Bovine Respiratory Disease Complex

Abstract

Bovine respiratory disease can be caused by multifactorial causes including stress, viral, bacterial, environmental and animal factors. Among the infectious agents, while viral agents are Herpes virus-1, Parainfluenza virus 3, Bovine respiratory syncytial virus, Bovine viral diarrhea virüs, bacterial agents are Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Myocoplasma bovis. Good nutrition, vaccination against diseases, reducing stress factors and regulating air circulation are important factors in reducing the risk of respiratory diseases in cattle. Tetracycline, fluoroquinolone, ceftiofur and macrolide antibiotics such as tilmicosin and tulathromycin are used in the treatment. In addition, nonsteroidal and steroid-derived anti-inflammatory drugs are used in supportive therapy.

Keywords

• Bovine respiratory disease complex
• pneumonia
• respiratory pathogens

Sığırların Solunum Sistemi Hastalığı Kompleksi

Abstract

Sığırların solunum sistemi hastalığı stres, viral, bakteriyel, çevresel ve hayvana ait faktörleri kapsayan multifaktöriyel sebeplerden oluşabilmektedir. Enfeksiyon etkenlerinden viral etkenleri Herpes virüs-1, Parainflüenza virüs 3, Bovine respiratuar sinsityal virüs, Bovine viral diyare virüs oluştururken, bakteriyel etkenleri Mannheimia haemolytica, Pasteurella multocida, Histophilus somni ve Mycoplasma bovis oluşturmaktadır. İyi besleme, hastalıklara karşı aşılama, stres faktörlerini azaltma ve hava sirkülasyonunu düzenleme sığırlarda solunum sistemi hastalıkları riskini azaltmada önemli faktörlerdir. Tedavide daha çok tetrasiklin, florokinolon, seftiofur, tilmikosin ve tulatromisin gibi makrolid antibiyotikler kullanılmaktadır. Ayrıca destekleyici tedavide nonsteroid ve streoid türevli antienflamatuvar ilaçlar da kullanılmaktadır.

Keywords

• Pnömoni
• sığırların solunum sistemi hastalığı kompleksi
• Solunum patojenleri

References

1. Edwards T.A. Control methods for bovine respiratory disease for feedlot cattle, Veterinary Clinics of North America: Food Animal Practice, 26 273-284, 2010.
2. Guterbock W.M. The impact of BRD: The current dairy experience, Animal Health Research Reviews, 15 130134, 2014.
3. Wikse S.E. Feedlot cattle pneumonia, Veterinary Clinics of North America: Food Animal Practice, 1 289-310, 1985.
4. Adams E.A., Buczinski S. Short communication: Ultrasonographic assessment of lung consolidation postweaning and survival to the first lactation in dairy heifers, Journal of Dairy Science, 99 1465-1470, 2016.
5. McGill J.L., Sacco R.E. The immunology of bovine respiratory disease: Recent advancements, Veterinary Clinics of North America: Food Animal Practice, 36 333348, 2020.
6. Mosier D. Review of BRD pathogenesis: The old and the new, Animal Health Research Reviews, 15 166-168, 2014.
7. Ackermann M.R., Derscheid R., Roth J.A. Innate immunology of bovine respiratory disease, Veterinary Clinics of North America: Food Animal Practice, 26 215228, 2010.
8. Coumou D., Rahmstorf S.A decade of weather extremes, Nature Climate Change, 2 491-496, 2012.

9. Grissett G.P., White B.J., Larson R.L. Structured literature review of responses of cattle to viral and bacterial pathogens causing bovine respiratory disease complex, Journal of Veterinary Internal Medicine, 29 770-780, 2015.
10. Panciera R.J., Confer A.W. Pathogenesis and pathology of bovine pneumonia, Veterinary Clinics of North America: Food Animal Practice, 26 191-214, 2010.
11. Jones C., Chowdhury S.A review of the biology of bovine herpesvirus type 1 (BHV-1), its role as a cofactor in the bovine respiratory disease complex and development of improved vaccines, Animal Health Research Reviews, 8 187-205, 2007.
12. Bryant T.C., Rogers K.C., Stone N.D., Miles D.G. Effect of viral respiratory vaccine treatment on performance, health and carcass traits of auction-origin feeder steers, The Bovine Practitioner, 42 98-103, 2008.
13. Raaperi K., Orro T., Viltrop A. Epidemiology and control of bovine herpesvirus 1 infection in Europe, The Veterinary Journal, 201 249-256, 2014.
14. Nettleton P., Russell G. Update on infectious bovine rhinotracheitis, In Pract, 39 255-272, 2017.
15. Zajac M.P.D.M., Ladelfa M.F., Kotsias F., Muylkens B., Thiry J., Thiry E., Romera S.A. Biology of bovine herpesvirus 5, The Veterinary Journal, 184 138-145, 2010.
16. Gratzek J.B., Peter C.P., Ramsey F.K. Isolation and characterization of a strain of infectious bovine rhinotracheitis virus associated with enteritis in cattle: Isolation, serologic characterization, and induction of the experimental disease, American Journal Veterinary Research, 27 1567-1572, 1966.
17. Nandi S., Kumar M., Manohar M., Chauhan R.S. Bovine herpes virus infections in cattle, Animal Health Research Reviews, 10 85-98, 2009.
18. Smith D.B., Meyers G., Bukh J., Gould E.A., Monath T., Scott Muerhoff A., Pletnev A., Rico-Hesse R., Stapleton J.T., Simmonds P., Becher P. Proposed revision to the taxonomy of the genus pestivirus, family flaviviridae, The Journal of General Virology, 98 2106-2112, 2017.
19. Mishra N., Rajukumar K., Pateriya A., Kumar M., Dubey P., Behera S.P., Verma A., Bhardwaj P., Kulkarni D.D., Vijaykrishna D., Reddy N.D. Identification and molecular characterization of novel and divergent Hobilike pestiviruses from naturally infected cattle in India, Veterinary Microbiology, 174 239-246, 2014.
20. Yesilbag K., Alpay G., Becher P. Variability and global distribution of subgenotypes of bovine viral diarrhea virus, Viruses, 9:6 128, 2017.
21. Ammari M., McCarthy F.M., Nanduri B., Pinchuk L.M. Analysis of bovine viral diarrhea viruses-infected monocytes: Identification of cytopathic and noncytopathic biotype differences, BMC Bioinformatics, 11:6 1-13, 2010.
22. Richter V., Lebl K., Baumgartner W., Obritzhauser W., Kasbohrer A., Pinior B. A systematic worldwide review of the direct monetary losses in cattle due to bovine viral diarrhoea virus infection, The Veterinary Journal, 220 8087, 2017.
23. Lanyon S.R., Hill F.I., Reichel M.P., Brownlie J. Bovine viral diarrhoea: Pathogenesis and diagnosis, The Veterinary Journal, 199 201-209, 2014.
24. Givens M.D., Marley M.S., Jones C.A., Ensley D.T., Galik P.K., Zhang Y., Riddell K.P., Joiner K.S., Brodersen B.W., Rodning S.P. Protective effects against abortion and fetal infection following exposure to bovine viral diarrhea virus and bovine herpesvirus 1 during pregnancy in beef heifers that received two doses of a multivalent modified-live virus vaccine prior to breeding, Journal of the American Veterinary Medical Association, 241 484-495, 2012.
25. Falkenberg S.M., Bauermann F.V., Ridpath J.F. Characterization of thymus-associated lymphoid depletion in bovine calves acutely or persistently infected with bovine viral diarrhea virus 1, bovine viral diarrhea virus 2 or Hobi-like pestivirus, Archives of Virology, 162 3473-3480, 2017.
26. Duffell S.J., Harkness J.W. Bovine virus diarrhoeamucosal disease infection in cattle, The Veterinary Record, 117 240-245, 1985.
27. Sprecher D.J., Baker J.C., Holland R.E., Yamini B. An outbreak of fetal and neonatal losses associated with the diagnosis of bovine viral diarrhea virus, Theriogenology, 36 597-606, 1991.
28. Kahrs R.F. Viral diseases of cattle, Ames, Iowa State University Press, 1981.
29. Baker J.C. The clinical manifestations of bovine viral diarrhea infection, Veterinary Clinics of North America: Food Animal Practice, 11 425-445, 1995.
30. Taghipour B.T., Khodakaram T.A., Mousakhani F., Nekouie J.O.A. Occurrence of congenital tremor in holstein calves due to infection with BVDV in two industrial dairies from Tehran and Kerman Provinces (case report), Scientific-Research Iranian Veterinary Journal, 7 92-96, 2011.
31. Peterhans E., Jungi T.W., Schweizer M. BVDV and innate immunity, Biologicals, 31 107-112, 2003.
32. Scharnbock B., Roch F.F., Richter V., Funke C., Firth C. L., Obritzhauser W., Baumgartner W., Kasbohrer A., Pinior B. A meta-analysis of bovine viral diarrhoea virus (BVDV) prevalences in the global cattle population, Scientific Reports, 8:1 1-15, 2018.
33. Chase C.C., Thakur N., Darweesh M.F., Morarie-Kane S.E., Rajput M.K. Immune response to bovine viral diarrhea virus-looking at newly defined targets, Animal Health Research Reviews, 16 4-14, 2015.
34. Leal E., Liu C., Zhao Z., Deng Y., Villanova F., Liang L., Li J., Cui S. Isolation of a divergent strain of bovine parainfluenza virus type 3 (BPIV3) infecting cattle in China, Viruses, 11:6 489, 2019.
35. Ellis J.A. Bovine parainfluenza-3 virus, Veterinary Clinics: Food Animal Practice, 26 575-593, 2010.
36. Sobhy N.M., Mor S.K., Bastawecy I.M., Fakhry H.M., Youssef C.R.B., Goyal S.M. Surveillance, isolation and complete genome sequence of bovine parainfluenza virus type 3 in Egyptian cattle, International Journal of Veterinary Science and Medicine, 5 8-13, 2017.
37. Irsik M., Langemeier M., Schroeder T., Spire M., Roder J.D. Estimating the effects of animal health on the performance of feedlot cattle, The Bovine Practitioner, 40 65-74, 2006.
38. Maidana S.S., Lomonaco P.M., Combessies G., Craig M.I., Diodati J., Rodriguez D., Parreno V., Zabal O., Konrad J.L., Crudelli G., Mauroy A., Thiry E., Romera S.A. Isolation and characterization of bovine parainfluenza virus type 3 from water buffaloes (Bubalus bubalis) in Argentina, BMC Veterinary Research, 8:1 83, 2012.
39. Neill J.D., Ridpath J.F., Valayudhan B.T. Identification and genome characterization of genotype B and genotype C bovine parainfluenza type 3 viruses isolated in the United States, BMC Veterinary Research, 11 112, 2015.
40. Newcomer B.W., Neill J.D., Galik P.K., Riddell K.P., Zhang Y., Passler T., Velayudhan B.T., Walz P.H. Serologic survey for antibodies against three genotypes of bovine parainfluenza 3 virus in unvaccinated ungulates in Alabama, American Journal of Veterinary Research, 78 239-243, 2017.
41. Jim K. Impact of bovine respiratory disease (BRD) from the perspective of the canadian beef producer, Animal Health Research Reviews, 10 109-110, 2009.
42. Lebedev M., McEligot H.A., Mutua V.N., Walsh P., Carvallo Chaigneau F.R., Gershwin L.J. Analysis of lung transcriptome in calves infected with bovine respiratory syncytial virus and treated with antiviral and/or cyclooxygenase inhibitor, PLoS One, 16 e0246695, 2021.
43. Baker J.C., Ellis J.A., Clark E.G. Bovine respiratory syncytial virus, Veterinary Clinics of North America: Food Animal Practice, 13 425-454, 1997.
44. Masot A.J., Kelling C.L., Lopez O., Sur J.H., Redondo E. In situ hybridization detection of bovine respiratory syncytial virus in the lung of experimentally infected lambs, Veterinary Pathology, 37 618-625, 2000.
45. Ohlson A., Emanuelson U., Traven M., Alenius S. The relationship between antibody status to bovine corona virus and bovine respiratory syncytial virus and disease incidence, reproduction and herd characteristics in dairy herds, Acta Veterinaria Scandinavica, 52:1 1-7, 2010.
46. Saa L.R., Perea A., Jara D.V., Arenas A.J., GarciaBocanegra I., Borge C., Carbonero A. Prevalence of and risk factors for bovine respiratory syncytial virus (BRSV) infection in non-vaccinated dairy and dual-purpose cattle herds in Ecuador, Tropical Animal Health and Production, 44 1423-1427, 2012.
47. Beker M., Rose S., Lykkebo C.A., Douthwaite S. Integrative and conjugative elements (ICEs) in Pasteurellaceae species and their detection by multiplex PCR, Frontiers In Microbiology, 9 1329, 2018.
48. Welsh R.D., Dye L.B., Payton M.E., Confer A.W. Isolation and antimicrobial susceptibilities of bacterial pathogens from bovine pneumonia: 1994-2002, Journal of Veterinary Diagnostic Investigation, 16 426-431, 2004.
49. Wilson B. A., Ho M. Pasteurella multocida: From zoonosis to cellular microbiology, Clinical Microbiology Reviews, 26 631-655, 2013.
50. Angen Ø., Ahrens P., Kuhnert P., Christensen H., Mutters R. Proposal of Histophilus somni gen. Nov., sp. Nov. For the three species incertae sedis 'Haemophilus somnus', 'Haemophilus agni' and 'Histophilus ovis'. International Journal of Systematic and Evolutionary Microbiology, 53 1449-1456, 2003.
51. Gagea M.I., Bateman K.G., van Dreumel T., McEwen B.J., Carman S., Archambault M., Shanahan R.A., Caswell J.L. Diseases and pathogens associated with mortality in ontario beef feedlots, Journal of Veterinary Diagnostic Investigation, 18 18-28, 2006.
52. Ward A.C.S., Weiser G.C., Anderson B.C., Cummings P.J., Arnold K.F., Corbeil L.B. Haemophilus somnus (Histophilus somni) in bighorn sheep, Canadian Journal of Veterinary Research, 70 34-42, 2006.
53. Dyer N.W. Haemophilus somnus bronchopneumonia in American bison (Bison bison), Journal of Veterinary Diagnostic Investigation, 13 419-421, 2001.
54. Confer A.W. Update on bacterial pathogenesis in BRD, Animal Health Research Reviews, 10 145-148, 2009.
55. Corbeil L.B. Histophilus somni host-parasite relationships, Animal Health Research Reviews, 8 151160, 2007.
56. Nicholas R.A., Ayling R.D. Mycoplasma bovis: Disease, diagnosis, and control. Research in Veterinary Science, 74 105-112, 2003.
57. Maunsell F.P., Chase C. Mycoplasma bovis: Interactions with the immune system and failure to generate an effective immune response, Veterinary Clinics: Food Animal Practice, 35 471-483, 2019.
58. Lysnyansky I., Freed M., Rosales R.S., Mikula I., Khateb N., Gerchman I., van Straten M., Levisohn S. An overview of mycoplasma bovis mastitis in Israel (20042014), The Veterinary Journal, 207 180-183, 2016.
59. Maunsell F.P., Donovan G.A. Mycoplasma bovis infections in young calves, Veterinary Clinics of North America: Food Animal Practice, 25 139-177, 2009.
60. Kanda T., Tanaka S., Suwanruengsri M., Sukmawinata E., Uemura R., Yamaguchi R., Sueyoshi M. Bovine endocarditis associated with mycoplasma bovis, Journal of Comparative Pathology, 171 53-58, 2019.
61. Alberti A., Addis M.F., Chessa B., Cubeddu T., Profiti M., Rosati S., Ruiu A., Pittau M. Molecular and antigenic characterization of a Mycoplasma bovis strain causing an outbreak of infectious keratoconjunctivitis, Journal of Veterinary Diagnostic Investigation, 18 41-51, 2006.
62. Gondaira S., Nishi K., Tanaka T., Yamamoto T., Nebu T., Watanabe R., Konnai S., Hayashi T., Kiku Y., Okamoto M., Matsuda K., Koiwa M., Iwano H., Nagahata H., Higuchi H. Immunosuppression in cows following intramammary infusion of Mycoplasma bovis, Infection and Immunity, 88 e00521-19, 2020.
63. Sajiki Y., Konnai S., Goto S., Okagawa T., Ohira K., Shimakura H., Maekawa N., Gondaira S., Higuchi H., Tajima M., Hirano Y., Kohara J., Murata S., Ohashi K. The suppression of Th1 response by inducing TGF-beta1 from regulatory T cells in bovine mycoplasmosis, Frontiers In Veterinary Science, 7 609443, 2020.
64. Studer E., Schonecker L., Meylan M., Stucki D., Dijkman R., Holwerda M., Glaus A., Becker J. Prevalence of BRD-related viral pathogens in the upper respiratory tract of swiss veal calves, Animals, 11 1940, 2021.
65. Paller T., Hostnik P., Pogacnik M., Toplak I. The prevalence of ten pathogens detected by a real-time PCR method in nasal swab samples collected from live cattle with respiratory disease. Slovenian Veterinary Research, 54 101-107, 2017.
66. Vallejo J. Prevalence of bovine viral diarrhea virus subspecies among persistently infected positive samples submitted to a diagnostic laboratory from cattle in the United States, The Degree of Doctor of Pathobiology, Kansas State University, 2020.
67. Aslan M.E., Azkur A.K., Gazyagci S. Epidemiology and genetic characterization of BVDV, BHV-1, BHV-4, BHV-5 and Brucella spp. infections in cattle in Turkey, Journal of Veterinary Medical Science, 77 1371-1377, 2015.
68. Gur S. Prevalence of bovine viral diarrhoea, bovine herpesvirus type 1 and 4 infections in repeat breeding cows in western Turkey, Brazilian Journal of Veterinary Research and Animal Science, 48 228-233, 2011.
69. McMullen C., Alexander T.W., Leguillette R., Workentine M., Timsit E. Topography of the respiratory tract bacterial microbiota in cattle, Microbiome, 8 91, 2020.
70. Bell R.L., Turkington H.L., Cosby S.L. The bacterial and viral agents of BRDC: Immune evasion and vaccine developments, Vaccines, 9 337, 2021.
71. Joshi V., Gupta V.K., Kumar O.R.V., Pruthvishree B.S., Dimri U., Alam S. Bovine respiratory disease- an updated review, Journal of Immunology and Immunopathology, 18 86-93, 2016.
72. Perino L.J., Apley M.D. Clinical trial design in feedlots, Veterinary Clinics of North America: Food Animal Practice, 14 343-365, 1998.
73. Richeson J.T., Pinedo P.J., Kegley E.B., Powell J.G., Gadberry M.S., Beck P.A., Falkenberg S.M. Association of hematologic variables and castration status at the time of arrival at a research facility with the risk of bovine respiratory disease in beef calves, Journal of the American Veterinary Medical Association, 243 10351041, 2013.
74. Martin S.W., Lumsden J.H. The relationship of hematology and serum chemistry parameters to treatment for respiratory disease and weight gain in ontario feedlot calves, Canadian Journal of Veterinary Research, 51 499505, 1987.
75. Autio T., Pohjanvirta T., Holopainen R., Rikula U., Pentikainen J., Huovilainen A., Rusanen H., Soveri T., Sihvonen L., Pelkonen S. Etiology of respiratory disease in non-vaccinated, non-medicated calves in rearing herds, Veterinary Microbiology, 119 256-265, 2007.
76. Jamali H., Rezagholipour M., Fallah S., Dadrasnia A., Chelliah S., Velappan R.D., Wei K.S., Ismail S. Prevalence, characterization and antibiotic resistance of Pasteurella multocida isolated from bovine respiratory infection, The Veterinary Journal, 202 381-383, 2014.
77. Ollivett T.L., Buczinski S. On-farm use of ultrasonography forbovine respiratory disease, The Veterinary Clinics of North America. Food Animal Practice, 32 19-35, 2016.
78. Braun U. Traumatic pericarditis in cattle: Clinical, radiographic and ultrasonographic findings, The Veterinary Journal, 182 176-186, 2009.
79. Flock M. Diagnostic ultrasonography in cattle with thoracic disease, The Veterinary Journal, 167 272-280, 2004.
80. Andrews A.H. Calf Respiratory Diseases. In: Andrews AH, Blowey RW, Boyd H, Eddy RG editors. Bovine Medicine: Diseases and Husbandry of Cattle, Edition 2, Oxford, Blackwell Science, s. 239-248, 2008.
81. Theurer M.E., Larson R.L., White B.J. Systematic review and meta-analysis of the effectiveness of commercially available vaccines against bovine herpesvirus, bovine viral diarrhea virus, bovine respiratory syncytial virus, and parainfluenza type 3 virus for mitigation of bovine respiratory disease complex in cattle, Journal of the American Veterinary Medical Association, 246 126-142, 2015.
82. Stilwell G., Matos M., Carolino N., Lima M.S. Effect of a quadrivalent vaccine against respiratory virus on the incidence of respiratory disease in weaned beef calves, Preventive Veterinary Medicine, 85 151-157, 2008.
83. Wildman B.K., Perrett T., Abutarbush S.M., Guichon P.T., Pittman T.J., Booker C.W., Schunicht O.C., Fenton R.K., Jim G.K. A comparison of 2 vaccination programs in feedlot calves at ultra-high risk of developing undifferentiated fever/bovine respiratory disease, The Canadian Veterinary Journal, 49 463-472, 2008.
84. Chamorro M.F., Palomares R.A. Bovine respiratory disease vaccination against viral pathogens: Modifiedlive versus inactivated antigen vaccines, intranasal versus parenteral, what is the evidence? Veterinary Clinics of North America: Food Animal Practice, 36 461-472, 2020.
85. Gorden P.J., Plummer P. Control, management, and prevention of bovine respiratory disease in dairy calves and cows, Veterinary Clinics: Food Animal Practice, 26 243-259, 2010.
86. Hilton W.M. BRD in 2014: Where have we been, where are we now, and where do we want to go? Animal Health Research Reviews, 15 120-122, 2014.