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The Effect Of Stereotactic Radiotherapy In Patients With Acoustic Neuroma

Year 2016, Volume: 7 Issue: 28, 25 - 30, 30.12.2016
https://doi.org/10.17944/mkutfd.287769

Abstract

Aim:Treatment options for acoustic neuroma
are; microsurgery, stereotactic radiotherapy and the use of these two options
together. In this study, after treatment quality of life and changes in the
tumor size,hearing level of patientswhom were applied stereotactic radiotherapy
due to acoustic neuroma in our clinic were evaluated..

Material and Methods: In our clinic,
between September 2009 and May 2016 22 patients who had acoustic neuroma
smaller than 3 centimeter were evaluated retrospectively. The patients
underwent stereotactic radiotherapy with a dose of 12 Gray. Size was measured
before and after treatment with magnetic resonance and hearing level and speech
discriminations were calculated with audiogram.Their quality of life was
evaluated with SF-36 Quality of Life Assessment Scale after treatment.

Results: In both of these patients groups with
acoustic neuroma whose tumor is located at only internal auditory canal or at
cerebellopontine angle and internal auditory canal; it was showed that
stereotactic radiotherapy can cause hearing loss and decrease in speech
discrimination scores but this difference is not statistically significant
(P>0.05). In recent follow-up magnetic resonance imaging was taken and in 12
of these patients; sizes of the acoustic neuroma was stabil and on the other
hand in 2 of the patients there was a progression and in 8 of the patients
there was a regression. In the evaluation of Quality of Life Assessment Scale;
most decrease was found in vitality scores.







Conclusion: Stereotactic radiotherapy can be used with hearing
function, changes of tumor size and low morbidity in quality of life in
patients with diagnosis of acoustic neuroma under 3 centimeter.

References

  • Bisi MA, Selaimen CM, Chaves KD, Bisi MC, Grossi ML. Vestibular schwannoma (acoustic neuroma) mimicking temporomandibular disorders: a case report J Appl Oral Sci, 2006; 14:476-81.
  • Brackmann D, Arriaga M. Neoplasms of the posteriorfossa. In: Flint PW, ed. Cummings Otolaryngology: Headand Neck Surgery. 5th ed. Philadelphia, PA: Mosby Elsevier; 2010. chap 177. p. 1605-1615.
  • Jeyakumar A, Seth R, Brickman TM, Dutcher P.The prevalence and clinical course of patients with ‘incidental’ acoustic neuromas. Acta Otolaryngol 2007;127:1051.
  • Llópez Carratalá I, Escorihuela García V, Orts Alborch M, de PaulaVernetta C, MarcoAlgarra J. Radiosurgery as Treatment for Acoustic Neuroma Ten Years’ Experience Acta Otorrinolaringol Esp. 2014;65:327-31.
  • Karpinos M, Teh BS, Zeck O, Carpenter LS, Phan C, Mai WY, et al. Treatment of acoustic neuroma: stereotactic radiosurgery vs microsurgery. Int J Rad Oncol Biol Phys. 2002; 5:1410-21.
  • Chopra R, Kondziolka D, Niranjan A, Lunsford LD, Flickinger JC. Long-term follow-up of acoustic schwannoma radiosurgery with marginal tumor doses of 12 to 13 Gy. Int J Radiat Oncol Biol Phys. 2007;68:845-51.
  • Wangerid T, Bartek J Jr, Svensson M, Förander P. Long-term quality of life and tumour control following gamma knife radiosurgery for vestibular schwannoma. Acta Neurochir (Wien). 2014;156:389-96.
  • Forster DM, Kemeny AA, Pathak A, Walton L. Radiosurgery: a minimally interventional alternative to microsurgery in the management ofacoustic neuroma. Br J Neurosurg. 1996;10:169-74.
  • Pollack BE, Lunsford DL, KondziolkaD,Flickinger JC, Bissonette DJ, KelseySF,et al. Outcome analysis of acoustic neuroma management: A comparison of microsurgery and stereotactic radiosurgery. Neurosurgery 1995;36:215–24.
  • Godefroy WP, Kaptein AA, Vogel JJ, Van Der Mey AGL. Conservative treatment of vestibular schwannoma: a follow-up study on clinical and quality-of-life outcome. Otol Neurotol 2009;30:968–74.
  • Shaffer BT, Cohen MS, Bigelow DC, Ruckenstein MJ. Validation of a disease-specific quality-of-life instrument for acoustic neuroma: the Penn Acoustic Neuroma Quality-of-Life Scale.Laryngoscope. 2010;120:1646-54k Psikiyatri Derg. 2007; 18(1):31–7.

STEREOTAKTİK RADYOTERAPİNİN AKUSTİK NÖRİNOMA HASTALARI ÜZERİNE ETKİSİ

Year 2016, Volume: 7 Issue: 28, 25 - 30, 30.12.2016
https://doi.org/10.17944/mkutfd.287769

Abstract

Amaç: Akustik nörinoma için tedavi seçenekleri,
mikrocerrahi, stereotaktik radyoterapi ve her ikisinin birlikte kullanımıdır.
Bu çalışmamızda, kliniğimizde akustik nörinoma nedenli stereotaktik radyoterapi
uyguladığımız hastaların tedavi sonrası kitle boyutlarındaki, işitme
düzeylerindeki değişimler ve yaşam kalitesi değerlendirildi.



Gereç ve Yöntem: Eylül 2009 ile
Mayıs 2016 tarihleri arasında kliniğimizde üç santimetreden küçük akustik
nörinoma saptanmış 22 hasta retrospektif olarak değerlendirildi. Hastalara
stereotaktik radyoterapi ile 12 Gray doz uygulandı. Magnetik rezonans ile
tedavi öncesi ve sonrası boyutları ve odyogramda işitme düzeyleri ve konuşmayı
ayırt etme skorları hesaplandı. Tedavi sonrası SF-36 Yaşam Kalitesi
Değerlendirme Ölçeği ile yaşam kaliteleri değerlendirildi.



Bulgular: Stereotaktik radyoterapinin hem sadece
internal akustik kanalda yerleşim gösteren hem de serebellopontin köşe ve
internal akustik kanalda birlikte yerleşim gösteren akustik nörinoma
hastalarında işitme kaybına ve konuşmayı ayırt etme eşiği skorlarında düşmeye
sebep olduğu ancak istatiksel olarak anlamlı olmadığı görüldü (P>0,05). Son
kontrollerinde çekilen magnetik rezonansta 12'sinin akustik nörinoma boyutları
stabil seyrederken, 2'sinde boyutlarda progresyon ve 8'inin boyutlarda
regresyon izlendi. Yaşam Kalitesi Değerlendirme Ölçeği değerlendirme sonucunda
en fazla canlılık skorlamasında düşme olduğu izlendi.



Sonuç: Stereotaktik radyoterapi 3 santimetre
altındaki akustik nörinoma tanısı almış hastalarda işitme fonksiyonu, kitle
boyutlarındaki değişim ve yaşam kalitesinde düşük morbitideyle birlikte
kullanılabilmektedir.

References

  • Bisi MA, Selaimen CM, Chaves KD, Bisi MC, Grossi ML. Vestibular schwannoma (acoustic neuroma) mimicking temporomandibular disorders: a case report J Appl Oral Sci, 2006; 14:476-81.
  • Brackmann D, Arriaga M. Neoplasms of the posteriorfossa. In: Flint PW, ed. Cummings Otolaryngology: Headand Neck Surgery. 5th ed. Philadelphia, PA: Mosby Elsevier; 2010. chap 177. p. 1605-1615.
  • Jeyakumar A, Seth R, Brickman TM, Dutcher P.The prevalence and clinical course of patients with ‘incidental’ acoustic neuromas. Acta Otolaryngol 2007;127:1051.
  • Llópez Carratalá I, Escorihuela García V, Orts Alborch M, de PaulaVernetta C, MarcoAlgarra J. Radiosurgery as Treatment for Acoustic Neuroma Ten Years’ Experience Acta Otorrinolaringol Esp. 2014;65:327-31.
  • Karpinos M, Teh BS, Zeck O, Carpenter LS, Phan C, Mai WY, et al. Treatment of acoustic neuroma: stereotactic radiosurgery vs microsurgery. Int J Rad Oncol Biol Phys. 2002; 5:1410-21.
  • Chopra R, Kondziolka D, Niranjan A, Lunsford LD, Flickinger JC. Long-term follow-up of acoustic schwannoma radiosurgery with marginal tumor doses of 12 to 13 Gy. Int J Radiat Oncol Biol Phys. 2007;68:845-51.
  • Wangerid T, Bartek J Jr, Svensson M, Förander P. Long-term quality of life and tumour control following gamma knife radiosurgery for vestibular schwannoma. Acta Neurochir (Wien). 2014;156:389-96.
  • Forster DM, Kemeny AA, Pathak A, Walton L. Radiosurgery: a minimally interventional alternative to microsurgery in the management ofacoustic neuroma. Br J Neurosurg. 1996;10:169-74.
  • Pollack BE, Lunsford DL, KondziolkaD,Flickinger JC, Bissonette DJ, KelseySF,et al. Outcome analysis of acoustic neuroma management: A comparison of microsurgery and stereotactic radiosurgery. Neurosurgery 1995;36:215–24.
  • Godefroy WP, Kaptein AA, Vogel JJ, Van Der Mey AGL. Conservative treatment of vestibular schwannoma: a follow-up study on clinical and quality-of-life outcome. Otol Neurotol 2009;30:968–74.
  • Shaffer BT, Cohen MS, Bigelow DC, Ruckenstein MJ. Validation of a disease-specific quality-of-life instrument for acoustic neuroma: the Penn Acoustic Neuroma Quality-of-Life Scale.Laryngoscope. 2010;120:1646-54k Psikiyatri Derg. 2007; 18(1):31–7.
There are 11 citations in total.

Details

Subjects Health Care Administration
Journal Section Original Articles
Authors

Suphi Bulğurcu

İlker Burak Arslan

Ömer Uğur This is me

İbrahim Çukurova This is me

Publication Date December 30, 2016
Submission Date May 11, 2016
Acceptance Date October 13, 2016
Published in Issue Year 2016 Volume: 7 Issue: 28

Cite

Vancouver Bulğurcu S, Arslan İB, Uğur Ö, Çukurova İ. The Effect Of Stereotactic Radiotherapy In Patients With Acoustic Neuroma. mkutfd. 2016;7(28):25-30.