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Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT

Year 2014, Volume: 1 Issue: 3, 65 - 71, 01.09.2014

Zafer Akan Hasan Demiroglu Ugur Avcibasi Gokhan Oto Hulya Ozdemir Sabahattin Deniz Ali Sadi Basak

https://doi.org/10.17546/msd.74442
Cited By: 1

Abstract

Objective: Boron neutron capture therapy (BNCT) is an intensive research area for cancer researchers. Especially the side effects and inabilities of conventional therapies in some cases, directs researchers to find out a new cancer therapy methods such as BNCT. One of three important problem of BNCT is targeting of boron to tumor tissue. Borono Phenyl Alanine (BPA) and Borono Sodium Borocaptate (BSH) are already using in clinical studies as boron carriers. New boron carriers are searching for high yield boron accumulation in the tumor tissue. Methods: In this study, a novel 10B carrier was synthesized, ((2R)-4,5,6-trihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)boronic acid ( 10B-DG), for BNCT studies. 10Boric Acid and 2-Deoxy-d-Glucose was complexed ( 10B-DG) through a low-high pH reaction and yield of complexion was tested with FTIR ATR and Liquid Chromatography Mass Spectrometry (LC/MS). Results: Confirmation studies have been carried out by HPLC and chromatograms have confirmed that Borono-2-Deoxy-d-Glucose synthesized with % 80 yield. Conclusions: This compound appears to be an alternative boron carrier for BNCT applications

Keywords

((2R)-4 5 6-trihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)boronic acid 10B-DG BDG BNCT HPLC FTIR-ATR LC-MS

References

  • Wick AN, Drury DR, Nakada HI, Wolfe JB. Localization
  • of the primary metabolic block produced by 2
  • deoxyglucose. The Journal of biological chemistry.
  • Yu S. Review of F-FDG Synthesis and Quality Control. Biomedical
  • 2006;2(4):e57. intervention journal.
  • Copyright © 2014 The Author(s); This is an open-access article distributed under the terms of the Creative Commons Attribution
  • License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
  • provided the original work is properly cited.

Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT

Year 2014, Volume: 1 Issue: 3, 65 - 71, 01.09.2014

Zafer Akan Hasan Demiroglu Ugur Avcibasi Gokhan Oto Hulya Ozdemir Sabahattin Deniz Ali Sadi Basak

https://doi.org/10.17546/msd.74442
Cited By: 1

Abstract

References

  • Wick AN, Drury DR, Nakada HI, Wolfe JB. Localization
  • of the primary metabolic block produced by 2
  • deoxyglucose. The Journal of biological chemistry.
  • Yu S. Review of F-FDG Synthesis and Quality Control. Biomedical
  • 2006;2(4):e57. intervention journal.
  • Copyright © 2014 The Author(s); This is an open-access article distributed under the terms of the Creative Commons Attribution
  • License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
  • provided the original work is properly cited.
There are 8 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Zafer Akan This is me

Hasan Demiroglu This is me

Ugur Avcibasi This is me

Gokhan Oto This is me

Hulya Ozdemir This is me

Sabahattin Deniz This is me

Ali Sadi Basak This is me

Publication Date September 1, 2014
Published in Issue Year 2014 Volume: 1 Issue: 3

Cite

APA Akan, Z., Demiroglu, H., Avcibasi, U., Oto, G., et al. (2014). Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT. Medical Science and Discovery, 1(3), 65-71. https://doi.org/10.17546/msd.74442
AMA Akan Z, Demiroglu H, Avcibasi U, Oto G, Ozdemir H, Deniz S, Basak AS. Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT. Med Sci Discov. September 2014;1(3):65-71. doi:10.17546/msd.74442
Chicago Akan, Zafer, Hasan Demiroglu, Ugur Avcibasi, Gokhan Oto, Hulya Ozdemir, Sabahattin Deniz, and Ali Sadi Basak. “Complexion of Boric Acid With 2-Deoxy-D-Glucose (DG) As a Novel Boron Carrier for BNCT”. Medical Science and Discovery 1, no. 3 (September 2014): 65-71. https://doi.org/10.17546/msd.74442.
EndNote Akan Z, Demiroglu H, Avcibasi U, Oto G, Ozdemir H, Deniz S, Basak AS (September 1, 2014) Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT. Medical Science and Discovery 1 3 65–71.
IEEE Z. Akan, H. Demiroglu, U. Avcibasi, G. Oto, H. Ozdemir, S. Deniz, and A. S. Basak, “Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT”, Med Sci Discov, vol. 1, no. 3, pp. 65–71, 2014, doi: 10.17546/msd.74442.
ISNAD Akan, Zafer et al. “Complexion of Boric Acid With 2-Deoxy-D-Glucose (DG) As a Novel Boron Carrier for BNCT”. Medical Science and Discovery 1/3 (September 2014), 65-71. https://doi.org/10.17546/msd.74442.
JAMA Akan Z, Demiroglu H, Avcibasi U, Oto G, Ozdemir H, Deniz S, Basak AS. Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT. Med Sci Discov. 2014;1:65–71.
MLA Akan, Zafer et al. “Complexion of Boric Acid With 2-Deoxy-D-Glucose (DG) As a Novel Boron Carrier for BNCT”. Medical Science and Discovery, vol. 1, no. 3, 2014, pp. 65-71, doi:10.17546/msd.74442.
Vancouver Akan Z, Demiroglu H, Avcibasi U, Oto G, Ozdemir H, Deniz S, Basak AS. Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT. Med Sci Discov. 2014;1(3):65-71.

Cited By

Synthesis of Borono Fluoro Deoxy D glucose (10B-18F-DG) as Boron carrier for Boron neutron capture therapy BNCT
Medical Science and Discovery
Zafer AKAN
https://doi.org/10.17546/msd.331654
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