos Int 2009;20(5):715-722.
  • 28. Pfeifer M, Begerow B, Minne HW, Schlotthauer T, Pospeschill M, Scholz M, Lazarescu AD, Pollähne W. Vitamin D status, trunk muscle strength, body sway, falls, and fractures among 237 postmenopausal women with osteoporosis. Exp Clin Endocrinol Diabetes 2001;109(2):87-92.
  • 29. Ling Y, Xu F, Xia X, Dai D, Xiong A, Sun R, Qiu L, Xie Z. Vitamin D supplementation reduces the risk of fall in the vitamin D deficient elderly: An updated meta-analysis. Clin Nutr 2021;40(11):5531-5537.
  • 30. Flicker L, MacInnis RJ, Stein MS, Scherer SC, Mead KE, Nowson CA, Thomas J, Lowndes C, Hopper JL, Wark JD. Should older people in residential care receive vitamin D to prevent falls? Results of a randomized trial. J Am Geriatr Soc 2005;53(11):1881-1888.
  • 31. Lewerin C, Nilsson-Ehle H, Jacobsson S, Johansson H, Sundh V, Karlsson MK, Ljunggren Ö, Lorentzon M, Kanis JA, Lerner UH, Cummings SR, Ohlsson C, Mellström D. Low holotranscobalamin and cobalamins predict incident fractures in elderly men: the MrOS Sweden. Osteoporos Int 2014;25(1):131-140.
  • 32. Dhonukshe‐Rutten RA, Pluijm SM, De Groot LC, Lips P, Smit JH, Van Staveren WA. Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people. J Bone Miner Res 2005;20(6):921-929.
  • 33. Takada S, Yamamoto Y, Shimizu S, Kimachi M, Ikenoue T, Fukuma S, Onishi Y, Takegami M, Yamazaki S, Ono R, Sekiguchi M, Otani K, Kikuchi SI, Konno SI, Fukuhara S. Association between subjective sleep quality and future risk of falls in older people: results from LOHAS. J Gerontol A Biol Sci Med Sci 2018;73(9):1205-1211.
  • 34. Stone KL, Ancoli-Israel S, Blackwell T, Ensrud KE, Cauley JA, Redline S, Hillier TA, Schneider J, Claman D, Cummings SR. Actigraphy-measured sleep characteristics and risk of falls in older women. Arch Intern Med 2008;168(16):1768-1775.
  • 35. Cangussu LM, Nahas-Neto J, Nahas EAP, Barral ABCR, de Araujo Buttros D, Uemura G. Evaluation of postural balance in postmenopausal women and its relationship with bone mineral density-a cross sectional study. BMC Musculoskelet Disord 2012;13:2.
  • 36. Nachreiner NM, Findorff MJ, Wyman JF, McCarthy TC. Circumstances and consequences of falls in communitydwelling older women. J Womens Health (Larchmt) 2007;16(10):1437-1446.
  • 37. Clemson L, Kendig H, Mackenzie L, Browning C. Predictors of injurious falls and fear of falling differ: an 11-year longitudinal study of incident events in older people. J Aging Health 2015;27(2):239-256.
  • 38. Elliott S, Painter J, Hudson S. Living alone and fall risk factors in community-dwelling middle age and older adults. J Community Health 2009;34(4):301-310.
There are 38 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Article
Authors

Alper Mengi 0000-0003-0898-764X

Emre Sualp 0000-0001-7423-2267

Project Number N/A
Publication Date August 31, 2023
Acceptance Date August 6, 2023
Published in Issue Year 2023 Volume: 7 Issue: 2

Cite

Vancouver Mengi A, Sualp E. Evaluation of Factors Associated with Fall History and Fear of Falling in Geriatric Female Patients with Osteoporosis. Med J West Black Sea. 2023;7(2):202-10.

Medical Journal of Western Black Sea is a scientific publication of Zonguldak Bulent Ecevit University Faculty of Medicine.

This is a refereed journal, which aims at achieving free knowledge to the national and international organizations and individuals related to medical sciences in publishedand electronic forms.

This journal is published three annually in April, August and December.
The publication language of the journal is Turkish and English.