BibTex RIS Kaynak Göster

Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT

Yıl 2014, Cilt: 1 Sayı: 3, 65 - 71, 01.09.2014

Zafer Akan Hasan Demiroglu Ugur Avcibasi Gokhan Oto Hulya Ozdemir Sabahattin Deniz Ali Sadi Basak

https://doi.org/10.17546/msd.74442
https://izlik.org/JA44PE77FG

Öz

Objective: Boron neutron capture therapy (BNCT) is an intensive research area for cancer researchers. Especially the side effects and inabilities of conventional therapies in some cases, directs researchers to find out a new cancer therapy methods such as BNCT. One of three important problem of BNCT is targeting of boron to tumor tissue. Borono Phenyl Alanine (BPA) and Borono Sodium Borocaptate (BSH) are already using in clinical studies as boron carriers. New boron carriers are searching for high yield boron accumulation in the tumor tissue. Methods: In this study, a novel 10B carrier was synthesized, ((2R)-4,5,6-trihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)boronic acid ( 10B-DG), for BNCT studies. 10Boric Acid and 2-Deoxy-d-Glucose was complexed ( 10B-DG) through a low-high pH reaction and yield of complexion was tested with FTIR ATR and Liquid Chromatography Mass Spectrometry (LC/MS). Results: Confirmation studies have been carried out by HPLC and chromatograms have confirmed that Borono-2-Deoxy-d-Glucose synthesized with % 80 yield. Conclusions: This compound appears to be an alternative boron carrier for BNCT applications

Anahtar Kelimeler

((2R)-4 5 6-trihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)boronic acid 10B-DG BDG BNCT HPLC FTIR-ATR LC-MS

Kaynakça

  • Wick AN, Drury DR, Nakada HI, Wolfe JB. Localization
  • of the primary metabolic block produced by 2
  • deoxyglucose. The Journal of biological chemistry.
  • Yu S. Review of F-FDG Synthesis and Quality Control. Biomedical
  • 2006;2(4):e57. intervention journal.
  • Copyright © 2014 The Author(s); This is an open-access article distributed under the terms of the Creative Commons Attribution
  • License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
  • provided the original work is properly cited.

Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT

Yıl 2014, Cilt: 1 Sayı: 3, 65 - 71, 01.09.2014

Zafer Akan Hasan Demiroglu Ugur Avcibasi Gokhan Oto Hulya Ozdemir Sabahattin Deniz Ali Sadi Basak

https://doi.org/10.17546/msd.74442
https://izlik.org/JA44PE77FG

Öz

Kaynakça

  • Wick AN, Drury DR, Nakada HI, Wolfe JB. Localization
  • of the primary metabolic block produced by 2
  • deoxyglucose. The Journal of biological chemistry.
  • Yu S. Review of F-FDG Synthesis and Quality Control. Biomedical
  • 2006;2(4):e57. intervention journal.
  • Copyright © 2014 The Author(s); This is an open-access article distributed under the terms of the Creative Commons Attribution
  • License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
  • provided the original work is properly cited.
Toplam 8 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Yazarlar

Zafer Akan Bu kişi benim

Hasan Demiroglu Bu kişi benim

Ugur Avcibasi Bu kişi benim

Gokhan Oto Bu kişi benim

Hulya Ozdemir Bu kişi benim

Sabahattin Deniz Bu kişi benim

Ali Sadi Basak Bu kişi benim

Yayımlanma Tarihi 1 Eylül 2014
DOI https://doi.org/10.17546/msd.74442
IZ https://izlik.org/JA44PE77FG
Yayımlandığı Sayı Yıl 2014 Cilt: 1 Sayı: 3

Kaynak Göster

APA Akan, Z., Demiroglu, H., Avcibasi, U., Oto, G., Ozdemir, H., Deniz, S., & Basak, A. S. (2014). Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT. Medical Science and Discovery, 1(3), 65-71. https://doi.org/10.17546/msd.74442
AMA 1.Akan Z, Demiroglu H, Avcibasi U, vd. Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT. Med Sci Discov. 2014;1(3):65-71. doi:10.17546/msd.74442
Chicago Akan, Zafer, Hasan Demiroglu, Ugur Avcibasi, vd. 2014. “Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT”. Medical Science and Discovery 1 (3): 65-71. https://doi.org/10.17546/msd.74442.
EndNote Akan Z, Demiroglu H, Avcibasi U, Oto G, Ozdemir H, Deniz S, Basak AS (01 Eylül 2014) Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT. Medical Science and Discovery 1 3 65–71.
IEEE [1]Z. Akan vd., “Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT”, Med Sci Discov, c. 1, sy 3, ss. 65–71, Eyl. 2014, doi: 10.17546/msd.74442.
ISNAD Akan, Zafer - Demiroglu, Hasan - Avcibasi, Ugur - Oto, Gokhan - Ozdemir, Hulya - Deniz, Sabahattin - Basak, Ali Sadi. “Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT”. Medical Science and Discovery 1/3 (01 Eylül 2014): 65-71. https://doi.org/10.17546/msd.74442.
JAMA 1.Akan Z, Demiroglu H, Avcibasi U, Oto G, Ozdemir H, Deniz S, Basak AS. Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT. Med Sci Discov. 2014;1:65–71.
MLA Akan, Zafer, vd. “Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT”. Medical Science and Discovery, c. 1, sy 3, Eylül 2014, ss. 65-71, doi:10.17546/msd.74442.
Vancouver 1.Akan Z, Demiroglu H, Avcibasi U, Oto G, Ozdemir H, Deniz S, vd. Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT. Med Sci Discov [Internet]. 01 Eylül 2014;1(3):65-71. Erişim adresi: https://izlik.org/JA44PE77FG

Cited By

Synthesis of Borono Fluoro Deoxy D glucose (10B-18F-DG) as Boron carrier for Boron neutron capture therapy BNCT
Medical Science and Discovery
Zafer AKAN
https://doi.org/10.17546/msd.331654