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Relationship Between HDLc, NonHDLc/ HDLc Ratio and Gilbert's Syndrome

Year 2015, , 334 - 338, 01.09.2015

Salim Ozenc , Hakan Sarlak Sinan Iscen

https://doi.org/10.17546/msd.27077

Abstract

Objective: We investigated the relationship between HDL-cholesterol levels that is indirect marker of ApoA-I production in liver, Non-HDL-cholesterol that is indirect marker of ApoB and GS

Methods: HDLc, NonHDLc/ HDLc Ratio levels were investigated in subjects with GS (n=148) and compared to healthy controls (n=148).

Results: Age and BMI distributions were similar between the two groups.

HDLc levels were lower in GS than the healthy controls (p=0.012). However, TC, Non-HDLc, Non-HDLc/HDLc levels were higher in GS than the healthy controls (p=0.002, p=0.001, p<0.001, respectively). In correlation analysis, UB were negatively mildly correlated with HDLc (r=−0.191, p=0.001) and positively correlated with TC (r=0.436, p<0.001), Non-HDLc (r=0.511, p<0.001) and Non-HDLc/HDLc (r=0.512, p<0.001) in the whole group.

Conclusions: The contrary of previously studies, we would like to suggest that bilirubin is a only antioxidant agent that protects from cardiovascular disease, but not physiological hypolipidemic agent.

Keywords

Gilbert's syndrome(GS) Unconjugated hyperbilirubinemia (UB) HDL cholesterol Non-HDL-cholesterol NonHDLc/HDLc ratio.

References

  • Fertrin KY, Goncalves MS, Saad ST, Costa FF. Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil. Am J Med Genet 2002;108:117–9.
  • Hirschfield GM, Alexander GJ. Gilbert's syndrome: an overview for clinical biochemists. Ann Clin Biochem 2006;43:340–3.
  • Vitek L, Jirsa M, Brodanova M, Kalab M, Marecek Z, Danzig V, et al. Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels. Atherosclerosis 2002;160:449–56.
  • Schwertner HA. Bilirubin concentration, UGT1A1*28 polymorphism, and coronary artery disease. Clin Chem 2003;49:1039–40.
  • Gordon DJ, Rifkind BM. High-density lipoprotein--the clinical implications of recent studies. N Engl J Med 1989; 321:1311.
  • Lamprea-Montealegre JA, Sharrett AR, Matsushita K, Selvin E, Szklo M, Astor BC. Chronic kidney disease, lipids and apolipoproteins, and coronary heart disease: the ARIC Study. Atherosclerosis 2014;234:42e6.
  • Holman RR, Coleman RL, Shine BS, Stevens RJ. Non-HDL cholesterol is less informative than the total-to-HDL cholesterol ratio in predicting cardiovascular risk in type 2 diabetes. Diabetes Care 2005;28:1796e7.
  • Kim SW, Jee JH, Kim HJ, Jin S, Suh S, Bae JC, et al. Non-HDL-cholesterol/HDL-cholesterol is a better predictor of metabolic syndrome and insulin resistance than apolipoprotein B/apolipoprotein A1. Int J Cardiol 2013;168:2678e83.
  • Friedewald WT, Levy R, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499–502.
  • Schwertner HA, Jackson WG, Tolan G. Association of low serum concentration of bilirubin with increased risk of coronary artery disease. Clin Chem 1994;40:18–23.
  • Hopkins PN, Wu LL, Hunt SC, James BC, Vincent GM, William RR. Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease. Arterioscler Thromb Vasc Biol 1996;16:250–5.
  • Očadlík I, Hlinštáková S, Oravec S. Relationship between unconjugated hyperbilirubinemia and lipoprotein spectrum. Neuro Endocrinol Lett. 2011;32(3):360-4.
  • Bulmer AC, Verkade HJ, Wagner KH. Prog Lipid Res. 2013 Apr;52(2):193-205. doi: 10.1016/j.plipres.2012.11.001. Epub 2012 Nov 29.Bilirubin and beyond: a review of lipid status in Gilbert's syndrome and its relevance to cardiovascular disease protection.
  • Effects of Gilbert’s Syndrome on Lipid Profile, Levels of Serum Uric Acid, Glucose and Insulin Resistance. Cüre M.C , Cüre E. , Kırbaş A, Yüce S. , Ertürk A. Cukurova Medical Journal 2014;39(3):443-450.
  • Tapan S, Karadurmus N, Dogru T, Ercin CN, Tasci I, Bilgi C, et al. Decreased small dense LDL levels in Gilbert's syndrome. Clin Biochem 2011;44:300-3.
  • Bilirubin and beyond: A review of lipid status in Gilbert’s syndrome and its relevance to cardiovascular disease protection. A.C. Bulmer, H.J. Verkade, K.-H. Wagner. Prog Lipid Res. 2013 Apr;52(2):193-205. doi: 10.1016/j.plipres.2012.11.001. Epub 2012 Nov 29.

Relationship among the HDLc, NonHDLc/ HDLc ratio and Gilbert's Syndrome

Year 2015, , 334 - 338, 01.09.2015

Salim Ozenc , Hakan Sarlak Sinan Iscen

https://doi.org/10.17546/msd.27077

Abstract

References

  • Fertrin KY, Goncalves MS, Saad ST, Costa FF. Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil. Am J Med Genet 2002;108:117–9.
  • Hirschfield GM, Alexander GJ. Gilbert's syndrome: an overview for clinical biochemists. Ann Clin Biochem 2006;43:340–3.
  • Vitek L, Jirsa M, Brodanova M, Kalab M, Marecek Z, Danzig V, et al. Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels. Atherosclerosis 2002;160:449–56.
  • Schwertner HA. Bilirubin concentration, UGT1A1*28 polymorphism, and coronary artery disease. Clin Chem 2003;49:1039–40.
  • Gordon DJ, Rifkind BM. High-density lipoprotein--the clinical implications of recent studies. N Engl J Med 1989; 321:1311.
  • Lamprea-Montealegre JA, Sharrett AR, Matsushita K, Selvin E, Szklo M, Astor BC. Chronic kidney disease, lipids and apolipoproteins, and coronary heart disease: the ARIC Study. Atherosclerosis 2014;234:42e6.
  • Holman RR, Coleman RL, Shine BS, Stevens RJ. Non-HDL cholesterol is less informative than the total-to-HDL cholesterol ratio in predicting cardiovascular risk in type 2 diabetes. Diabetes Care 2005;28:1796e7.
  • Kim SW, Jee JH, Kim HJ, Jin S, Suh S, Bae JC, et al. Non-HDL-cholesterol/HDL-cholesterol is a better predictor of metabolic syndrome and insulin resistance than apolipoprotein B/apolipoprotein A1. Int J Cardiol 2013;168:2678e83.
  • Friedewald WT, Levy R, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499–502.
  • Schwertner HA, Jackson WG, Tolan G. Association of low serum concentration of bilirubin with increased risk of coronary artery disease. Clin Chem 1994;40:18–23.
  • Hopkins PN, Wu LL, Hunt SC, James BC, Vincent GM, William RR. Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease. Arterioscler Thromb Vasc Biol 1996;16:250–5.
  • Očadlík I, Hlinštáková S, Oravec S. Relationship between unconjugated hyperbilirubinemia and lipoprotein spectrum. Neuro Endocrinol Lett. 2011;32(3):360-4.
  • Bulmer AC, Verkade HJ, Wagner KH. Prog Lipid Res. 2013 Apr;52(2):193-205. doi: 10.1016/j.plipres.2012.11.001. Epub 2012 Nov 29.Bilirubin and beyond: a review of lipid status in Gilbert's syndrome and its relevance to cardiovascular disease protection.
  • Effects of Gilbert’s Syndrome on Lipid Profile, Levels of Serum Uric Acid, Glucose and Insulin Resistance. Cüre M.C , Cüre E. , Kırbaş A, Yüce S. , Ertürk A. Cukurova Medical Journal 2014;39(3):443-450.
  • Tapan S, Karadurmus N, Dogru T, Ercin CN, Tasci I, Bilgi C, et al. Decreased small dense LDL levels in Gilbert's syndrome. Clin Biochem 2011;44:300-3.
  • Bilirubin and beyond: A review of lipid status in Gilbert’s syndrome and its relevance to cardiovascular disease protection. A.C. Bulmer, H.J. Verkade, K.-H. Wagner. Prog Lipid Res. 2013 Apr;52(2):193-205. doi: 10.1016/j.plipres.2012.11.001. Epub 2012 Nov 29.
There are 16 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Article
Authors

Salim Ozenc

Hakan Sarlak This is me

Sinan Iscen

Publication Date September 1, 2015
Published in Issue Year 2015

Cite

APA Ozenc, S., Sarlak, H., & Iscen, S. (2015). Relationship Between HDLc, NonHDLc/ HDLc Ratio and Gilbert’s Syndrome. Medical Science and Discovery, 2(6), 334-338. https://doi.org/10.17546/msd.27077
AMA Ozenc S, Sarlak H, Iscen S. Relationship Between HDLc, NonHDLc/ HDLc Ratio and Gilbert’s Syndrome. Med Sci Discov. December 2015;2(6):334-338. doi:10.17546/msd.27077
Chicago Ozenc, Salim, Hakan Sarlak, and Sinan Iscen. “Relationship Between HDLc, NonHDLc/ HDLc Ratio and Gilbert’s Syndrome”. Medical Science and Discovery 2, no. 6 (December 2015): 334-38. https://doi.org/10.17546/msd.27077.
EndNote Ozenc S, Sarlak H, Iscen S (December 1, 2015) Relationship Between HDLc, NonHDLc/ HDLc Ratio and Gilbert’s Syndrome. Medical Science and Discovery 2 6 334–338.
IEEE S. Ozenc, H. Sarlak, and S. Iscen, “Relationship Between HDLc, NonHDLc/ HDLc Ratio and Gilbert’s Syndrome”, Med Sci Discov, vol. 2, no. 6, pp. 334–338, 2015, doi: 10.17546/msd.27077.
ISNAD Ozenc, Salim et al. “Relationship Between HDLc, NonHDLc/ HDLc Ratio and Gilbert’s Syndrome”. Medical Science and Discovery 2/6 (December 2015), 334-338. https://doi.org/10.17546/msd.27077.
JAMA Ozenc S, Sarlak H, Iscen S. Relationship Between HDLc, NonHDLc/ HDLc Ratio and Gilbert’s Syndrome. Med Sci Discov. 2015;2:334–338.
MLA Ozenc, Salim et al. “Relationship Between HDLc, NonHDLc/ HDLc Ratio and Gilbert’s Syndrome”. Medical Science and Discovery, vol. 2, no. 6, 2015, pp. 334-8, doi:10.17546/msd.27077.
Vancouver Ozenc S, Sarlak H, Iscen S. Relationship Between HDLc, NonHDLc/ HDLc Ratio and Gilbert’s Syndrome. Med Sci Discov. 2015;2(6):334-8.