Vücut Geliştiricide İntramuskuler Synthol Enjeksiyonuna Bağlı Lipoid Pnömoni

Year 2019, Volume: 6 Issue: 1, 48 - 51, 20.03.2019

Nesrin Öcal Armağan Günal Yakup Arslan Berat Kaçmaz Ali Coşkun Bahadır Can Karan Deniz Doğan Cantürk Taşçı Ergün Uçar

Abstract

Bu makalede kas dolgusu amacıyla sentetik bir
yağ türevi olan “Synthol” un tekrarlayan intramuskuler kullanımı nedeniyle
gelişen kronik eksojen lipoid pnömoni olgusu sunulmuştur. Göğüs kaslarını
büyütmek için Synthol kullanan 40 yaşında erkek hasta, bir yıl içinde ilerleyen
nefes darlığı ile birlikte polikliniğimize başvurdu. Toraks tomografisinde
interstisyel akciğer hastalığı ile uyumlu retikülasyonlar ve septal
kalınlaşmalar izlenmekteydi. Hastaya bronkoskopi yapıldı. Bronkoalveolar lavaj ve
transbronşiyal biyopsi (TBB) alındı. TBB'nin histopatolojik incelemesinde,
intraalveoler ve interstisyel yağlı makrofajlar, yağ partikülleri etrafındaki
dev hücreler ve ekstraselüler yağ partikülleri gözlendi. Örnek “lipoid pnömoni”
olarak raporlandı. Bizim bilgimize göre Synthol'un intramusküler kullanımına
bağlı ekzojen lipoid pnömonisi şimdiye kadar bildirilmemiştir ve olgumuz
literatürdeki ilk olgudur.

Keywords

Synthol, Lipoid Pnömoni, Sentetik Yağ, Vücut Geliştirme

Exogenous Lipoid Pneumonia Due To Intramuscular Injection of Synthol in a Bodybuilder

Abstract

We report a case of chronic exogenous lipoid
pneumonia that developed due to recurrent intramuscular use of “Synthol”, a
synthetic oil derivative, for muscle filling. 40-year-old man, who had used
Synthol to enlarge his pectoral muscles, was admitted to the chest diseases
polyclinic with shortness of breath progressing within a year. On computerized
tomography of thorax there were reticulations and septal thickenings consistent
with interstitial lung disease. The patient underwent bronchoscopy.
Bronchoalveolar lavage and transbronchial biopsy (TBB) were performed. In the
histopathologic study of TBB, intraalveolar and interstitial fatty macrophages,
giant cells around fat particles and extracellular fat particles were observed
and the specimen was reported as "lipoid pneumonia". According to our
knowledge, exogenous lipoid pneumonia due to intramuscular use of Synthol has
not been reported heretofore and this is the first case in the literature.

Keywords

Bodybuilder, Lipoid Pneumonia, Synthetic Oil, Synthol

References

• 1. Gondouin A, Manzoni PH, Ranfaing E, et al. Exogenous lipid pneumonia: a retrospective multicentric study of 44 cases in France. Eur Respir J. 1996;9:1463–9.
• 2. Cherrez Ojeda I, Calderon JC, Guevara J, Cabrera D, Calero E, Cherrez A. Exogenous lipid pneumonia related to long-term use of Vicks VapoRub by an adult patient: a case report. BMC Ear, Nose Throat Disord. 2016;16:11.
• 3. Betancourt SL, Martinez-Jimenez S, Rossi SE, Truong MT, Carrillo J, Erasmus JJ.Lipoid pneumonia:spectrum of clinical and radiologic manifestations. Am J Roentgenol. 2010;194:103-9.
• 4. Laughlin GF. Studies of pneumonia following injections of oil. Am J Pathol. 1925;1:407–14.
• 5. Marchiori E, Zanetti G, Mano CM, Irion KL, Daltro PA, Hochhegger B. Lipoid pneumonia in 53 patients after aspiration of mineral oil: comparison of high-resolution computed tomography findings in adults and children. J Comput Assist Tomogr. 2010; 34(1): 9-12.
• 6. Rahaghi F, Varasteh A, Memarpour R, Tashtoush B. Teppanyaki/Hibachi Pneumonitis: An Exotic Cause of Exogenous Lipoid Pneumonia. Case Rep Pulmonol. 2016; 2016: 1035601.
• 7. Hotta T, Tsubata Y, Okimoto T, Hoshino T, Hamaguchi S, Isobe T. Exogenous lipoid pneumonia caused by herbicide inhalation. Respirol Case Rep. 2016;4(5): e00172.
• 8. Yasui H, Yokomura K, Suda T. A severe case of acute exogenous lipoid pneumonia treated with systemic corticosteroid. Respir Med Case Rep. 2016;17: 64–7.
• 9. Russell M, Storck A, Ainslie M. Acute respiratory distress following intravenous injection of an oil-steroid solution. Can Respir J. 2011;18(4): 59–61.
• 10. Fumo G, Ferreli C, Murgia S, Galletti R, Pau M. A serious complication due to liquid silicone injection in the legs for cosmetic purpose. Clin Ter. 2013;164(5):377-9.
• 11. Gersuny R. Ueber eine subcutyane Prothese. Z Heilk. 1900;30:1–5.
• 12. Pupka A, Sikora J, Mauricz J, Cios D, Plonek T. The usage of synthol in the body building. Polim Med. 2009;39:63–5.
• 13. Ghandourah S, Hofer MJ, Kießling A, El-Zayat B, Schofer MD. Painful muscle fibrosis following synthol injections in a bodybuilder: a case report. J Med Case Rep. 2012;6:248.
• 14. https://www.pneumotox.com/drug/view/1171/synthol