Relationship Between Diabetic Peripheral Neuropathy and Vitamin D

Abstract

Objective: We aimed to compare electrophysiologically supported and unsupported diabetic peripheral neuropathy (DPN) patients in terms of vitamin D levels within themselves and with the control group.Methods: Patients who applied to Hatay State Hospital Physical Medicine and Rehabilitation Outpatient Clinic and were diagnosed with DPN were divided into two groups according to whether or not pathological findings were detected electrophysiologically. Patients of similar age and gender, who applied to the outpatient clinic with complaints of muscle pain, formed the control group and the groups were compared in terms of vitamin D levels. DPN subgroups were also compared in terms of HbA1c levels and duration of diabetes.Results: No statistically significant difference was found between the DPN groups and the control group in terms of age and gender. Vitamin D levels were found to be significantly higher in the control group compared to the electrophysiologically supported DPN group. When DPN subgroups were compared within themselves, diabetes duration and HbA1c levels were found to be statistically significantly higher in the electrophysiologically supported DPN group.Conclusion: Low vitamin D levels can accelerate the development of neuropathy in diabetic patients and worsen the clinical picture of patients.

Keywords

• Vitamin D
• Electromyography
• Diabetic Peripheral Neuropathy

Diyabetik Periferik Nöropati ve Vitamin D İlişkisi

Abstract

Amaç: Elektrofizyolojik olarak desteklenen ve desteklenmeyen diyabetik periferik nöropati (DPN) hastalarının, kendi içerisinde ve kontrol grubu ile D vitamini düzeyleri açısından karşılaştırması amaçlanmıştır.Yöntem: Hatay Devlet Hastanesi Fiziksel Tıp ve Rehabilitasyon Polikliniğine başvurmuş ve DPN tanısı almış hastalar elektrofizyolojik olarak patolojik bulgu saptanıp, saptanmamalarına göre iki gruba ayrıldı. Benzer yaş ve cinsiyette, kas ağrısı şikâyeti ile poliklinik başvurusu olan hastalar da kontrol grubunu oluşturdu ve gruplar D vitamini düzeyleri açısından karşılaştırıldı. DPN alt grupları da kendi içerisinde HbA1c seviyeleri ve diyabet süreleri açısından kıyaslandı.Bulgular: DPN grupları ve kontrol grubu arasında yaş ve cinsiyet açısından istatistiksel olarak anlamlı farklılık saptanmadı. Vitamin D düzeyleri, elektrofizyolojik olarak desteklenen DPN grubuna kıyasla, kontrol grubunda anlamlı derecede daha yüksek bulunmuştur. DPN alt grupları kendi içerisinde karşılaştırıldığında elektrofizyolojik olarak desteklenen DPN grubunda, diyabet süresi ve HbA1c düzeyleri istatistiksel olarak anlamlı olacak şekilde daha yüksek bulunmuştur.Sonuç: Düşük D vitamini seviyeleri diyabetik hastalarda nöropati gelişimini hızlandırabilir ve hastaların klinik durumlarını kötüleştirebilir.

Keywords

• Diyabetik periferik nöropati
• D vitamini
• Elektromiyografi

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