Effects of Immunotherapy on T-lymphocyte and Cytokine Composition

Abstract

Abstract:

Objective, Materials and Methods: To examine the effect of immunotherapy (IT) on the level of serum interferon-gamma (IFN-g) and T-lymphocyte subgroups in allergic individuals, five study groups including 40 patients with allergic rhinitis and 10 healthy individuals were formed.

Group I:  10 participants whose IFN-g levels were measured before the IT administration

Group II:  10 participants whose IFN-g levels were measured after the IT administration

 Group III: 10 participants whose IFN-g levels were measured in the 3^rd control year after the IT administration

Group IV: 10 participants whose T4 and T8 lymphocyte levels were measured before and after the IT administration

Group V-Control group: 10 participants whose IFN-g levels were measured

Results: In Group I, serum IFN-g levels before the IT administration were examined and compared with that of the control group and no significant difference was found. In Group II, IFN-g levels after IT administration were investigated. IFN-g levels after IT administration were compared with those of Group I and the control group and a significant increase was observed in IFN-g level. Similarly, serum IFN-g levels in the 3^rd control year after IT administration in Group III were compared with those of the control group and Group I, and they were found significantly higher. T4, T8 levels and the rate of T4/ T8 in the peripheral blood before and after the IT administration in Group IV were examined.

Conclusion: There was a decrease in T4 level, an increase in T8 and decrease in the rate of T4/T8 after the IT administration.

 

Öz:

Amaç, materiyal ve metod: Allerjik bireylerde immunoterapinin (İT) serum interferon-gama (İFN-g) düzeyinde ve T-lenfosit subgruplarına olan etkisini araştırmak amacıyla 40 allerjik rinitli hasta ile 10 sağlıklı bireylerden beş çalışma grubu oluşturuldu.

I.                    Grup: İT öncesi İFN-g ölçülen 10 kişi

II.                 Grup: İT bitiminde İFN-g düzeyleri ölçülen 10 kişi

III.               Grup: İT bitiminden 3. kontrol yılında İFN-g düzeyleri ölçülen 10 kişi

IV.              Grup: İT öncesi ve sonrası T4,T8 lenfosit düzeyleri ölçülen 10 kişi

V.                Grup: kontrol grubu İFN-g düzeyleri ölçülen 10 kişi

Sonuç: I.grupta, İT öncesi serum İFN-g düzeyi bakılarak kontrol grubu ile karşılaştırıldı. İkisi arasında anlamlı bir fark bulunmadı.

II.grupta ise İT sonrası İFN-g düzeyine bakıldı. İT sonrası İFN-g düzeyi, I. grup ve kontrol grubu düzeyleri ile karşılaştırılarak İFN-g seviyesinde belirgin yükselme görüldü.

Aynı şekilde III. grupta İT sonrası 3. kontrol yılında bakılan serum İFN-g düzeyi, I. grup ve kontrol grubu düzeyleri ile karşılaştırılarak anlamlı miktarda yüksek bulundu.

IV. grupta ise İT öncesi ve sonrası periferik kandaki T4, T8 ve T4/T8miktarlarına bakıldı.

Tartışma: İT sonrasında T4 düzeyinde azalma, T8 düzeyinde artma ve T4/T8 oranında düşme görüldü.

 

Keywords

• İmmunotherapy,İnterferon-gamma,T-lymphocyte

References

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