Prostat Karsinomunun Moleküler Yolakları

Year 2020, Volume: 11 Issue: 41, 118 - 123, 01.12.2020

Zeynep Bayramoğlu Betül Ünal

https://doi.org/10.17944/mkutfd.755075

Abstract

Prostat kanseri, dünyada hızla artan insidans oranlarına sahip en yaygın kanser türlerinden biridir. Prostat kanseri insidansı ve mortalite oranları farklı popülasyonlarda büyük ölçüde değişkendir. Prostat kanseri, tümör baskılayıcı genlerin spesifik genom sekanslarında delesyon ve onkogen aktivasyonu ile ilişkili spesifik kromozomal bölgelerdeki değişiklikler gibi çoklu genetik modifikasyonları içerir. Prostat kanseri yol açan kalıtsal değişikliklerin bir veya daha fazla spesifik genetik özellik ile ilişkili olup olmadığını belirlemek zordur. Prostat karsinogenezi çok karmaşık olup hala mekanizmaları olarak açıklanmamıştır. Eğer prostat karsinogenezini daha iyi anlayabilirsek bu hastalar için hedefe yönelik tedavi de bulabiliriz. Bu nedenle biz burada prostat karsinomunda yer alan büyük genetik ve epigenetik değişikliklerden bahsetmek istedik.

Keywords

prostat karsinomu, moleküler yolaklar, tedavi, epigenetik

Molecular Pathways of Prostate Carcinoma

Abstract

Prostate cancer is one of the most common types of cancer with rapidly growing incidence rates in the world. The incidence and mortality rates of prostate cancer are widely variable in different populations. The prostate cancer includes multiple genetic modifications such as deletion in specific genome sequences of tumor-suppressor genes and alterations in specific chromosomal sites associated with oncogene activation. It is difficult to determine whether the hereditary changes leading to prostate cancer are associated with one or more specific genetic features. Prostate carcinogenesis is complex and has not been fully explained. If we can better understand prostate carcinogenesis, we can also find targeted therapy. Therefore, we talked about the major genetic and epigenetic changes involved in prostate carcinoma.

Keywords

prostate carcinoma, molecular pathways, treatment, epigenetic

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