The Effect of Familial Mediterranean Fever Disease on The Cornea

Abstract

Objective: To investigate corneal structural in patients with Familial Mediterranean Fever (FMF). Methods: This case-control study included 64 patients with FMF and, 49 age and gender similar healthy subjects without any eye disease. Endothelial cell density (ECD), the coefficient of variation in cell size (CV) and percentage of hexagonality were measured by non-contact specular microscopy, central corneal thickness (CCT) was measured by ultrasonic pachymetry. Results: The mean CCT value was 516.89± 32.23 μm in the study group and 545.12±24.56 μm in the control group. The mean ECD, CV, and percentage of hexagonality values were 3402.51±383.84 cells/mm², 26.72±4.55%, and 68.60±8.63%in the study group, respectively and 3339.46±322.60 cells/mm², 27.59± 5.23%, and 67.34± 9.38% in the control group, respectively. Of these parameters, the CCT values were statistically significantly different between the study and control groups (p = 0.011). Conclusion: Compared to healthy individuals, patients with FMF may have significant morphological changes in the structure of the cornea.

Keywords

• Familial Mediterranean Fever
• Cornea
• İnflammation
• Central Corneal Thickness
• Corneal Endothelium

Ailevi Akdeniz Ateşinin Korneaya Etkisi

Abstract

Amaç:Ailevi Akdeniz Ateşi (AAA) hastalarında korneal yapısal değişiklikleri araştırmak. Gereç ve Yöntem: Çalışmaya AAA hastası olan 64 kişi (çalışma grubu) ile herhangibir göz hastalığı olmayan, yaş ve cinsiyet uyumlu 49 kişi kontrol grubu olarak alındı. Santral kornea kalınlığı, endotel hücre sayısı (EHS), hücrelerin hegzagonalite yüzdesi(HEXA) ve varyasyon katsayısı (VK) ultrasonik pakimetre ile değerlendirildi. Bulgular: Çalışma grubunda, ortalama santral kornea kalınlığı(SKK) 516.89± 32.23 iken kontrol grubunda 545.12±24.56 olarak bulundu. Endotel hücre sayısı(EHS), hegzagonalite yüzdesi(HEXA) ve hücre varyasyon katsayısı(VK) sırasıyla 3402.51±383.84 cells/mm², 26.72±4.55%, and 68.60±8.63 % idi. Kontrol grubunda ise aynı parametreler 3339.46±322.60 cells/mm², 27.59± 5.23%, ve 67.34± 9.38% olarak bulundu. Bu parametrelerden santral kornea kalınlığı(CCT) ise iki grup arasında istatiksel olarak anlamlı farklı bulundu(p=0.011). Sonuç: Çalışma sonuçlarına göre AAA hastalarında, sağlıklı bireyler ile karşılaştırıldığında önemli korneal morfolojik-yapısal değişiklikler olabilir.

Keywords

• Ailevi Akdeniz Ateşi
• Kornea
• İnflamasyon
• Santral Korneal Kalınlık
• Korneal Endotel

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