Düşük doz essitalopram ile serotonin sendromu

Neşe Öztürk; Ezgi Kara; Gülfizar Sözeri-varma; Eylem Değirmenci

doi:10.5455/jmood.20121022031644

Serotonin syndrome with low-dose escitalopram

Yıl 2013, , 37 - 40, 01.01.2013

Neşe Öztürk Ezgi Kara Gülfizar Sözeri-varma Eylem Değirmenci

https://doi.org/10.5455/jmood.20121022031644

Öz

Serotonin syndrome is a drug side effect resulting from serotonergic hyperactivity. At times the severity of its symptoms can be mild and overlooked, but sometimes it might cause life-threatening serious consequences. It usually occurs while using high doses or combinations of serotonergic drugs. However, it might also be observed during the use of low dose of serotonergic agents, even it is rare. In this paper, it is aimed to present a case with serotonin syndrome which is thought to be developed after the use of 5 mg of escitalopram, and to discuss this case in terms of differential diagnosis.

Anahtar Kelimeler

serotonergic syndrome, selective serotonin reuptake inhibitors, side effects

Kaynakça

Altınyazar V. Psikiyatride Güncel Yaklaşımlar Current Approaches in Psychiatry. 2010;2:532 71.
Sternbach H. The serotonin syndrome. Am J Psychiatry. 1991;148:705-13.
Yüksel N. Antidepresan ilaçlar. Psikofarmakoloji, Yenilenmiş 2. Baskı, Çizgi Yayınevi, Ankara, 2003.
Özdemir S, Kocabaşoğlu N. Serotonin Sendromuna Güncel Bir Yaklaşım. Klinik Psikofarmakoloji Bülteni. 2007;17:217-25.
Küçükardalı Y, Çankır Z, Ebrinç S, Nalbant S, Başoğlu C, Evrenkaya R, Top C, Danacı M. Moklobemid - klomipramin etkileşimi nedenli serotonin sendromu. Klinik Psikofarmakoloji Bülteni. 2001;11:33-6.
FitzSimmons CR, Metha S. Serotonin syndrome caused by overdose with paroxetine and moclobemide. J Accid Emerg Med. 1999;16:293-5.
Wu ML, Deng JF. Serotonin toxicity caused by moclobemide too soon after paroxetine-selegiline. J Chin Med Assoc. 2009;72:446-9.
Bhatara VS, Magnus RD, Paul KL, Preskorn SH. Serotonin syndrome induced by venlafaxine and fluoxetine: a case study in polypharmacy and potential pharmacodynamic and pharmacokinetic mechanisms. Ann Pharmacother. 1998;32:432-6.
Demers JC, Malone M. Serotonin syndrome induced by fluvoxamine and mirtazapine. Ann Pharmacother. 2001;35:1217
Sarısoy G, Kaçar ÖF, Pazvantoğlu O. Duloksetin-siprofloksasin birlikte kullanımıyla ilişkili serotonin sendromu: Olgu bildirimi. Klinik Psikofarmakoloji Bülteni. 2012;22:79-82.
Graber MA, Hoehns TB, Perry PJ. Sertraline-phenelzine drug interaction: a serotonin syndrome reaction. Ann Pharmacother. 1994;28:732-5.
Adan-Manes J, Novalbos J, López-Rodríguez R, Ayuso-Mateos JL, Abad-Santos F. Lithium and venlafaxine interaction: a case of serotonin syndrome. J Clin Pharm Ther. 2006;31:397-400.
Fisher AA, Davis MW. Serotonin syndrome caused by selective serotonin reuptake-inhibitors-metoclopramide interaction. Ann Pharmacother. 2002;36:67-71.
Vandemergel X, Beukinga I, Nève P.Serotonin syndrome secondary to the use of sertraline and metoclopramide. Rev Med Brux. 2000;21:161-3.
Tseng WP, Tsai JH, Wu MT, Huang CT, Liu HW. Citolopram– induced serotonin syndrome: a case report. Kaohsiung J Med Sci. 2005;21:326-7.
Kan R, Endou M, Unno Y. A case of serotonin syndrome following minimum doses of sertraline. Seishin Shinkeigaku Zasshi. 2009;111:1041-6.
Pan JJ, Shen WW. Serotonin syndrome induced by low-dose venlafaxine. Ann Pharmacother. 2003;37:209-11.
Gelener P, Gorgulu U, Kutlu G, Ucler S, Inan LE. Serotonin syndrome due to duloxetine. Clin Neuropharmacol. 2011;34:127-8. Phan H, Casavant MJ, Crockett S, Lee A, Hall MW, Nahata MC. Serotonin syndrome following a single 50 mg dose of sertraline in a child. Clin Toxicol (Phila). 2008;46:845-9.
Arık AC. Serotonin Sendromu. Duygudurum Bozuklukları Dizisi 2003;1:346-351.