Tiroid Göz Hastalığında Henle Sinir Lifi Tabakasının Optik Koherens Tomografi ile Değerlendirilmesi

Year 2024, Volume: 8 Issue: 3, 341 - 347, 30.12.2024

Mehmet Fatih Kağan Değirmenci , Nazan Acar Eser

Abstract

Amaç: Tiroid Göz Hastalığı (TGH) olan bireylerde, fotoreseptör ve Müller hücrelerinden oluşan Henle sinir lifi tabakasının (HSLT) optik
koherens tomografi (OKT) ile değerlendirilerek sağlıklı bireylerde kıyaslanması amaçlanmıştır.
Gereç ve Yöntemler: İnaktif hafif seviyede TGH olan 20 hastanın 20 gözü (Grup-1) ile yaş ve cinsiyet uyumlu 20 sağlıklı katılımcının 20
gözü (Grup-2) retrospektif olarak çalışmaya dahil edildi. Tüm katılımcıların detaylı göz muayene bulguları kaydedildi. OKT ile elde edilen
retinal kalınlıkları ve ImageJ programı yardımıyla ölçülen santral 500 ve 1000 μm genişlikteki HSLT alanı ölçülerek kaydedildi. Bulgular iki
grup arasında istatistiksel olarak kıyaslandı.
Bulgular: Gruplar arasında ortalama yaş ve cinsiyet dağılımı açısından anlamlı fark saptanmadı (p>0,05). En iyi düzeltilmiş görme keskinliği,
göz içi basıncı, sferik eşdeğer, aksiyel uzunluk ve ön kamara derinliği ortalamaları iki grup arasında benzerdi (tümü için p>0,05). Retinal
kalınlık ve koroid kalınlığı açısından da iki grup arasında istatistiksel anlamlı fark görülmedi (p>0,05). Ortalama HSLT alanı santral 500
μm’lik bölgede Grup-1’de anlamlı olarak daha yüksekti (Grup-1: 25678,4 ± 5372,0 μm2 vs. Grup-2: 23375,0 ± 3974,5 μm2, p=0,010). Santral
1000 μm’lik bölgede ise iki grup arasında ortalama HSLT alanları benzerdi (Grup-1: 99859,9 ± 9936,4 μm2 vs Grup-2: 97563 ± 8478,4 μm2,
p=0,090).
Sonuç: Çalışmamızın bulguları, hafif dereceli ve inaktif dönemdeki TGH olan gözlerde santral foveal bölgede fotoreseptör ve Müller
hücrelerinden oluşan HSLT alanında artış olduğunu göstermektedir. HSLT’nin değerlendirilmesi TGH’nin erken tanınması ve takibi için ümit
vericidir.

Keywords

Fotoreseptör hücre, Henle sinir lifi tabakası, Müller hücresi, tiroid göz hastalığı

Evaluation of Henle Nerve Fiber Layer by Optical Coherence Tomography in Thyroid Eye Disease

Abstract

Aim: The aim of this study was to evaluate the Henle's nerve fiber layer (HNFL) consisting of photoreceptors and Müller cells in individuals
with Thyroid Eye Disease (TED) using optical coherence tomography (OCT) and to compare it with healthy individuals.
Material and Methods: Twenty eyes of 20 patients with inactive mild TED (Group-1) and 20 eyes of 20 age- and gender-matched healthy
participants (Group-2) were retrospectively included in the study. Detailed ocular examination findings of all participants were recorded.
Retinal thickness obtained by OCT and central 500 and 1000 μm wide HNFL area, measured by ImageJ software, were recorded. The
findings were statistically compared between the two groups.
Results: There was no significant difference in mean age and gender distribution between the groups (p>0.05). Mean best corrected visual
acuity, intraocular pressure, spherical equivalent, axial length and anterior chamber depth were similar between the two groups (p>0.05 for
all). Retinal thickness and choroidal thickness were not significantly different between the two groups (p>0.05). The mean HNFL area in the
central 500 μm region was significantly higher in group-1 than in group-2 (Group-1: 25678,4 ± 5372,0 μm2 vs. group-2: 23375,0 ± 3974,5
μm2, p=0.010). In the central 1000 μm region, the mean HSLT areas were similar between the two groups (Group-1: 99859,9 ± 9936,4 μm2
vs group-2: 97563,0 ± 8478,4 μm2, p=0.090).
Conclusion: The findings of our study show an increased HNFL area consisting of photoreceptors and Müller cells in the central foveal
region in eyes with mild and inactive TED. Evaluation of HNFL may be promising for early detection and follow-up of TED

Keywords

Henle, Müller cell, photoreceptor cell, thyroid eye disease

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