BACLOFEN USAGE FOR SUICIDE AND øNTOXICATION: CASE REPORT

Abstract

Baclofen is a lipophilic analogue of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in central nervous system. Baclofen toxicity can be a cause of profound coma with brainstem dysfunction mimicking brain death. Measuring plasma levels is not always possible and may be misleading. It’s important to be careful in clinical evaluation and provide full supportive care. Treatment of patients with acute baclofen intoxication should take place in hospitals appropriately equipped which can provide artificial respiration. However, as demonstrated in our case, the prognosis can be good even in severe cases.

Keywords

• Baclofen
• coma
• GABA analogue
• intoxication

İNTİHAR AMAÇLI KULLANILAN BAKLOFEN VE ENTOKSİKASYONU: OLGU SUNUMU

Abstract

Baklofen, merkezi sinir sisteminde bir inhibitör transmitter olan, lipofilik GABA (gamma-aminobutirik asit) analoğudur. Yüksek doz baklofen alımı, beyin ölümünü taklit eden derin koma tablosuna neden olabilir. İlacın plazma düzeylerinin belirlenmesi her zaman mümkün olamayacağı gibi tanı konulmasını da güçleştirebilir. Klinik değerlendirme ve destekleyici tedavilerin önemi büyüktür. Baklofen ile akut zehirlenen hastaların tedavisinde tam donanımlı hastanelerde solunum desteği gerektiğinde verilebilmelidir. Bununla birlikte, olgumuzda da görüldüğü gibi ciddi vakalarda bile prognoz iyi seyreder.

Keywords

• Baklofen
• koma
• GABA analogu
• entoksikasyon

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