Factors That May Affect FEV1 Change Of COPD Patients In One-Year Period

Year 2020, Volume: 3 Issue: 1, 11 - 15, 30.04.2020

Muzaffer Onur Turan , Pakize Ayşe Turan Arzu Mirici

Abstract

INTRODUCTION: One of the hallmarks of COPD is the rate of
FEV1 decline. There are many factors that may affect pulmonary
parameters in a COPD patient. It was aimed to investigate the factors affecting FEV1 changes.

 

MATERIAL-METHODS: COPD outpatients who attended our pulmonology
clinic were included. Spirometric values and inhaler device usage performance
at that time and 12 months ago were compared.

 

RESULTS: Mean FEV1 values of 204 COPD patients
decreased from 1.56±0.51 lt (53.4%) to 1.51±0.50 lt (53.2%). There was a
statistically significant relationship between FEV1 change (decline / not) and
gender, active smoking, regular inhaler device usage, exacerbation, hospitalization
history in last year, presence of comorbidities and inhaler device adherence. FEV1
decline had positive correlation with the number of exacerbations in last year (r=0.432,
p<0.001), and negative correlation
with inhaler device usage score (r=-0.512, p<0.001). Multivariate regression analysis demonstrated
that smoking status, number of exacerbations (per year) and inhaler therapy
adherence were the factors that affect FEV1 decline in COPD patients (p=0.007, 0.001 ve 0.003, respectively).

 

CONCLUSION: Smoking is the major parameter that affects
FEV1 value in COPD. Inhaler adherence may directly affect FEV1 change. Smoking
cessation, preventing COPD exacerbations and increasing inhaler therapy
adherence may decrease FEV1 declines of COPD patients in one-year period.

 

 

Keywords

FEV1 decline, COPD, smoking

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