Karpal Tünel Sendromunda İnflamasyonun Nötrofil-Lenfosit Oranı, Platelet-Lenfosit Oranı ve Ortalama Platelet Hacmi ile Değerlendirilmesi

Abstract

Amaç: Karpal tünel sendromu median sinirin karpal tünel seviyesinde sıkışmasından kaynaklanan ve en yaygın görülen mononöropati şeklidir. Büyük bir kısmı idiopatik olan bu tablonun fizyopatolojik mekanizması halen tam açıklanamamıştır. Biz bu çalışmada karpal tünel sendromun’da sistemik inflamasyonun olası rolünü nötrofil-lenfosit oranı, platelet-lenfosit oranı ve ortalama platelet hacmi değerleri ile incelemeyi amaçladık. Gereç ve Yöntemler: Çalışmaya yaşları 20 ve 60 arasında değişen, elektofizyoloji labaratuvarımıza refere edilen ve American Academy of Neurology kriterlerine göre karpal tünel sendromu tanısı konulan toplam 55 hasta ve sağlıklı 36 kişi dahil edildi. Hastalar elektrofizyolojik bulgulara göre hafif, orta ve şiddetli olmak üzere üç alt gruba ayrıldı. Hastaların klinik açıdan fonksiyonel durumları ve hastalık şiddetleri Boston Questionnaire ile değerlendirildi. Bulgular: Çalışmaya 71 kadın (%78,02) ve 20 erkek (%21,98) olmak üzere toplam 91 kişi alınmıştır. Hasta grubu yaş ortalaması 50,04±9,78 olan 43 kadın ve 12 erkekten oluşmaktadır. Kontrol grubu yaş ortalaması 49,92 ±7,59 olan 28 kadın ve 8 erkekten oluşmaktadır. Hasta ve kontrol grupları arasında karşılaştırıldığında nötrofil-lenfosit oranı, platelet-lenfosit oranı ve ortalama platelet hacmi değerleri arasında anlamlı fark saptanmadı. Ölçülen değerler hasta alt gruplarında karşılaştırıldığında hastalık şiddetiyle değerler arasında anlamlı fark saptanmamıştır. Sonuç: Karpal tünel sendromu fizyopatolojisinde sistemik inflamasyonun rolünün belirsiz olduğu, bazı mekanik ve lokal patolojilerin etyopatogenezi aydınlatmakta daha ön planda düşünülmesi gerektiği akla yatkın görünmektedir. Konu ile ilgili hasta sayısının artırıldığı çok merkezli ve uzunlamasına çalışmalara ihtiyaç olduğu kanaatindeyiz.

Keywords

• Karpal tünel sendromu
• median sinir
• inflamasyon
• mononöropati

Evaluation of Inflammation in the Carpal Tunnel Syndrome by the Neutrophil-Lymphocyte Rate, Platelet- Lymphocyte Rate and Mena Platelet Volume

Abstract

Objective: Carpal tunnel syndrome is the most common form of mononeuropathy caused by compression of the median nerve at the carpal tunnel level. The physiopathological mechanism of this picture, which is mostly idiopathic, is still not fully explained. In this study, we aimed to examine the possible role of inflammation in carpal tunnel syndrome with neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and mean platelet volume values. Materials and Methods: A total of 55 patients, aged between 20 and 60 years, referred to our electrophysiology laboratory and diagnosed with carpal tunnel syndrome according to the American Academy of Neurology criteria and 36 healthy participants were included in the study. Patients were divided into three subgroups as mild, moderate and severe according to electrophysiological findings. Clinical functional status and disease severity of patients were evaluated with Boston Questionnaire. Results: A total of 91 people, 71 women (78.02%) and 20 men (21.98%), were included in the study. The patient group consists of 43 women and 12 men, with an average age of 50.04 ± 9.78. The control group consists of 28 women and 8 men with an average age of 49.92 ± 7.59. When compared between patient and control groups, no significant difference was found between neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and mean platelet volüme values. When the measured values were compared in the patient subgroups, there was no significant difference between disease severity and values. Conclusions: The role of systemic inflammation in carpal tunnel syndrome physiopathology is uncertain, it seems plausible that some mechanical and local pathologies should be considered in the foreground to elucidate the etiopathogenesis. We believe that high number of patients, multicenter and longitudinal studies are needed.

Keywords

• Carpal tunnel syndrome
• median nevre
• inflammation
• mononeuropathy

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