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Rüptüre Abdominal Aort Anevrizmasında Zamanla Yarış: Hayatta Kalma ve Tedavi Sonuçlarının Retrospektif Analizi

Year 2024, Volume: 8 Issue: 3, 355 - 362, 30.12.2024

Abstract

Amaç: Rüptüre abdominal aort anevrizmaları (rAAA) operasyon öncesi ve sonrası yüksek mortaliteye sahip acil cerrahi bir durumdur. Bu
çalışmanın amacı acil cerrahi tedavi edilen infrarenal abdominal aort anevrizmalarında operasyon öncesi, sırası ve sonrası mortaliteye etki
eden faktörlerin araştırılmasıdır
Gereç ve Yöntemler: Abdominal aort anevrizma rüptürü tanısı ile 2019-2024 yılları arasında acil ve açık cerrahi ile opere edilen 38 hasta
[erkek 34(%89,4), kadın 4(%10,6)] çalışmaya alınmıştır. Hastaların operasyon öncesi ve operasyon sonrası demografik özellikleri retrospektif
olarak incelenmiştir. Semptomların başlamasından sonra tedavi amaçlı gidilen hastanelere göre hastalar iki gruba ayrıldı. Acil servisimize
başvuran veya ambulans ile getirilen hastalar Grup-1 (n=17) ve dış merkezlerden tanı konulup tarafımıza refere edilen hastalar Grup-2
(n=21) olarak ayrıldılar.
Bulgular: Çalışmaya alınan 38 hastanın yaş ortalaması 63,57 ± 13,62 yıldı. Hastaların 34’ü erkek ve dördü kadındı. Eşlik eden risk faktörleri
kronik obstrüktif akciğer hastalığı (n=17, %50), diyabet (n=25, %65,7), hipertansiyon (n=33, %86,8), hiperlipidemi (n=35, %92,1) ve akut
böbrek yetersizliği (n=4, %10,5) idi. Toplam 9 (%23,6) hasta kaybedildi. Mortal seyreden hastaların hepsi yoğun bakım takipleri sırasında
(10 ± 9,6 gün) kaybedildi. Hastanemiz bölgeye hitap etmesi nedeniyle çevre illerden sevk edilen hastalarda mortalite daha yüksek görüldü.
Dokuz hastanın yedisi dış merkezde tanı konularak sevk edilen hastalardı. Mortalite sebepleri renal yetersizlik, multiorgan yetersizliği,
respiratuvar distrest sendromu ve sepsis olarak görüldü.
Sonuç: Karın ağrısı nedeniyle acil servise başvuran hastaların rAAA tanısı konulduktan sonra mümkün olan en kısa sürede opere edildiğinde
ölüm oranlarında önemli oranda azalma görülmektedir. Hipotansiyon, yüksek üre ve kreatinin seviyeleri, kan kaybı, yetersiz kan ve mayi
verilmesi, bilinç kaybı, kardiyak arrest operasyon öncesi mortaliteyi arttırıcı nedenlerdir. Kısa süren aortik kross klemp süresi, intraoperatif
kan kaybının minimum seviyeye indirilmesi, hastaları operasyon sırasında düşük tansiyondan korumak ve iyi bir diürez ile sağ kalım oranı
yükselmektedir.

References

  • 1. Booher AM, Eagle KA. Diagnosis and management issues in thoracic aortic aneurysm. American Heart Journal, 2011;162(1):38-46.
  • 2. Aggarwal S, Qamar A, Sharma V, Sharma A. Abdominal aortic aneurysm: A comprehensive review. Experimental & Clinical Cardiology, 2011;16(1):11.
  • 3. Sidloff DA, Saratzis A, Thompson J, Katsogridakis E, Bown MJ. Infra-renal aortic diameter and cardiovascular risk: Making better use of abdominal aortic aneurysm screening outcomes. Journal of Vascular Surgery, 2021;74(2):679-680.
  • 4. Guo DC, Papke CL, He R, Milewicz DM. Pathogenesis of thoracic and abdominal aortic aneurysms. Annals of the New York Academy of Sciences, 2006;1085(1):339-352.
  • 5. Song Q, Guo Y, Huo Z, Wang M, Sun X, Zhou Z, Wu X. Analysis of high-risk factors and mortality prediction of ruptured abdominal aortic aneurysm. Annals of Vascular Surgery, 2024;109:91- 100.
  • 6. Haller SJ, Azarbal AF, Rugonyi S. Predictors of abdominal aortic aneurysm risks. Bioengineering, 2020;7(3):79.
  • 7. Castro-Ferreira R, Vidoedo J, Peixoto J, Canedo A, Teixeira J, Leite-Moreira A, Sampaio S. Incidental abdominal aortic aneurysms are largely undocumented and unmonitored. Annals of Vascular Surgery, 2021;77:182-186.
  • 8. Rezaeitaleshmahalleh M, Sunderland KW, Lyu Z, Johnson T, King K, Liedl DA, Jiang J. Computerized differentiation of growth status for abdominal aortic aneurysms: A feasibility study. Journal of Cardiovascular Translational Research, 2023;16(4):874-885.
  • 9. Cherian AM, Venu R, Raja PI, Saravanan S, Khan U, Kantawala R, Sharma A. Outcomes of endovascular aneurysm repair (EVAR) compared to open repair in abdominal aortic aneurysm: An umbrella meta-analysis. Cureus, 2024;16(6).
  • 10. Steyerberg EW, Kievit J, Van Otterloo JADM, van Bockel JH, Eijkemans MJ, Habbema JDF. Perioperative mortality of elective abdominal aortic aneurysm surgery: A clinical prediction rule based on literature and individual patient data. Archives of Internal Medicine, 1995;155(18):1998-2004.
  • 11. Sharma A, Sethi P, Gupta K. Endovascular abdominal aortic aneurysm repair. Interventional Cardiology Clinics, 2020;9(2):153-168.
  • 12. Smidfelt K, Nordanstig J, Davidsson A, Törngren K, Langenskiöld M. Misdiagnosis of ruptured abdominal aortic aneurysms is common and is associated with increased mortality. Journal of Vascular Surgery, 2021;73(2):476-483.
  • 13. Fattahi N, Rosenblad A, Kragsterman B, Hultgren R. Risk factors in 50-year-old men predicting development of abdominal aortic aneurysm. Journal of Vascular Surgery, 2020;72(4):1337- 1346.
  • 14. Urbonavicius S, Urbonaviciene G, Honoré B, Henneberg EW, Vorum H, Lindholt JS. Potential circulating biomarkers for abdominal aortic aneurysm expansion and rupture: A systematic review. European Journal of Vascular and Endovascular Surgery, 2008;36(3):273-280.
  • 15. Ernst CB. Abdominal aortic aneurysm. New England Journal of Medicine, 1993;328(16):1167-1172.
  • 16. Blakemore AH, Voorhees AB Jr. Aneurysm of the aorta: A review of 365 cases. Angiology, 1954;5(3):209-231.
  • 17. Summers KL, Kerut EK, Sheahan CM, Sheahan MG III. Evaluating the prevalence of abdominal aortic aneurysms in the United States through a national screening database. Journal of Vascular Surgery, 2021;73(1):61-68.
  • 18. Talvitie, M. Abdominal Aortic Aneurysms: Sex and Gender Disparities in Surveillance, Treatment and Outcome. Karolinska Institutet (Sweden). 2023
  • 19. Aggarwal S, Qamar A, Sharma V, Sharma A. Abdominal aortic aneurysm: A comprehensive review. Experimental & Clinical Cardiology, 2011;16(1):11.
  • 20. Brown LC, Powell JT. Risk factors for aneurysm rupture in patients kept under ultrasound surveillance. UK Small Aneurysm Trial Participants. Annals of Surgery, 1999;230(3):289-296.
  • 21. Chun KC, Dolan KJ, Smothers HC, Irwin ZT, Anderson RC, Gonzalves AL, Lee ES. The 10-year outcomes of a regional abdominal aortic aneurysm screening program. J Vasc Surg. 2019 Oct;70(4):1123-1129.
  • 22. Pál D, Szilágyi B, Berczeli M, Szalay CI, Sárdy B, Oláh Z, Sótonyi P. Ruptured aortic aneurysm and dissection related death: An autopsy database analysis. Pathology & Oncology Research, 2020;26:2391-2399.
  • 23. Smidfelt K, Nordanstig J, Davidsson A, Törngren K, Langenskiöld M. Misdiagnosis of ruptured abdominal aortic aneurysms is common and is associated with increased mortality. Journal of Vascular Surgery, 2021;73(2):476-483.
  • 24. Haveman JW, Zeebregts CJ, Verhoeven EL, van den Berg P, van den Dungen JJ, Zwaveling JH, Nijsten MW. Changes in laboratory values and their relationship with time after rupture of an abdominal aortic aneurysm. Surgery Today, 2008;38:1091- 1101.
  • 25. Tang Y, Chen J, Huang K, Luo D, Liang P, Feng M, Xu A. The incidence, risk factors and in-hospital mortality of acute kidney injury in patients after abdominal aortic aneurysm repair surgery. BMC Nephrology, 2017;18:1-8.
  • 26. Kim SD, Hwang JK, Park SC, Kim JI, Moon IS, Park JS, Yun SS. Predictors of postoperative mortality of ruptured abdominal aortic aneurysm: a retrospective clinical study. Yonsei Med J. 2012 Jul 1;53(4):772-80.
  • 27. Rutledge R, Oller DW, Meyer AA, Johnson GJ Jr. A statewide, population-based time-series analysis of the outcome of ruptured abdominal aortic aneurysm. Ann Surg 1996;223:492-502.
  • 28. Howard DPJ, Banerjee A, Fairhead JF, Handa A, Silver LE, Rothwell PM. Age-specific incidence, risk factors and outcome of acute abdominal aortic aneurysms in a defined population. British Journal of Surgery, 2015;102(8):907-915.
  • 29. Cho MJ, Yoon HJ, Park JY, Huh S, Kim YW. The risk factors influencing postoperative mortality in the patients with ruptured abdominal aortic aneurysm. J Korean Soc Vasc Surg 2004;20:208-13.
  • 30. Roberts K, Revell M, Youssef H, Bradbury AW, Adam DJ. Hypotensive resuscitation in patients with ruptured abdominal aortic aneurysm. Eur J Vasc Endovasc Surg 2006;31:339-44

Race Over Time in Ruptured Abdominal Aortic Aneurysm: A Retrospective Analysis of Survival and Treatment Outcomes

Year 2024, Volume: 8 Issue: 3, 355 - 362, 30.12.2024

Abstract

Aim: Ruptured abdominal aortic aneurysms (rAAA) are a surgical emergency with high pre- and postoperative mortality. The aim of this
study was to investigate the factors affecting preoperative, intraoperative and postoperative mortality in infrarenal abdominal aortic aneurysms
treated with emergency surgery.
Material and Methods: Thirty-eight patients [male 34 (89.4%), female 4 (10.6%)] who underwent emergency and open surgery for ruptured
abdominal aortic aneurysm between 2019 and 2024 were included in the study. Preoperative and postoperative demographic characteristics
of the patients were retrospectively analyzed. Patients were divided into two groups according to the hospitals visited for treatment after the
onset of symptoms. Patients admitted to our emergency department or brought by ambulance were divided into Group-1 (n=17) and patients
diagnosed from external centers and consulted to us were divided into Group-2 (n=21).
Results: The mean age of the 38 patients included in the study was 63.57 ± 13.62 years. 34 of the patients were male (89.4%) and four were
female (10.6%). Concomitant risk factors were chronic obstructive pulmonary disease (n=17, 50%), diabetes (n=25, 65.7%), hypertension (n=33, 86.8%), hyperlipidemia (n=35, 92.1%) and acute renal failure (n=4, 10.5%). A total of 9 (23.6%) patients died. All mortal patients died
during intensive care unit follow-up (10 ± 9.6 days). Since our hospital is located in the region, mortality was higher in patients referred from
neighboring provinces. Of the nine patients, seven were referred after being diagnosed in an external center. The causes of mortality were
renal failure, multiorgan failure, respiratory distress syndrome and sepsis.
Conclusion: When patients presenting to the emergency department with abdominal pain are operated as soon as possible after the
diagnosis of rAAA, there is a significant reduction in motrality rates. Hypotension, high urea and creatinine levels, blood loss, inadequate
blood and fluid administration, loss of consciousness, cardiac arrest are the causes of increased preoperative mortality. Short duration of
aortic cross-clamping, minimizing intraoperative blood loss, protecting patients from low blood pressure during the operation and good
diuresis increase the survival rate.

References

  • 1. Booher AM, Eagle KA. Diagnosis and management issues in thoracic aortic aneurysm. American Heart Journal, 2011;162(1):38-46.
  • 2. Aggarwal S, Qamar A, Sharma V, Sharma A. Abdominal aortic aneurysm: A comprehensive review. Experimental & Clinical Cardiology, 2011;16(1):11.
  • 3. Sidloff DA, Saratzis A, Thompson J, Katsogridakis E, Bown MJ. Infra-renal aortic diameter and cardiovascular risk: Making better use of abdominal aortic aneurysm screening outcomes. Journal of Vascular Surgery, 2021;74(2):679-680.
  • 4. Guo DC, Papke CL, He R, Milewicz DM. Pathogenesis of thoracic and abdominal aortic aneurysms. Annals of the New York Academy of Sciences, 2006;1085(1):339-352.
  • 5. Song Q, Guo Y, Huo Z, Wang M, Sun X, Zhou Z, Wu X. Analysis of high-risk factors and mortality prediction of ruptured abdominal aortic aneurysm. Annals of Vascular Surgery, 2024;109:91- 100.
  • 6. Haller SJ, Azarbal AF, Rugonyi S. Predictors of abdominal aortic aneurysm risks. Bioengineering, 2020;7(3):79.
  • 7. Castro-Ferreira R, Vidoedo J, Peixoto J, Canedo A, Teixeira J, Leite-Moreira A, Sampaio S. Incidental abdominal aortic aneurysms are largely undocumented and unmonitored. Annals of Vascular Surgery, 2021;77:182-186.
  • 8. Rezaeitaleshmahalleh M, Sunderland KW, Lyu Z, Johnson T, King K, Liedl DA, Jiang J. Computerized differentiation of growth status for abdominal aortic aneurysms: A feasibility study. Journal of Cardiovascular Translational Research, 2023;16(4):874-885.
  • 9. Cherian AM, Venu R, Raja PI, Saravanan S, Khan U, Kantawala R, Sharma A. Outcomes of endovascular aneurysm repair (EVAR) compared to open repair in abdominal aortic aneurysm: An umbrella meta-analysis. Cureus, 2024;16(6).
  • 10. Steyerberg EW, Kievit J, Van Otterloo JADM, van Bockel JH, Eijkemans MJ, Habbema JDF. Perioperative mortality of elective abdominal aortic aneurysm surgery: A clinical prediction rule based on literature and individual patient data. Archives of Internal Medicine, 1995;155(18):1998-2004.
  • 11. Sharma A, Sethi P, Gupta K. Endovascular abdominal aortic aneurysm repair. Interventional Cardiology Clinics, 2020;9(2):153-168.
  • 12. Smidfelt K, Nordanstig J, Davidsson A, Törngren K, Langenskiöld M. Misdiagnosis of ruptured abdominal aortic aneurysms is common and is associated with increased mortality. Journal of Vascular Surgery, 2021;73(2):476-483.
  • 13. Fattahi N, Rosenblad A, Kragsterman B, Hultgren R. Risk factors in 50-year-old men predicting development of abdominal aortic aneurysm. Journal of Vascular Surgery, 2020;72(4):1337- 1346.
  • 14. Urbonavicius S, Urbonaviciene G, Honoré B, Henneberg EW, Vorum H, Lindholt JS. Potential circulating biomarkers for abdominal aortic aneurysm expansion and rupture: A systematic review. European Journal of Vascular and Endovascular Surgery, 2008;36(3):273-280.
  • 15. Ernst CB. Abdominal aortic aneurysm. New England Journal of Medicine, 1993;328(16):1167-1172.
  • 16. Blakemore AH, Voorhees AB Jr. Aneurysm of the aorta: A review of 365 cases. Angiology, 1954;5(3):209-231.
  • 17. Summers KL, Kerut EK, Sheahan CM, Sheahan MG III. Evaluating the prevalence of abdominal aortic aneurysms in the United States through a national screening database. Journal of Vascular Surgery, 2021;73(1):61-68.
  • 18. Talvitie, M. Abdominal Aortic Aneurysms: Sex and Gender Disparities in Surveillance, Treatment and Outcome. Karolinska Institutet (Sweden). 2023
  • 19. Aggarwal S, Qamar A, Sharma V, Sharma A. Abdominal aortic aneurysm: A comprehensive review. Experimental & Clinical Cardiology, 2011;16(1):11.
  • 20. Brown LC, Powell JT. Risk factors for aneurysm rupture in patients kept under ultrasound surveillance. UK Small Aneurysm Trial Participants. Annals of Surgery, 1999;230(3):289-296.
  • 21. Chun KC, Dolan KJ, Smothers HC, Irwin ZT, Anderson RC, Gonzalves AL, Lee ES. The 10-year outcomes of a regional abdominal aortic aneurysm screening program. J Vasc Surg. 2019 Oct;70(4):1123-1129.
  • 22. Pál D, Szilágyi B, Berczeli M, Szalay CI, Sárdy B, Oláh Z, Sótonyi P. Ruptured aortic aneurysm and dissection related death: An autopsy database analysis. Pathology & Oncology Research, 2020;26:2391-2399.
  • 23. Smidfelt K, Nordanstig J, Davidsson A, Törngren K, Langenskiöld M. Misdiagnosis of ruptured abdominal aortic aneurysms is common and is associated with increased mortality. Journal of Vascular Surgery, 2021;73(2):476-483.
  • 24. Haveman JW, Zeebregts CJ, Verhoeven EL, van den Berg P, van den Dungen JJ, Zwaveling JH, Nijsten MW. Changes in laboratory values and their relationship with time after rupture of an abdominal aortic aneurysm. Surgery Today, 2008;38:1091- 1101.
  • 25. Tang Y, Chen J, Huang K, Luo D, Liang P, Feng M, Xu A. The incidence, risk factors and in-hospital mortality of acute kidney injury in patients after abdominal aortic aneurysm repair surgery. BMC Nephrology, 2017;18:1-8.
  • 26. Kim SD, Hwang JK, Park SC, Kim JI, Moon IS, Park JS, Yun SS. Predictors of postoperative mortality of ruptured abdominal aortic aneurysm: a retrospective clinical study. Yonsei Med J. 2012 Jul 1;53(4):772-80.
  • 27. Rutledge R, Oller DW, Meyer AA, Johnson GJ Jr. A statewide, population-based time-series analysis of the outcome of ruptured abdominal aortic aneurysm. Ann Surg 1996;223:492-502.
  • 28. Howard DPJ, Banerjee A, Fairhead JF, Handa A, Silver LE, Rothwell PM. Age-specific incidence, risk factors and outcome of acute abdominal aortic aneurysms in a defined population. British Journal of Surgery, 2015;102(8):907-915.
  • 29. Cho MJ, Yoon HJ, Park JY, Huh S, Kim YW. The risk factors influencing postoperative mortality in the patients with ruptured abdominal aortic aneurysm. J Korean Soc Vasc Surg 2004;20:208-13.
  • 30. Roberts K, Revell M, Youssef H, Bradbury AW, Adam DJ. Hypotensive resuscitation in patients with ruptured abdominal aortic aneurysm. Eur J Vasc Endovasc Surg 2006;31:339-44
There are 30 citations in total.

Details

Primary Language Turkish
Subjects Cardiovascular Surgery
Journal Section Research Article
Authors

Ali Kemal Gür 0000-0002-6460-4941

Oğuz Arslantürk 0000-0002-4047-9656

Publication Date December 30, 2024
Submission Date November 13, 2024
Acceptance Date December 18, 2024
Published in Issue Year 2024 Volume: 8 Issue: 3

Cite

Vancouver Gür AK, Arslantürk O. Rüptüre Abdominal Aort Anevrizmasında Zamanla Yarış: Hayatta Kalma ve Tedavi Sonuçlarının Retrospektif Analizi. Med J West Black Sea. 2024;8(3):355-62.

Medical Journal of Western Black Sea is a scientific publication of Zonguldak Bulent Ecevit University Faculty of Medicine.

This is a refereed journal, which aims at achieving free knowledge to the national and international organizations and individuals related to medical sciences in publishedand electronic forms.

This journal is published three annually in April, August and December.
The publication language of the journal is Turkish and English.