Progressive Disseminated Adenoid Cystic Carcinoma as shown by follow up 18Flourine Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography: a rare case report

Year 2025, Volume: 5 Issue: 1, 17 - 20, 15.05.2025

Zehra Pınar Koç , Pınar Pelin Özcan , Vehbi Erçolak

https://doi.org/10.71286/moi.1696329

Abstract

The Adenoid Cystic Carcinoma of the head and neck usually present with lung metastasis in case of distant spread. There are also several case reports about other metastatic sites including kidney, brain and bone. However this is the first case with disseminated disease involvement including multiple skin lesions all over the body with follow up 18 F FDG PET/CT images.

Keywords

Adenoid cystic carcinoma , disseminated , FDG

References

• Jang, S., Patel, P. N., Kimple, R. J., & McCulloch, T. M. (2017). Clinical Outcomes and Prognostic Factors of Adenoid Cystic Carcinoma of the Head and Neck. Anticancer research, 37(6), 3045–3052. https://doi.org/10.21873/anticanres.11659
• Moghrabi, S., Al-Muhtaseb, A., Alshatti, M. Y., & Al-Ibraheem, A. (2025). Fluoro-2-Deoxyglucose (FDG)-Avid Adenoid Cystic Carcinoma of the Larynx: A Rare Case and Diagnostic Insight Obtained Using Positron Emission Tomography/Computed Tomography (PET/CT) Imaging. Cureus, 17(2), e78816. https://doi.org/10.7759/cureus.78816 Lee, R. H., Wai, K. C., Chan, J. W., Ha, P. K., & Kang, H. (2022). Approaches to the Management of Metastatic Adenoid Cystic Carcinoma. Cancers, 14(22), 5698. https://doi.org/10.3390/cancers14225698 Yao, Y., & Huang, R. (2022). Exceptional renal metastasis from adenoid cystic carcinoma of nasopharynx seen on 18F-FDG PET/CT. Hellenic journal of nuclear medicine, 25(2), 220–221. https://doi.org/10.1967/s002449912484
• Zhao, Q., Dong, A., Ye, H., & Zuo, C. (2022). 99mTc-MIBI SPECT/CT and FDG PET/CT in Isolated Bilateral Renal Metastases From Adenoid Cystic Carcinoma of the Maxilla. Clinical nuclear medicine, 47(2), e205–e207. https://doi.org/10.1097/RLU.0000000000003872 Gray, B. C., Gellatly, M. J., & Oldan, J. D. (2024). Metastatic Adenoid Cystic Carcinoma of the Bartholin Gland. Clinical nuclear medicine, 49(8), e425–e427. https://doi.org/10.1097/RLU.0000000000005329
• Sandach, P., Seifert, R., Slama, A., Theegarten, D., & Hautzel, H. (2023). Histological Validation of FDG and PSMA-Targeted PET/CT Imaging in a Rare Tracheal Adenoid Cystic Carcinoma. Clinical nuclear medicine, 48(1), e16–e18. https://doi.org/10.1097/RLU.0000000000004441 Liang, Z., Ding, Y., Sui, H., Wu, M., Jin, Y., & Wen, W. (2024). Identification of hepatic metastasis from an unrevealed adenoid cystic carcinoma by PET/CT: A case report. Medicine, 103(38), e39769. https://doi.org/10.1097/MD.0000000000039769
• Otsuka, K., Otsuka, M., Matsunaga, T., Hirano, T., Abe, M., Osoegawa, A., Sugio, K., Daa, T., & Asayama, Y. (2024). Low FDG uptake in lung metastasis despite high FDG uptake in a primary adenoid cystic carcinoma of a sublingual gland. Radiology case reports, 19(8), 3195–3199. https://doi.org/10.1016/j.radcr.2024.04.037
• Wang Z, Liu Z, Zhuang L, Yin W, Zhao Y, Dong M. Case report: [(18)F]FAPI-42 PET/CT visualize primary adenoid cysticcarcinoma not detected by [(18)F]FDG. Am J Nucl Med Mol Imaging. 2024 Apr 25;14(2):157-160.
• Civan, C., Isik, E. G., Has Simsek, D., Buyukkaya, F., & Kuyumcu, S. (2023). Utility of 68 Ga-FAPI-04 PET/CT in Adenoid Cystic Carcinoma Compared With 18 F-FDG PET/CT : Two Case Reports. Clinical nuclear medicine, 48(7), e350–e352. https://doi.org/10.1097/RLU.0000000000004687 Shamim, S. A., Kumar, N., Arora, G., Kumar, D., Pathak, A., Thakkar, A., Sikka, K., Singh, C. A., Kakkar, A., & Bhalla, A. S. (2023). Comparison of 68Ga-PSMA-HBED-CC and 18F-FDG PET/CT in the Evaluation of Adenoid Cystic Carcinoma-A Prospective Study. Clinical nuclear medicine, 48(11), e509–e515. https://doi.org/10.1097/RLU.0000000000004868 Isgoren, S., Hekimsoy, T., Koroglu, E., & Demir, H. (2022). PET/CT With 68Ga-PSMA and 18F-FDG in Metastatic Adenoid Cystic Carcinoma: Report of 2 Cases. Clinical nuclear medicine, 47(5), e423–e424. https://doi.org/10.1097/RLU.0000000000004106 Wang, G., Zhou, M., Zang, J., Jiang, Y., Chen, X., Zhu, Z., & Chen, X. (2022). A pilot study of 68 Ga-PSMA-617 PET/CT imaging and 177Lu-EB-PSMA-617 radioligand therapy in patients with adenoid cystic carcinoma. EJNMMI research, 12(1), 52. https://doi.org/10.1186/s13550-022-00922-x Has Simsek, D., Kuyumcu, S., Agaoglu, F. Y., & Unal, S. N. (2019). Radionuclide Therapy With 177Lu-PSMA in a Case of Metastatic Adenoid Cystic Carcinoma of the Parotid. Clinical nuclear medicine, 44(9), 764–766. https://doi.org/10.1097/RLU.0000000000002645
• Sun, X., Gu, W., Yuan, H., Wang, S., Yang, Y., Evangelista, L., Zhang, L., & Jiang, L. (2022). Clinical use of 18F-FDG PET/CT in the differential diagnosis of patients with primary and secondary adenoid cystic carcinoma of the lung: a retrospective cohort study. Translational lung cancer research, 11(8), 1643–1656. https://doi.org/10.21037/tlcr-22-509
• Lim, W. S., Oh, J. S., Roh, J. L., Kim, J. S., Kim, S. J., Choi, S. H., Nam, S. Y., & Kim, S. Y. (2018). Prediction of distant metastasis and survival in adenoid cystic carcinoma using quantitative 18F-FDG PET/CT measurements. Oral oncology, 77, 98–104. https://doi.org/10.1016/j.oraloncology.2017.12.013
• Sürer Budak, E., Yıldırım, Ş., Yıldız, S., Öner, A. O., & Gündüz, Ş. (2017). Two Uncommon Sites of Metastasis: Breast and Hypophysis Metastases of Head and Neck Adenoid Cystic Carcinoma Detected by FDG PET/CT. Baş Boyun Adenoid Kistik Karsinomlu Olguda İki Olağan Dışı Metastaz Alanı: Hipofiz ve Meme. Molecular imaging and radionuclide therapy, 26(3), 120–123. https://doi.org/10.4274/mirt.06025
• Tewari, A., Padma, S., & Sundaram, P. S. (2013). Detection of atypical metastases in recurrent adenoid cystic carcinoma of parotid gland. Journal of cancer research and therapeutics, 9(1), 148–150. https://doi.org/10.4103/0973-1482.110374