Abstract
Fibronectin takes place in cell-cell interaction and is an important connective component of extracellular matrix. Fibronectin interacts with its receptor, β1 integrin, and takes place in cell adhesion, migration and proliferation. In this study, we examined the distribution of fibronectin and β1 integrin of testis tissues in different developmental stages in the light of literature.
As a result, we can conclude that fibronectin in testis is more functional in cell-basement membrane and basament membrane-interstitial tissue interaction than cell-cell interaction; and β1 integrin is essential in cell-cell interaction and spermatogenesis.
Keywords
References
- 1. Tanyolaç A. Özel Histoloji. Ankara: Yorum Basın Yayın Sanayi, 1999.
- 2. Brown E, Dejana E. Cell to cell contact and extracellular matrix editorial overview: Cell-cel and cell-matrix interactions – running, jumping, standing stil. Current Opinion in Cell Biology. 2003;15:505-8.
- 3. Giebel J, Löster K, Rune GM. Localization of integrin ȕ1, α1, α5 and α9 subunits in the rat testis. International Journal of Andrology. 1997;20:3-9.
- 4. Magnanti M, Gismondi A, Gandini O, Rossi FM, Michetti PM, Santtiemma V, Morrone S. Integrin pattern and effect on contraction in cultured testicular peritubular myoid cells. American Journal of Reproductive Immunology. 2001;45:21-7.
- 5. Shaller J, Glander, HJ, Dethloff J. Evidence of ȕ1 integrins and fibronectin on spermatogenic cells in human testis. Human Repropduction. 1993;8:1873-8.
- 6. Gartner PL, Hiatt JL. Color Text Book of Histology. Philadelphia: W.B. Saunders Company, 2001.
- 7. Junqueira LC, Carnıero J, Kelley RO. Temel Histoloji. Prof. Dr. Yener Aytekin, Doç. Dr. Seyhun SolakoğluÇeviren. 8. Baskı, İstanbul: Barış Kitabevi, 1998.
- 8. Erbengi T. Histoloji II. Ankara: Güneş Kitabevi, 1990.
- 9. Ross MH, Kaye GI, Pawlina, W. Histology, A Text and Atlas. Philadelphia: Williams & Wilkins, A Wolters Kluwer Company, 2003. 10. Skinner MK. Cell-Cell Interactions in the testis. Endocrine reviews. 1991;12: 45-77.
- 11. Garcia AJ, Boettiger D. Integrin- fibronectin interactions at the cell-material interface: initial integrin binding and signaling. Biomaterials. 1999;20: 2427-33.
Abstract
Hücreler arası etkileşime aracılık eden fibronektin, hücredışı matriksin önemli bir bağlayıcı bileşenidir. Fibronektin, reseptörü olan β1 integrinlerle etkileşerek hücre adhezyonu, hücre göçü ve çoğalması gibi yaşamsal olaylara katılırlar. Bu çalışmada çeşitli gelişim dönemlerindeki testis dokularında fibronektin ve laminin reseptörü olan β1 integrin dağılımı literatür ışığında değerlendirildi. Sonuç olarak testiste fibronektinin hücre-hücre etkileşiminden çok hücre-bazal membran ve bazal membran-interstisyel doku etkileşiminde işlevsel olduğu; β1 integrinin ise daha çok hücre-hücre etkileşiminde ve dolayısıyla spermatogeneziste etkin olabileceği kanısına varıldı.
Keywords
References
- 1. Tanyolaç A. Özel Histoloji. Ankara: Yorum Basın Yayın Sanayi, 1999.
- 2. Brown E, Dejana E. Cell to cell contact and extracellular matrix editorial overview: Cell-cel and cell-matrix interactions – running, jumping, standing stil. Current Opinion in Cell Biology. 2003;15:505-8.
- 3. Giebel J, Löster K, Rune GM. Localization of integrin ȕ1, α1, α5 and α9 subunits in the rat testis. International Journal of Andrology. 1997;20:3-9.
- 4. Magnanti M, Gismondi A, Gandini O, Rossi FM, Michetti PM, Santtiemma V, Morrone S. Integrin pattern and effect on contraction in cultured testicular peritubular myoid cells. American Journal of Reproductive Immunology. 2001;45:21-7.
- 5. Shaller J, Glander, HJ, Dethloff J. Evidence of ȕ1 integrins and fibronectin on spermatogenic cells in human testis. Human Repropduction. 1993;8:1873-8.
- 6. Gartner PL, Hiatt JL. Color Text Book of Histology. Philadelphia: W.B. Saunders Company, 2001.
- 7. Junqueira LC, Carnıero J, Kelley RO. Temel Histoloji. Prof. Dr. Yener Aytekin, Doç. Dr. Seyhun SolakoğluÇeviren. 8. Baskı, İstanbul: Barış Kitabevi, 1998.
- 8. Erbengi T. Histoloji II. Ankara: Güneş Kitabevi, 1990.
- 9. Ross MH, Kaye GI, Pawlina, W. Histology, A Text and Atlas. Philadelphia: Williams & Wilkins, A Wolters Kluwer Company, 2003. 10. Skinner MK. Cell-Cell Interactions in the testis. Endocrine reviews. 1991;12: 45-77.
- 11. Garcia AJ, Boettiger D. Integrin- fibronectin interactions at the cell-material interface: initial integrin binding and signaling. Biomaterials. 1999;20: 2427-33.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Review |
| Authors | |
| Publication Date | March 3, 2015 |
| Submission Date | March 2, 2015 |
| Published in Issue | Year 2010 Volume: 1 Issue: 2 |
