Year 2020, Volume 11 , Issue 40, Pages 43 - 47 2020-08-30

Tonsillektomi spesmenlerinin Histopatolojik Retrospektif Analizi
Histopathologic Retrospective Analysis of Tonsillectomy Specimens

Sedat AYDIN [1] , Eren BOLDAZ [2]


Amaç: Tonsillektomi, özellikle pediyatrik yaş grubunda sıkça yapılan bir ameliyattır. Tonsillektomi spesmenlerinin rutin histopatolojik incelemesinin gerekliliği ise hala tartışmalı bir konudur. Çalışmamızda kliniğimizde son 5,5 yılda tonsillektomi operasyonu olmuş 12 yaş ve üstü hastaların tonsil materyallerinin histopatolojik dağılımını ve rutin patolojik incelemenin gerekliliği sorgulanmaktadır.

Gereç ve Yöntem: Hastanemiz kulak burun boğaz kliniğinde 2013 ocak ayı ve 2018 temmuz ayı tarihleri arasında çeşitli endikasyonlar ile tonsillektomi operasyonu olmuş 856 hastanın (452 erkek, 404 kadın; ortalama yaş: 34.6, yaş aralığı: 12-92 yaş) anamnezi, şikayetleri, fizik muayene sonuçları ve patolojik sonuçları incelenmiştir.

Bulgular: 856 hastanın patoloji sonuçları değerlendirildiğinde; 50 hastada (%6) malignite saptanmış olup bu hastaların 36’sında (%4) lenfoma, 11’inde (%1) skuamoz hücreli karsinom (SCC), 2’sinde (%0.2) adenokarsinom metastazı (akciğer ve pankreas adenokarsinomu metastazı), 1’inde (%0.1) malign melanom, 1’inde (%0.1) nöroendokrin tümör metastazı olduğu görülmüştür. Çalışmaya dahil edilen hastaların hiçbirinde rastlantısal malignite saptanmamıştır.

Sonuç: Literatürdeki çoğu çalışmada en sık görülen tonsil malignitesi skuamoz hücreli karsinom ikinci en sık görülen tonsil malignitesi ise lenfoma olarak belirtilmiştir. Çalışmamızda bu bilginin aksine %72’lik bir oranla en sık görülen tonsil malignitesi lenfoma, ikinci en sık görülen tonsil malignitesi ise skuamoz hücreli karsinom (SCC) olarak bulunmuştur. Lenfoma saptanan 36 hastanın 19’unda (%52) ise Diffüz Büyük B Hücreli Lenfoma (DBBHL) alt tipi görülmüş olup bu oran literatür verileri ile uyumlu bulunmuştur. Malignite saptanmış olan hastaların hepsinde malignite risk faktörü (asimetrik büyümüş, ülsere olmuş veya obsturiktif boyutlara ulaşmış tonsil dokusu, boyunda şişlik, yutma güçlüğü vs) olduğu görülmüş olup ve 856 hastanın hiçbirinde rastlantısal malignite saptanmamıştır. Sonuç olarak tonsillektomi spesmenlerinin rutin histopatolojik incelenmesi gerekli olmayabilir ancak risk faktörü taşıyan hastalarda mutlaka histopatolojik inceleme yapılmalıdır. 

Aim: Tonsillectomy is a frequent surgical operation in every otolaryngology clinic, especially in the pediatric age group. Pathologic examination of tonsillectomy specimens routinely remains a controversial issue. In this study, we investigated the histopathologic distribution of tonsillectomy materials and the necessity of routine pathologic examination in adult patients who underwent tonsillectomy operation in our clinic for the last 5,5 years

Material and Methods: The tonsillectomy materials of 856 patients (452 males, 404 females, mean age: 34.6 years, range of age: 12-92 years) who underwent tonsillectomy operations between January 2013 and July 2018 in our otolaryngology clinic were examined histopathologically.

Results: Malignancy was observed in 50(6%) of 856 adult patients and malignancy distribution in these patients is like this; 36(%4) patients with lymphoma, 11(%1) patients with squamous cell carcinoma (SCC), 2(%0.2) patients with adenocarcinoma metastasis (lung and pancreatic adenocarcinoma), 1(%0.1) patient with neuroendocrine tumor metastasis

Conclusion: The most common cause of tonsillar malignancies in literature, is squamous cell carcinoma (SCC) and the second most common cause is lymphoma. In our study we found some information contrary to literature as the most common tonsillar malignancy was lymphoma with 72% and squamous cell carcinoma (SCC) is the second most common malignancy with frequent rate of % 22. Diffuse Large B Cell Lymphoma (DBBHL) was the most common malignancy with 19 patients (52%) in patients with lymphoma and this information is consistent with the literature. All patients with malignancy were clinically diagnosed with a malignancy risk factor such as asymmetric enlarged, ulcerated or obstructive tonsillar tissue, swelling in the neck or swallowing difficulty etc. And none of the 856 patients had malignancy. As a result, routine histopathologic examination may not be necessary in patients with tonsillectomy, but histopathologic examination should be performed in patients with have preoperative risk factors. 

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Primary Language tr
Subjects Health Care Sciences and Services
Journal Section Original Articles
Authors

Orcid: 0000-0003-4939-5026
Author: Sedat AYDIN (Primary Author)
Institution: İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ
Country: Turkey


Orcid: 0000-0001-9116-4542
Author: Eren BOLDAZ
Institution: İSTANBUL KARTAL DR. LÜTFİ KIRDAR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Country: Turkey


Dates

Application Date : February 2, 2019
Acceptance Date : August 7, 2020
Publication Date : August 30, 2020

Vancouver Aydın S , Boldaz E . Tonsillektomi spesmenlerinin Histopatolojik Retrospektif Analizi. Mustafa Kemal Üniversitesi Tıp Dergisi. 2020; 43-47.