Testicular Seminomatous and Nonseminomatous Germ Cell Tumors: Clinical and Pathological Features

Abstract

Objective: In the present study, it was aimed to investigate the differences between the clinical and histopathological features of testicular seminomatous and non-seminomatous germ cell tumors diagnosed in our center in the recent 10 years. Methods: All the patients in whom diagnosis of testicular germ cell tumor was histologically confirmed in our center between January 2010 and May 2020 were involved in the study. The medical records of the patients were screened and Hematoxylin-Eosin (H+E) stained slides of the patients were re-evaluated. The tumor classification and primary tumor stage determination (pT) were carried out in accordance with the 2016 WHO Classification of Tumors of the Urinary System and Male Genital Organs. Results:The morphology of seminoma (SEM) and non-seminomatous germ cell tumors (NSE-GCTs) were identified in 27 (51%) and 26 (49%) of the study patients, respectively. In the SEM group, patient ages ranged between 23-55 years (min-max) and median age was 33 years (IQR=26.0-41.0) while those values for the NSE-GCT cases were 16-44 years and 28 years (IQR=22.75-29.5), respectively. The evaluation of the pTs without subgroup discrimination demonstrated that 21 (39.6%), 31 (58.5%) and 1 (1.9%) of the tumors were Stage 1, Stage 2 and Stage 3, respectively. Conclusion: Testicular cancers are the most frequently seen malignancy in the young males and its incidence has increased in the recent years. The complete cure rate is approximately 100% thanks to early diagnosis as well as high chemosensitivity and radiosensitivity of these tumors.

Keywords

• Testicular Cancer
• Germ Cell Tumor
• Seminoma
• Non-Seminomatous Germ Cell Tumor

Testiküler Seminomatöz ve Nonseminomatöz Germ Hücreli Tümörler: Klinik ve Patolojik Özelliklerinin Karşılaştırılması

Abstract

Amaç: Bu çalışmada merkezimizde son 10 yılda tanı alan testiküler seminomatöz ve non-seminomatöz germ hücreli tümörlerin klinik ve histopatolojik özelliklerinin farklarını araştırmayı amaçladık. Gereç ve Yöntem: Ocak 2010’dan Mayıs 2020’ye kadar merkezimizde histopatolojik olarak kanıtlanmış testiküler germ hücreli tümör tanısı olan tüm hastalar çalışma kapsamına alındı. Medikal kayıtlar taranarak hastalara ait Hematoksilen-Eozin (H+E) boyalı preparatlar yeniden değerlendirildi. Tümörlerin sınıflandırılmasında ve primer tümörün evresinin belirlenmesinde (pTs) 2016 Dünya Sağlık Örgütü Üriner Sistem ve Erkek Genital Organları Tümörleri Sınıflaması esas alındı. Bulgular: Çalışmamıza dâhil olan olguların 27 tanesi (%51) SEM, 26 tanesi (%49) ise NSE-GHT morfolojisinde idi. SEM grubunda hastaların yaş aralığı 23-55 yıl (minimum-maksimum) arasında değişmekte olup ortanca yaş 33 yıl (IQR=26.0-41.0 yıl) iken NSE-GHT’ler için bu değerler sırasıyla 16-44 yıl ve 28 yıl (IQR=22.75-29.5 yıl) idi. Alt grup ayrımı yapılmaksızın pTs değerlendirmesine göre 21 tümör (%39.6) Evre 1, 31 tümör (%58.5) Evre 2 ve 1 tümör (%1.9) Evre 3 idi. Sonuç: Testis kanserleri genç erkeklerde en sık görülen malignite olup son yıllarda insidansı artış göstermiştir. Komplet kür oranı, erken tanı ve bu tümörlerin yüksek düzeyde kemo- ve radyosensitif olmasından dolayı %100’e yakındır.

Keywords

• Testis Kanseri
• Germ Hücreli Tümör
• Seminom
• Non-Seminomatöz Germ Hücreli Tümör

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