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Serotonin syndrome with low-dose escitalopram

Year 2013, , 37 - 40, 01.01.2013
https://doi.org/10.5455/jmood.20121022031644

Abstract

Serotonin syndrome is a drug side effect resulting from serotonergic hyperactivity. At times the severity of its symptoms can be mild and overlooked, but sometimes it might cause life-threatening serious consequences. It usually occurs while using high doses or combinations of serotonergic drugs. However, it might also be observed during the use of low dose of serotonergic agents, even it is rare. In this paper, it is aimed to present a case with serotonin syndrome which is thought to be developed after the use of 5 mg of escitalopram, and to discuss this case in terms of differential diagnosis.

References

  • Altınyazar V. Psikiyatride Güncel Yaklaşımlar Current Approaches in Psychiatry. 2010;2:532 71.
  • Sternbach H. The serotonin syndrome. Am J Psychiatry. 1991;148:705-13.
  • Yüksel N. Antidepresan ilaçlar. Psikofarmakoloji, Yenilenmiş 2. Baskı, Çizgi Yayınevi, Ankara, 2003.
  • Özdemir S, Kocabaşoğlu N. Serotonin Sendromuna Güncel Bir Yaklaşım. Klinik Psikofarmakoloji Bülteni. 2007;17:217-25.
  • Küçükardalı Y, Çankır Z, Ebrinç S, Nalbant S, Başoğlu C, Evrenkaya R, Top C, Danacı M. Moklobemid - klomipramin etkileşimi nedenli serotonin sendromu. Klinik Psikofarmakoloji Bülteni. 2001;11:33-6.
  • FitzSimmons CR, Metha S. Serotonin syndrome caused by overdose with paroxetine and moclobemide. J Accid Emerg Med. 1999;16:293-5.
  • Wu ML, Deng JF. Serotonin toxicity caused by moclobemide too soon after paroxetine-selegiline. J Chin Med Assoc. 2009;72:446-9.
  • Bhatara VS, Magnus RD, Paul KL, Preskorn SH. Serotonin syndrome induced by venlafaxine and fluoxetine: a case study in polypharmacy and potential pharmacodynamic and pharmacokinetic mechanisms. Ann Pharmacother. 1998;32:432-6.
  • Demers JC, Malone M. Serotonin syndrome induced by fluvoxamine and mirtazapine. Ann Pharmacother. 2001;35:1217
  • Sarısoy G, Kaçar ÖF, Pazvantoğlu O. Duloksetin-siprofloksasin birlikte kullanımıyla ilişkili serotonin sendromu: Olgu bildirimi. Klinik Psikofarmakoloji Bülteni. 2012;22:79-82.
  • Graber MA, Hoehns TB, Perry PJ. Sertraline-phenelzine drug interaction: a serotonin syndrome reaction. Ann Pharmacother. 1994;28:732-5.
  • Adan-Manes J, Novalbos J, López-Rodríguez R, Ayuso-Mateos JL, Abad-Santos F. Lithium and venlafaxine interaction: a case of serotonin syndrome. J Clin Pharm Ther. 2006;31:397-400.
  • Fisher AA, Davis MW. Serotonin syndrome caused by selective serotonin reuptake-inhibitors-metoclopramide interaction. Ann Pharmacother. 2002;36:67-71.
  • Vandemergel X, Beukinga I, Nève P.Serotonin syndrome secondary to the use of sertraline and metoclopramide. Rev Med Brux. 2000;21:161-3.
  • Tseng WP, Tsai JH, Wu MT, Huang CT, Liu HW. Citolopram– induced serotonin syndrome: a case report. Kaohsiung J Med Sci. 2005;21:326-7.
  • Kan R, Endou M, Unno Y. A case of serotonin syndrome following minimum doses of sertraline. Seishin Shinkeigaku Zasshi. 2009;111:1041-6.
  • Pan JJ, Shen WW. Serotonin syndrome induced by low-dose venlafaxine. Ann Pharmacother. 2003;37:209-11.
  • Gelener P, Gorgulu U, Kutlu G, Ucler S, Inan LE. Serotonin syndrome due to duloxetine. Clin Neuropharmacol. 2011;34:127-8. Phan H, Casavant MJ, Crockett S, Lee A, Hall MW, Nahata MC. Serotonin syndrome following a single 50 mg dose of sertraline in a child. Clin Toxicol (Phila). 2008;46:845-9.
  • Arık AC. Serotonin Sendromu. Duygudurum Bozuklukları Dizisi 2003;1:346-351.

Düşük doz essitalopram ile serotonin sendromu

Year 2013, , 37 - 40, 01.01.2013
https://doi.org/10.5455/jmood.20121022031644

Abstract

Serotonin sendromu serotonerjik aşırı etkinlik sonucu oluşan bir ilaç yan etkisidir. Hafif şiddette olup gözden kaçabildiği gibi hayatı tehdit eden ciddi sonuçları olabilmektedir. Genellikle serotonerjik ilaçların yüksek dozda veya başka ilaçlarla beraber kullanımları sırasında ortaya çıkmaktadır. Ancak nadir de olsa serotonerjik ajanların düşük dozda kullanımına bağlı olarak görülebilmektedir. Bu olgu sunumunda essitalopram 5 mg kullanımı sonrası serotonin sendromu geliştiği düşünülen bir olgunun sunulması ve ayırıcı tanı açısından tartışılması amaçlanmıştır.

References

  • Altınyazar V. Psikiyatride Güncel Yaklaşımlar Current Approaches in Psychiatry. 2010;2:532 71.
  • Sternbach H. The serotonin syndrome. Am J Psychiatry. 1991;148:705-13.
  • Yüksel N. Antidepresan ilaçlar. Psikofarmakoloji, Yenilenmiş 2. Baskı, Çizgi Yayınevi, Ankara, 2003.
  • Özdemir S, Kocabaşoğlu N. Serotonin Sendromuna Güncel Bir Yaklaşım. Klinik Psikofarmakoloji Bülteni. 2007;17:217-25.
  • Küçükardalı Y, Çankır Z, Ebrinç S, Nalbant S, Başoğlu C, Evrenkaya R, Top C, Danacı M. Moklobemid - klomipramin etkileşimi nedenli serotonin sendromu. Klinik Psikofarmakoloji Bülteni. 2001;11:33-6.
  • FitzSimmons CR, Metha S. Serotonin syndrome caused by overdose with paroxetine and moclobemide. J Accid Emerg Med. 1999;16:293-5.
  • Wu ML, Deng JF. Serotonin toxicity caused by moclobemide too soon after paroxetine-selegiline. J Chin Med Assoc. 2009;72:446-9.
  • Bhatara VS, Magnus RD, Paul KL, Preskorn SH. Serotonin syndrome induced by venlafaxine and fluoxetine: a case study in polypharmacy and potential pharmacodynamic and pharmacokinetic mechanisms. Ann Pharmacother. 1998;32:432-6.
  • Demers JC, Malone M. Serotonin syndrome induced by fluvoxamine and mirtazapine. Ann Pharmacother. 2001;35:1217
  • Sarısoy G, Kaçar ÖF, Pazvantoğlu O. Duloksetin-siprofloksasin birlikte kullanımıyla ilişkili serotonin sendromu: Olgu bildirimi. Klinik Psikofarmakoloji Bülteni. 2012;22:79-82.
  • Graber MA, Hoehns TB, Perry PJ. Sertraline-phenelzine drug interaction: a serotonin syndrome reaction. Ann Pharmacother. 1994;28:732-5.
  • Adan-Manes J, Novalbos J, López-Rodríguez R, Ayuso-Mateos JL, Abad-Santos F. Lithium and venlafaxine interaction: a case of serotonin syndrome. J Clin Pharm Ther. 2006;31:397-400.
  • Fisher AA, Davis MW. Serotonin syndrome caused by selective serotonin reuptake-inhibitors-metoclopramide interaction. Ann Pharmacother. 2002;36:67-71.
  • Vandemergel X, Beukinga I, Nève P.Serotonin syndrome secondary to the use of sertraline and metoclopramide. Rev Med Brux. 2000;21:161-3.
  • Tseng WP, Tsai JH, Wu MT, Huang CT, Liu HW. Citolopram– induced serotonin syndrome: a case report. Kaohsiung J Med Sci. 2005;21:326-7.
  • Kan R, Endou M, Unno Y. A case of serotonin syndrome following minimum doses of sertraline. Seishin Shinkeigaku Zasshi. 2009;111:1041-6.
  • Pan JJ, Shen WW. Serotonin syndrome induced by low-dose venlafaxine. Ann Pharmacother. 2003;37:209-11.
  • Gelener P, Gorgulu U, Kutlu G, Ucler S, Inan LE. Serotonin syndrome due to duloxetine. Clin Neuropharmacol. 2011;34:127-8. Phan H, Casavant MJ, Crockett S, Lee A, Hall MW, Nahata MC. Serotonin syndrome following a single 50 mg dose of sertraline in a child. Clin Toxicol (Phila). 2008;46:845-9.
  • Arık AC. Serotonin Sendromu. Duygudurum Bozuklukları Dizisi 2003;1:346-351.
There are 19 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Neşe Öztürk This is me

Ezgi Kara This is me

Gülfizar Sözeri-varma This is me

Eylem Değirmenci This is me

Publication Date January 1, 2013
Published in Issue Year 2013

Cite

APA Öztürk, N., Kara, E., Sözeri-varma, G., Değirmenci, E. (2013). Düşük doz essitalopram ile serotonin sendromu. Journal of Mood Disorders, 3(1), 37-40. https://doi.org/10.5455/jmood.20121022031644
AMA Öztürk N, Kara E, Sözeri-varma G, Değirmenci E. Düşük doz essitalopram ile serotonin sendromu. Journal of Mood Disorders. January 2013;3(1):37-40. doi:10.5455/jmood.20121022031644
Chicago Öztürk, Neşe, Ezgi Kara, Gülfizar Sözeri-varma, and Eylem Değirmenci. “Düşük Doz Essitalopram Ile Serotonin Sendromu”. Journal of Mood Disorders 3, no. 1 (January 2013): 37-40. https://doi.org/10.5455/jmood.20121022031644.
EndNote Öztürk N, Kara E, Sözeri-varma G, Değirmenci E (January 1, 2013) Düşük doz essitalopram ile serotonin sendromu. Journal of Mood Disorders 3 1 37–40.
IEEE N. Öztürk, E. Kara, G. Sözeri-varma, and E. Değirmenci, “Düşük doz essitalopram ile serotonin sendromu”, Journal of Mood Disorders, vol. 3, no. 1, pp. 37–40, 2013, doi: 10.5455/jmood.20121022031644.
ISNAD Öztürk, Neşe et al. “Düşük Doz Essitalopram Ile Serotonin Sendromu”. Journal of Mood Disorders 3/1 (January 2013), 37-40. https://doi.org/10.5455/jmood.20121022031644.
JAMA Öztürk N, Kara E, Sözeri-varma G, Değirmenci E. Düşük doz essitalopram ile serotonin sendromu. Journal of Mood Disorders. 2013;3:37–40.
MLA Öztürk, Neşe et al. “Düşük Doz Essitalopram Ile Serotonin Sendromu”. Journal of Mood Disorders, vol. 3, no. 1, 2013, pp. 37-40, doi:10.5455/jmood.20121022031644.
Vancouver Öztürk N, Kara E, Sözeri-varma G, Değirmenci E. Düşük doz essitalopram ile serotonin sendromu. Journal of Mood Disorders. 2013;3(1):37-40.