Relationship Between HDLc, NonHDLc/ HDLc Ratio and Gilbert's Syndrome

Abstract

Objective: We investigated the relationship between HDL-cholesterol levels that is indirect marker of ApoA-I production in liver, Non-HDL-cholesterol that is indirect marker of ApoB and GS

Methods: HDLc, NonHDLc/ HDLc Ratio levels were investigated in subjects with GS (n=148) and compared to healthy controls (n=148).

Results: Age and BMI distributions were similar between the two groups.

HDLc levels were lower in GS than the healthy controls (p=0.012). However, TC, Non-HDLc, Non-HDLc/HDLc levels were higher in GS than the healthy controls (p=0.002, p=0.001, p<0.001, respectively). In correlation analysis, UB were negatively mildly correlated with HDLc (r=−0.191, p=0.001) and positively correlated with TC (r=0.436, p<0.001), Non-HDLc (r=0.511, p<0.001) and Non-HDLc/HDLc (r=0.512, p<0.001) in the whole group.

Conclusions: The contrary of previously studies, we would like to suggest that bilirubin is a only antioxidant agent that protects from cardiovascular disease, but not physiological hypolipidemic agent.

Keywords

• Gilbert's syndrome(GS), Unconjugated hyperbilirubinemia (UB), HDL cholesterol, Non-HDL-cholesterol ,NonHDLc/HDLc ratio.

Relationship among the HDLc, NonHDLc/ HDLc ratio and Gilbert's Syndrome

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