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KALP BİR POMPADAN ÖTE BİR ŞEY OLAMAZ MI?

Year 2010, Volume: 1 Issue: 1, 31 - 34, 03.03.2015

Abstract

Kalp nakillerinden sonra meydana gelen kişilik değişiklikleri, kalp ve beyin arasındaki karşılıklı iletişim, REM (rapid eye movement) uykusu sırasında kardiyovasküler düzenlemede amigdalanın rolü, yine REM uykusunun gelişmekte olan beyinde nöron gelişimi ve hafıza konsolidasyonu üzerindeki etkileri, atriyal ve beyin natriüretik peptitlerin çeşitli etkileri ve kardiyak nöral krista hücrelerinin kalp gelişimindeki rollerine dayanarak bu çalışmada kalbin ve özellikle SA (sinoatriyal) düğümün emosyonel hafıza işleme ve saklamada etkin olabileceği hipotezini öne sürdüm. Bunun da ötesinde SA düğümüne yapılacak çeşitli müdahelelerin, altında istenmeyen anıların ve yaşam deneyimlerinin yattığı düşünülen bazı psikiyatrik hastalıklarda tedavi amaçlı olarak kullanılabileceği önerisi de tartışıldı.

References

  • 1. Armour A AJ: Neurocardiology. New York, Oxford University Press, 1994.
  • 2. Aggleton J: The functional effects of amygdala lesions in humans: a comparison with findings from monkeys. New-York, Wiley-Liss, 1992.
  • 3. Bechara A, Tranel D, Damasio H, Adolphs R, Rockland C, Damasio AR: Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. Science 1995; 269: 1115-1118.
  • 4. Adolphs R, Tranel D, Damasio H, Damasio A: Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala. Nature 1994; 372: 669-672.
  • 5. Cahill L: Modulation of long-term memory storage in humans by emotional arousal:adrenergic activation and the amygdala. New-York, Oxford University Press, 2000.
  • 6. Ashby FG, Isen AM, Turken AU: A neuropsychological theory of positive affect and its influence on cognition. Psychol Rev 1999; 106: 529-550.
  • 7. Desseilles M, Vu TD, Laureys S, Peigneux P, Degueldre C, Phillips C, Maquet P: A prominent role for amygdaloid complexes in the Variability in Heart Rate (VHR) during Rapid Eye Movement (REM) sleep relative to wakefulness. Neuroimage 2006; 32: 1008-1015.
  • 8. Maquet P, Peters J, Aerts J, Delfiore G, Degueldre C, Luxen A, Franck G: Functional neuroanatomy of human rapid-eye-movement sleep and dreaming. Nature 1996; 383: 163-166.
  • 9. Mirmiran M, Uylings HB, Corner MA: Pharmacological suppression of REM sleep prior to weaning counteracts the effectiveness of subsequent environmental enrichment on cortical growth in rats. Brain Res 1983; 283: 102-105.
  • 10. Stickgold R: EMDR: a putative neurobiological mechanism of action. J Clin Psychol 2002; 58: 61-75.
  • 11. Gorza L, Schiaffino S, Vitadello M: Heart conduction system: a neural crest derivative? Brain Res 1988; 457: 360-366.
  • 12. El Sharaby AA, Egerbacher M, Hammoda AK, Bock P: Immunohistochemical demonstration of Leu-7 (HNK-1), Neurone-specific Enolase (NSE) and Protein-Gene Peptide (PGP) 9.5 in the developing camel (Camelus dromedarius) heart. Anat Histol Embryol 2001; 30: 321-325.
  • 13. Verberne ME, Gittenberger-De Groot AC, Poelmann RE: Distribution of antigen epitopes shared by nerves and the myocardium of the embryonic chick heart using different neuronal markers. Anat Rec 2000; 260: 335-350.
  • 14. Waldo K, Zdanowicz M, Burch J, Kumiski DH, Stadt HA, Godt RE, Creazzo TL, Kirby ML: A novel role for cardiac neural crest in heart development. J Clin Invest 1999; 103: 1499-1507.
  • 15. de Bold AJ: Atrial natriuretic factor: a hormone produced by the heart. Science 1985; 230: 767-770.
  • 16. Yasue H, Yoshimura M, Sumida H, Kikuta K, Kugiyama K, Jougasaki M, Ogawa H, Okumura K, Mukoyama M, Nakao K: Localization and mechanism of secretion of B-type natriuretic peptide in comparison with those of A-type natriuretic peptide in normal subjects and patients with heart failure. Circulation 1994; 90: 195-203.
  • 17. Bidzseranova A, Gueron J, Balaspiri L, Telegdy G: Intracerebroventricularly administered atrial natriuretric peptide (ANP) antiserum attenuates fear-motivated learning behavior in rats. Peptides 1992; 13: 957-960.
  • 18. Bidzseranova A, Gueron J, Penke B, Telegdy G: The effects of atrial natriuretic peptide on active avoidance behavior in rats. The role of transmitters. Pharmacol Biochem Behav 1991; 40: 61-64.
  • 19. Bidzseranova A, Gueron J, Toth G, Penke B, Telegdy G: Effect of atrial natriuretic peptide on apomorphine-induced stereotyped cage-climbing behavior in mice. Eur J Pharmacol 1992; 211: 411-414.
  • 20. Bidzseranova A, Gueron J, Toth G, Penke B, Telegdy G: Effect of atrial natriuretic peptide on dopa potentiation in mice. Brain Res Bull 1992; 28: 767-768.
  • 21. Bidzseranova A, Gueron J, Toth G, Penke B, Varga J, Telegdy G: Behavioral effects of atrial and brain natriuretic peptides in rats. Neuroreport 1992; 3: 283-285.
  • 22. Bidzseranova A, Gueron J, Toth G, Varga J, Telegdy G: Structure-activity studies on the effects of atrial natriuretic peptide, brain natriuretic peptide and their analogs on fear-motivated learning behavior in rats. Neuropeptides 1992; 23: 61-65.
  • 23. Bidzseranova A, Toth G, Telegdy G: The effects of atrial natriuretic peptide on the open-field activity of rats. The role of neurotransmitters. Neuropeptides 1991; 20: 163-167.
  • 24. Telegdy G, Bidzseranova A, Kovacs A, Gabos L: Antiamnesic properties of some neuropeptides and the involvement of neurotransmitters in the rats. Patol Fiziol Eksp Ter 1992:75-77.
  • 25. Kellner M, Wiedemann K, Holsboer F: Atrial natriuretic factor inhibits the CRH-stimulated secretion of ACTH and cortisol in man. Life Sci 1992; 50: 1835-1842.
  • 26. Strohle A, Kellner M, Holsboer F, Wiedemann K: Anxiolytic activity of atrial natriuretic peptide in patients with panic disorder. Am J Psychiatry 2001; 158: 1514-1516.
  • 27. Cardinal RN, Parkinson JA, Hall J, Everitt BJ: Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neurosci Biobehav Rev 2002; 26: 321-352.
  • 28. McCraty R, Atkinson M, Tiller WA, Rein G, Watkins AD: The effects of emotions on short-term power spectrum analysis of heart rate variability. Am J Cardiol 1995; 76: 1089-1093.
  • 29. Yeragani VK, Pohl R, Berger R, Balon R, Ramesh C, Glitz D, Srinivasan K, Weinberg P: Decreased heart rate variability in panic disorder patients: a study of power-spectral analysis of heart rate. Psychiatry Res 1993; 46: 89-103.
  • 30. Yeragani VK, Pohl R, Balon R, Ramesh C, Glitz D, Jung I, Sherwood P: Heart rate variability in patients with major depression. Psychiatry Res 1991; 37: 35-46.
  • 31. Yeragani VK, Pohl R, Balon R, Jung I, Kareus R: Heart rate in panic disorder. Acta Psychiatr Scand 1991; 83: 79.
  • 32. Pearsall P, Schwartz GE, Russek LG: Changes in heart transplant recipients that parallel the personalities of their donors. Integr Med 2000; 2: 65-72.
  • 33. Pearsall PK: Are heart transplant recipients receiving cellular memories from their donated organ? A heuristic study. Hawaii Med J 2001; 60: 282, 300

COULDN’T HEART BE MORE THAN A PUMP?

Year 2010, Volume: 1 Issue: 1, 31 - 34, 03.03.2015

Abstract

Based on the 1) personality changes observed following heart transplantations; 2) the two-way, dynamic, ongoing dialog between the brain and the heart and its reflection as alterations in heart rate variability; 3) the prominent role of amygdala in cardiovascular regulation during rapid eye movement sleep and 4) the importance of rapid eye movement sleep in the developing brain to establish proper neuronal circuits and its memory consolidation effect; 5) the role of cardiac neural crest cells in heart development and 6) the effects of Atrial and Brain Natriuretic Peptides; I hypothesize that the heart, particularly the SA node, could function in emotional memory processing and storage in collaboration with related brain regions. Moreover, intervention to SA node in certain psychiatric diseases with underlying unwanted memories and life experiences could be a novel choice of therapy. 

References

  • 1. Armour A AJ: Neurocardiology. New York, Oxford University Press, 1994.
  • 2. Aggleton J: The functional effects of amygdala lesions in humans: a comparison with findings from monkeys. New-York, Wiley-Liss, 1992.
  • 3. Bechara A, Tranel D, Damasio H, Adolphs R, Rockland C, Damasio AR: Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. Science 1995; 269: 1115-1118.
  • 4. Adolphs R, Tranel D, Damasio H, Damasio A: Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala. Nature 1994; 372: 669-672.
  • 5. Cahill L: Modulation of long-term memory storage in humans by emotional arousal:adrenergic activation and the amygdala. New-York, Oxford University Press, 2000.
  • 6. Ashby FG, Isen AM, Turken AU: A neuropsychological theory of positive affect and its influence on cognition. Psychol Rev 1999; 106: 529-550.
  • 7. Desseilles M, Vu TD, Laureys S, Peigneux P, Degueldre C, Phillips C, Maquet P: A prominent role for amygdaloid complexes in the Variability in Heart Rate (VHR) during Rapid Eye Movement (REM) sleep relative to wakefulness. Neuroimage 2006; 32: 1008-1015.
  • 8. Maquet P, Peters J, Aerts J, Delfiore G, Degueldre C, Luxen A, Franck G: Functional neuroanatomy of human rapid-eye-movement sleep and dreaming. Nature 1996; 383: 163-166.
  • 9. Mirmiran M, Uylings HB, Corner MA: Pharmacological suppression of REM sleep prior to weaning counteracts the effectiveness of subsequent environmental enrichment on cortical growth in rats. Brain Res 1983; 283: 102-105.
  • 10. Stickgold R: EMDR: a putative neurobiological mechanism of action. J Clin Psychol 2002; 58: 61-75.
  • 11. Gorza L, Schiaffino S, Vitadello M: Heart conduction system: a neural crest derivative? Brain Res 1988; 457: 360-366.
  • 12. El Sharaby AA, Egerbacher M, Hammoda AK, Bock P: Immunohistochemical demonstration of Leu-7 (HNK-1), Neurone-specific Enolase (NSE) and Protein-Gene Peptide (PGP) 9.5 in the developing camel (Camelus dromedarius) heart. Anat Histol Embryol 2001; 30: 321-325.
  • 13. Verberne ME, Gittenberger-De Groot AC, Poelmann RE: Distribution of antigen epitopes shared by nerves and the myocardium of the embryonic chick heart using different neuronal markers. Anat Rec 2000; 260: 335-350.
  • 14. Waldo K, Zdanowicz M, Burch J, Kumiski DH, Stadt HA, Godt RE, Creazzo TL, Kirby ML: A novel role for cardiac neural crest in heart development. J Clin Invest 1999; 103: 1499-1507.
  • 15. de Bold AJ: Atrial natriuretic factor: a hormone produced by the heart. Science 1985; 230: 767-770.
  • 16. Yasue H, Yoshimura M, Sumida H, Kikuta K, Kugiyama K, Jougasaki M, Ogawa H, Okumura K, Mukoyama M, Nakao K: Localization and mechanism of secretion of B-type natriuretic peptide in comparison with those of A-type natriuretic peptide in normal subjects and patients with heart failure. Circulation 1994; 90: 195-203.
  • 17. Bidzseranova A, Gueron J, Balaspiri L, Telegdy G: Intracerebroventricularly administered atrial natriuretric peptide (ANP) antiserum attenuates fear-motivated learning behavior in rats. Peptides 1992; 13: 957-960.
  • 18. Bidzseranova A, Gueron J, Penke B, Telegdy G: The effects of atrial natriuretic peptide on active avoidance behavior in rats. The role of transmitters. Pharmacol Biochem Behav 1991; 40: 61-64.
  • 19. Bidzseranova A, Gueron J, Toth G, Penke B, Telegdy G: Effect of atrial natriuretic peptide on apomorphine-induced stereotyped cage-climbing behavior in mice. Eur J Pharmacol 1992; 211: 411-414.
  • 20. Bidzseranova A, Gueron J, Toth G, Penke B, Telegdy G: Effect of atrial natriuretic peptide on dopa potentiation in mice. Brain Res Bull 1992; 28: 767-768.
  • 21. Bidzseranova A, Gueron J, Toth G, Penke B, Varga J, Telegdy G: Behavioral effects of atrial and brain natriuretic peptides in rats. Neuroreport 1992; 3: 283-285.
  • 22. Bidzseranova A, Gueron J, Toth G, Varga J, Telegdy G: Structure-activity studies on the effects of atrial natriuretic peptide, brain natriuretic peptide and their analogs on fear-motivated learning behavior in rats. Neuropeptides 1992; 23: 61-65.
  • 23. Bidzseranova A, Toth G, Telegdy G: The effects of atrial natriuretic peptide on the open-field activity of rats. The role of neurotransmitters. Neuropeptides 1991; 20: 163-167.
  • 24. Telegdy G, Bidzseranova A, Kovacs A, Gabos L: Antiamnesic properties of some neuropeptides and the involvement of neurotransmitters in the rats. Patol Fiziol Eksp Ter 1992:75-77.
  • 25. Kellner M, Wiedemann K, Holsboer F: Atrial natriuretic factor inhibits the CRH-stimulated secretion of ACTH and cortisol in man. Life Sci 1992; 50: 1835-1842.
  • 26. Strohle A, Kellner M, Holsboer F, Wiedemann K: Anxiolytic activity of atrial natriuretic peptide in patients with panic disorder. Am J Psychiatry 2001; 158: 1514-1516.
  • 27. Cardinal RN, Parkinson JA, Hall J, Everitt BJ: Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neurosci Biobehav Rev 2002; 26: 321-352.
  • 28. McCraty R, Atkinson M, Tiller WA, Rein G, Watkins AD: The effects of emotions on short-term power spectrum analysis of heart rate variability. Am J Cardiol 1995; 76: 1089-1093.
  • 29. Yeragani VK, Pohl R, Berger R, Balon R, Ramesh C, Glitz D, Srinivasan K, Weinberg P: Decreased heart rate variability in panic disorder patients: a study of power-spectral analysis of heart rate. Psychiatry Res 1993; 46: 89-103.
  • 30. Yeragani VK, Pohl R, Balon R, Ramesh C, Glitz D, Jung I, Sherwood P: Heart rate variability in patients with major depression. Psychiatry Res 1991; 37: 35-46.
  • 31. Yeragani VK, Pohl R, Balon R, Jung I, Kareus R: Heart rate in panic disorder. Acta Psychiatr Scand 1991; 83: 79.
  • 32. Pearsall P, Schwartz GE, Russek LG: Changes in heart transplant recipients that parallel the personalities of their donors. Integr Med 2000; 2: 65-72.
  • 33. Pearsall PK: Are heart transplant recipients receiving cellular memories from their donated organ? A heuristic study. Hawaii Med J 2001; 60: 282, 300
There are 33 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Review
Authors

Ahmet Nacar This is me

Publication Date March 3, 2015
Submission Date March 2, 2015
Published in Issue Year 2010 Volume: 1 Issue: 1

Cite

Vancouver Nacar A. COULDN’T HEART BE MORE THAN A PUMP?. mkutfd. 2015;1(1):31-4.