A Case of Iatrogenic Wernicke Encephalopathy Following Prolonged Total Parenteral Nutrition

Abstract

Thiamine is a water-soluble vitamin that plays a role in the metabolism of glucose. Thiamine deficiency affects cardiovascular and nervous systems. Wernicke encephalopathy is characterized by oculomotor abnormalities, ataxia and cognitive deterioration caused by thiamine deficiency. It is most commonly observed in chronic alcoholics. It may also occur in patients who receive long-term total parenteral nutrition. In this study, we present the case of a 50-year-old male patient who underwent surgery for laryngeal cancer, who stayed in the intensive care unit for a prolonged period and received total parenteral nutrition because of the inability of oral intake.

Keywords

• Wernicke encephalopathy,total parenteral nutrition,thiamine deficiency

Uzamış Total Parenteral Nütrisyon Sonrası Gelişen İyatrojenik Wernicke Ensefalopatisi Olgusu

Abstract

Tiamin (Vitamin B1) glikoz metabolizmasında rol alan suda çözünen bir vitamindir. Eksikliğinde kardiyovasküler sistem ve sinir sistemi etkilenir. Wernicke ensefalopatisi, klinik olarak okulomotor anormallikler, ataksi ve mental durum değişikleri ile karekterize tiamin eksikliğinden kaynaklanan bir ensefalopati tablosudur. En sık olarak kronik alkol bağımlılarında görülmektedir. Uzun süre total parenteral nütrisyon desteği alan hastalarda da gelişebilmektedir. Yazımızda larenks kanseri nedeniyle opere olan, uzun süre yoğun bakımda kalan, oral beslenememesi nedeniyle total parenteral nütrisyon desteği alan ve Wernicke ensefalopatisi tanısı konularak nöroloji yoğun bakıma alınan 50 yaşında erkek hasta sunulmuştur.

Keywords

• Wernicke ensefalopatisi,total paranteral nutrisyon,tiamin eksikliği

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