Factors That May Affect FEV1 Change Of COPD Patients In One-Year Period

Abstract

INTRODUCTION: One of the hallmarks of COPD is the rate of FEV1 decline. There are many factors that may affect pulmonary parameters in a COPD patient. It was aimed to investigate the factors affecting FEV1 changes.

 

MATERIAL-METHODS: COPD outpatients who attended our pulmonology clinic were included. Spirometric values and inhaler device usage performance at that time and 12 months ago were compared.

 

RESULTS: Mean FEV1 values of 204 COPD patients decreased from 1.56±0.51 lt (53.4%) to 1.51±0.50 lt (53.2%). There was a statistically significant relationship between FEV1 change (decline / not) and gender, active smoking, regular inhaler device usage, exacerbation, hospitalization history in last year, presence of comorbidities and inhaler device adherence. FEV1 decline had positive correlation with the number of exacerbations in last year (r=0.432, p<0.001), and negative correlation with inhaler device usage score (r=-0.512, p<0.001). Multivariate regression analysis demonstrated that smoking status, number of exacerbations (per year) and inhaler therapy adherence were the factors that affect FEV1 decline in COPD patients (p=0.007, 0.001 ve 0.003, respectively).

 

CONCLUSION: Smoking is the major parameter that affects FEV1 value in COPD. Inhaler adherence may directly affect FEV1 change. Smoking cessation, preventing COPD exacerbations and increasing inhaler therapy adherence may decrease FEV1 declines of COPD patients in one-year period.

 

 

Keywords

• FEV1 decline,COPD,smoking

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