Gebelik, Emzirme Dönemi Sırasında Endokrin Bozucu Kimyasallara Maruz Kalma ve Yaşam Tarzı Alışkanlıklarının Gelişimsel Mine Defektleri ile İlişkisi: Bir Pilot Anket Çalışması

Abstract

Amaç: Bu çalışmanın amacı, gebelik ve emzirme dönemlerinde günlük yaşamda kullanılan endokrin bozucu kimyasallar ile gelişimsel mine defektleri (GMD) ve Molar İnsizör Hipomineralizasyon (MIH) varlığı arasındaki ilişkiyi değerlendirmektir.Yöntem: Bu tanımlayıcı ve kesitsel çalışmaya, pedodonti kliniğinde rutin diş muayenesi için başvuran, yaşları 8 ile 11 arasında değişen toplam 313 (n=313) çocuk ve ebeveynleri dahil edilmiştir. Katılımcıların dahil edilmesinden önce çalışma, Sağlık Bilimleri Üniversitesi Hamidiye Bilimsel Etik Araştırma Komitesi tarafından onaylanmıştır (22-591). Onam formlarının doldurulmasının ardından, katılımcılar anket sorularını QR kodlar aracılığıyla kendi telefonlarından yanıtlamıştır. Çocukların dental muayeneleri gerçekleştirilmiş ve dişlerin durumu mine defektleri açısından belgelenmiştir. Ağız içi bulgulardan elde edilen kategorik değişkenler arasındaki ilişkiler ki-kare analizi ile incelenmiş olup analizler, %95 güven aralığında SPSS 20.0 yazılımı kullanılarak gerçekleştirilmiştir.Bulgular: MIH prevalansı %36 (n=114) ve GMD prevalansı %3 (n=10) olarak tespit edilmiştir. Popülasyonun %4’ünde (n=15) alt kesici dişlerde defektler gözlenmiştir. Emzirme döneminde paketlenmiş gıda tüketimi ile MIH arasında anlamlı bir ilişki bulunmuştur (p < 0,05). Ayrıca, gebelik sırasında ilaç kullanımının MIH ve GMD görülme sıklığı ile istatistiksel olarak anlamlı bir ilişki gösterdiği saptanmıştır.Sonuç: Gebelik ve emzirme döneminde paketlenmiş gıda tüketimi, gelişimsel mine defektleri ve Molar-İnsizör Hipomineralizasyon (MIH) olasılığı ile ilişkilendirilmiştir. Endokrin bozucu kimyasalların etkileri üzerine daha kapsamlı çalışmalara ihtiyaç duyulmaktadır.

Keywords

• gelişimsel mine defektleri
• endokrin bozucular
• molar hipomineralizasyon

Maternal Exposure to Endocrine Disruptors, Lifestyle Factors, and Developmental Enamel Defects: A Pilot Study

Abstract

Aim: The aim of this study is to evaluate the relationship between endocrine disruptor chemicals using in the daily routine during breastfeeding and pregnancy period and the developmental enamel defects (DDE) and Molar Incisor Hypomineralization (MIH) presence. Method: 313 (n=313) parents and their child who aged between 8 and 11, along with their parents, were enrolled in the study for routine dental check-ups at the pediatric dentistry clinic was included to this current study. This is a descriptional and cross-sectional study. Prior to participant enrolment, this study was approved by the Hamidiye Scientific Ethical Research Committee, University of Health Sciences (22-591). After consent forms were completed, the surveys' questions were scanned via QR codes on patients' phones for them to answer. The dental examination of the child was conducted, and the condition of the teeth was documented based on enamel defects. The relationship between categorical variables obtained from oral findings was examined through chi-square analysis, with analyses conducted using SPSS 20.0 software at a 95% confidence interval. Results: MIH prevalence was 36 % ( n=114) and DDE prevalence was 3% ( n=10). 4% (n=15) of the population have defects on lower incisor teeth. There is a significant relationship between the consumption of packaged foods during the breastfeeding period and the MIH group (p < 0.05). Also, it was observed that there is a statistically significant association between drug usage during pregnancy and the occurrence of MIH and DDE. Conclusion: The likelihood of developmental enamel defects and Molar-Incisor Hypomineralization (MIH) has been associated with the consumption of packaged foods during pregnancy and lactation. Further comprehensive studies are needed regarding the use of endocrine-disrupting chemicals.

Keywords

• Developmental defects of enamel
• endocrine disruptors
• Molar Hypomineralization

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