Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT

Cilt: 1 Sayı: 3 1 Eylül 2014
  • Zafer Akan
  • Hasan Demiroglu
  • Ugur Avcibasi
  • Gokhan Oto
  • Hulya Ozdemir
  • Sabahattin Deniz
  • Ali Sadi Basak
Medical Science and Discovery Kapak
Medical Science and Discovery
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Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT

Abstract

Objective: Boron neutron capture therapy (BNCT) is an intensive research area for cancer researchers. Especially the side effects and inabilities of conventional therapies in some cases, directs researchers to find out a new cancer therapy methods such as BNCT. One of three important problem of BNCT is targeting of boron to tumor tissue. Borono Phenyl Alanine (BPA) and Borono Sodium Borocaptate (BSH) are already using in clinical studies as boron carriers. New boron carriers are searching for high yield boron accumulation in the tumor tissue. Methods: In this study, a novel 10B carrier was synthesized, ((2R)-4,5,6-trihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)boronic acid ( 10B-DG), for BNCT studies. 10Boric Acid and 2-Deoxy-d-Glucose was complexed ( 10B-DG) through a low-high pH reaction and yield of complexion was tested with FTIR ATR and Liquid Chromatography Mass Spectrometry (LC/MS). Results: Confirmation studies have been carried out by HPLC and chromatograms have confirmed that Borono-2-Deoxy-d-Glucose synthesized with % 80 yield. Conclusions: This compound appears to be an alternative boron carrier for BNCT applications

Keywords

Kaynakça

  1. Wick AN, Drury DR, Nakada HI, Wolfe JB. Localization
  2. of the primary metabolic block produced by 2
  3. deoxyglucose. The Journal of biological chemistry.
  4. Yu S. Review of F-FDG Synthesis and Quality Control. Biomedical
  5. 2006;2(4):e57. intervention journal.
  6. Copyright © 2014 The Author(s); This is an open-access article distributed under the terms of the Creative Commons Attribution
  7. License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
  8. provided the original work is properly cited.

Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

-

Yazarlar

Zafer Akan Bu kişi benim

Hasan Demiroglu Bu kişi benim

Ugur Avcibasi Bu kişi benim

Gokhan Oto Bu kişi benim

Hulya Ozdemir Bu kişi benim

Sabahattin Deniz Bu kişi benim

Ali Sadi Basak Bu kişi benim

Yayımlanma Tarihi

1 Eylül 2014

Gönderilme Tarihi

26 Aralık 2014

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2014 Cilt: 1 Sayı: 3

DOI

https://doi.org/10.17546/msd.74442

IZ

https://izlik.org/JA44PE77FG

Kaynak Göster

RIS / Bibtex
APA
Akan, Z., Demiroglu, H., Avcibasi, U., Oto, G., Ozdemir, H., Deniz, S., & Basak, A. S. (2014). Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT. Medical Science and Discovery, 1(3), 65-71. https://doi.org/10.17546/msd.74442
AMA
1.Akan Z, Demiroglu H, Avcibasi U, vd. Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT. Med Sci Discov. 2014;1(3):65-71. doi:10.17546/msd.74442
Chicago
Akan, Zafer, Hasan Demiroglu, Ugur Avcibasi, vd. 2014. “Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT”. Medical Science and Discovery 1 (3): 65-71. https://doi.org/10.17546/msd.74442.
EndNote
Akan Z, Demiroglu H, Avcibasi U, Oto G, Ozdemir H, Deniz S, Basak AS (01 Eylül 2014) Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT. Medical Science and Discovery 1 3 65–71.
IEEE
[1]Z. Akan vd., “Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT”, Med Sci Discov, c. 1, sy 3, ss. 65–71, Eyl. 2014, doi: 10.17546/msd.74442.
ISNAD
Akan, Zafer - Demiroglu, Hasan - Avcibasi, Ugur - Oto, Gokhan - Ozdemir, Hulya - Deniz, Sabahattin - Basak, Ali Sadi. “Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT”. Medical Science and Discovery 1/3 (01 Eylül 2014): 65-71. https://doi.org/10.17546/msd.74442.
JAMA
1.Akan Z, Demiroglu H, Avcibasi U, Oto G, Ozdemir H, Deniz S, Basak AS. Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT. Med Sci Discov. 2014;1:65–71.
MLA
Akan, Zafer, vd. “Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT”. Medical Science and Discovery, c. 1, sy 3, Eylül 2014, ss. 65-71, doi:10.17546/msd.74442.
Vancouver
1.Zafer Akan, Hasan Demiroglu, Ugur Avcibasi, Gokhan Oto, Hulya Ozdemir, Sabahattin Deniz, Ali Sadi Basak. Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT. Med Sci Discov. 01 Eylül 2014;1(3):65-71. doi:10.17546/msd.74442

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Synthesis of Borono Fluoro Deoxy D glucose (10B-18F-DG) as Boron carrier for Boron neutron capture therapy BNCT

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https://doi.org/10.17546/msd.331654