Obstrüktis Uyku Apnesi Olan Hastalarda Hastalık Şiddeti ile CRP/Prealbümin Oranı Arasındaki İlişki

Abstract

Giriş: Obstrüktif Uyku Apne Sendromu (OUAS) yaygın bir uyku hastalığıdır. Yüksek CRP düzeylerinin şiddetli OUAS durumunda yükseldiği saptanmıştır. CRP/Prealbümin (CRP/PAB) oranı ölüm riski ve kötü sonuçlar açısından yeni bir indekstir. CRP/PAB oranı ile OUAS şiddetini kıyaslanması amaçlanmıştır. Materyal ve Metod: Kesitsel bu çalışmada OUAS tanılı 99 hasta (ortalama yaş: 54.34±10.3) AHI kriterine dayalı olarak OUAS şiddeti durumuna göre hafif (n: 28 [28.3%]), orta (n:23 [23.2%]) ve şiddetli (n:48 [48.5%]) 3 sınıfa ayrılmıştır. Bulgular: Ortalama CRP/PAB oranı gruplar arasında benzer saptandı (hafif: 0.03± 0.03; orta: 0.02 ± 0.02, şiddetli: 0.03 ± 0.04, p=0.759). Demografik ve bazal özellikler gruplar arasında benzer saptandı. CRP/PAB oranı ile yaş, BMI, şeker, nötrofil, platelet ve monocit değerleri ile pozitif yönde ve Hgb, MCH, MCHC değerleri ile negatif yönde zayıf korelasyon saptandı (p<0.05). Tüm grupların değerlendirilmesinde regresyon analizi CRP/PAB oranı ile uyku süresi, apne ve hipopne indeksleri arasında zayıf ama anlamlı pozitif ilişki saptandı. Ayrıca uyku etkinliği ile zayıf ama anlamlı negatif ilişki saptandı (tümü için p<0.05). Sonuç: Her ne kadar CRP/PAB oranı ile OUAS şiddeti arasında anlamlı bağlantı saptanmasa da CRP/PAB oranı ile BMI, monosit sayısı arasında pozitif ama zayıf bir korelasyon ve apne ve hipopne indeksleri ile düşük düzeyde ilişki saptandı bu CRP/PAB oranının OUAS'daki inflamasyonun anlamlı bir belirteci olabileceğini ifade eder.

Keywords

• CRP
• CRP/Prealbumin
• İnflamasyon
• OUAS
• Prealbumin

The Relationship Between Disease Severity and CRP/Prealbumin Ratio in Individuals Diagnosed with Obstructive Sleep Apnea Syndrome

Abstract

Introduction: Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder. Higher CRP levels has been found to rise in severe OSAS. The CRP/Prealbumin (CRP/PAB) ratio is a new index of risk of death and poor outcomes. We aimed to compare the CRP/PAB ratio with the severity of OSAS. Material and Methods: In this cross-sectional study, 99 patients with OSAS (mean age=54.34±10.3) were classified into three categories based on severity of OSAS into mild (n: 28 [28.3%]), moderate (n:23 [23.2%]), and severe (n:48 [48.5%]) based on AHI criteria. Results: The mean CRP/PAB ratios were similar among the groups (mild: 0.03± 0.03; moderate=0.02 ± 0.02; severe=0.03 ± 0.04; p=0.759). The demographic and baseline features were similar between the groups. The CRP/PAB ratio had a weak positive correlation with the age, BMI, glucose, neutrophil, platelet and monocyte values and a weak negative correlation with the Hgb, MCH and MCHC values (p<0.05). Considering all groups in the regression analysis, it was showed that low levels of positive and significant relationship between the CRP/PAB and sleep duration and the apnea and hypopnea indices. It was also showed low-level of negative and significant relationship with sleep efficiency (p<0.05 for all). Conclusion: Although, there was no significant between the CRP/PAB ratio and the severity of OSAS, it was showed that low-level positive correlation between CRP/PAB ratio and BMI, monocyte count and low-level relationship with the apnea and hypopnea indices and it may indirectly mean that CRP/PAB ratio may be a significant marker of inflammation in OSAS.

Keywords

• CRP
• CRP/Prealbumin
• Inflammation
• OSAS
• Prealbumin

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