Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT

Volume: 1 Number: 3 September 1, 2014
  • Zafer Akan
  • Hasan Demiroglu
  • Ugur Avcibasi
  • Gokhan Oto
  • Hulya Ozdemir
  • Sabahattin Deniz
  • Ali Sadi Basak
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Medical Science and Discovery
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Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT

Abstract

Objective: Boron neutron capture therapy (BNCT) is an intensive research area for cancer researchers. Especially the side effects and inabilities of conventional therapies in some cases, directs researchers to find out a new cancer therapy methods such as BNCT. One of three important problem of BNCT is targeting of boron to tumor tissue. Borono Phenyl Alanine (BPA) and Borono Sodium Borocaptate (BSH) are already using in clinical studies as boron carriers. New boron carriers are searching for high yield boron accumulation in the tumor tissue. Methods: In this study, a novel 10B carrier was synthesized, ((2R)-4,5,6-trihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)boronic acid ( 10B-DG), for BNCT studies. 10Boric Acid and 2-Deoxy-d-Glucose was complexed ( 10B-DG) through a low-high pH reaction and yield of complexion was tested with FTIR ATR and Liquid Chromatography Mass Spectrometry (LC/MS). Results: Confirmation studies have been carried out by HPLC and chromatograms have confirmed that Borono-2-Deoxy-d-Glucose synthesized with % 80 yield. Conclusions: This compound appears to be an alternative boron carrier for BNCT applications

Keywords

References

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  6. Copyright © 2014 The Author(s); This is an open-access article distributed under the terms of the Creative Commons Attribution
  7. License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
  8. provided the original work is properly cited.

Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Zafer Akan This is me

Hasan Demiroglu This is me

Ugur Avcibasi This is me

Gokhan Oto This is me

Hulya Ozdemir This is me

Sabahattin Deniz This is me

Ali Sadi Basak This is me

Publication Date

September 1, 2014

Submission Date

December 26, 2014

Acceptance Date

-

Published in Issue

Year 2014 Volume: 1 Number: 3

DOI

https://doi.org/10.17546/msd.74442

IZ

https://izlik.org/JA44PE77FG

Cite

RIS / Bibtex
APA
Akan, Z., Demiroglu, H., Avcibasi, U., Oto, G., Ozdemir, H., Deniz, S., & Basak, A. S. (2014). Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT. Medical Science and Discovery, 1(3), 65-71. https://doi.org/10.17546/msd.74442
AMA
1.Akan Z, Demiroglu H, Avcibasi U, et al. Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT. Med Sci Discov. 2014;1(3):65-71. doi:10.17546/msd.74442
Chicago
Akan, Zafer, Hasan Demiroglu, Ugur Avcibasi, et al. 2014. “Complexion of Boric Acid With 2-Deoxy-D-Glucose (DG) As a Novel Boron Carrier for BNCT”. Medical Science and Discovery 1 (3): 65-71. https://doi.org/10.17546/msd.74442.
EndNote
Akan Z, Demiroglu H, Avcibasi U, Oto G, Ozdemir H, Deniz S, Basak AS (September 1, 2014) Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT. Medical Science and Discovery 1 3 65–71.
IEEE
[1]Z. Akan et al., “Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT”, Med Sci Discov, vol. 1, no. 3, pp. 65–71, Sept. 2014, doi: 10.17546/msd.74442.
ISNAD
Akan, Zafer - Demiroglu, Hasan - Avcibasi, Ugur - Oto, Gokhan - Ozdemir, Hulya - Deniz, Sabahattin - Basak, Ali Sadi. “Complexion of Boric Acid With 2-Deoxy-D-Glucose (DG) As a Novel Boron Carrier for BNCT”. Medical Science and Discovery 1/3 (September 1, 2014): 65-71. https://doi.org/10.17546/msd.74442.
JAMA
1.Akan Z, Demiroglu H, Avcibasi U, Oto G, Ozdemir H, Deniz S, Basak AS. Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT. Med Sci Discov. 2014;1:65–71.
MLA
Akan, Zafer, et al. “Complexion of Boric Acid With 2-Deoxy-D-Glucose (DG) As a Novel Boron Carrier for BNCT”. Medical Science and Discovery, vol. 1, no. 3, Sept. 2014, pp. 65-71, doi:10.17546/msd.74442.
Vancouver
1.Zafer Akan, Hasan Demiroglu, Ugur Avcibasi, Gokhan Oto, Hulya Ozdemir, Sabahattin Deniz, Ali Sadi Basak. Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT. Med Sci Discov. 2014 Sep. 1;1(3):65-71. doi:10.17546/msd.74442

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