Predictive Role of Neutrophil to Lymphocyte Ratio in Differentiation of Different Thyroid Pathologies

Year 2019, Volume: 6 Issue: 1, 16 - 20, 20.03.2019

İbrahim Atak , Lütfi Polat Tuba Atak

Abstract

The
neutrophil/lymphocyte ratio (NLR) and platelete/ lymphocyte ratio (PLR) is a
simple marker of systemic inflamatory response. The aim of this study was to
examine the relationship of NLR and PLR with thyroid cancer and different
benign thyroidal pathologies such as multi nodular goiter and thyroiditis. 331
patients who underwent thyroidectomy in general surgery department of our
hospital between 2015 and 2017 were evaluated. Laboratory findings, demographic
characteristics and pathology reports of patients were retrospectively
reviewed. Patients were devided into four groups according to pathological
reports. 241 of 331 patients were diagnosed with MNG (MNG Group), 17 were
thyroiditis (T group), 49 were thyroid carcinomas (TK Group) and 24 were
thyroid carcinoma with thyroiditis (T-TK Group). Patients were also devided into
two groups according to precence of malignancy as benign (n=258) and malign
(n=73). NLR and PLR values of groups were compared. 292 (88.2%) of paitents
were female and 39 (11.8%) were male with a mean age was 50.52±12.08 years.
There was no statistically significant difference between four groups in terms
of NLR and PLR values (p>0.05). However, according to presence of
malignancy,  NLR values of malignant
group was found to be statistically higher than the NLR values of benign group
(p=0.039; p<0.05). There were no difference between two groups according to
PLR values (p>0.05). In our study, there was no relationship between
different thyroid pathologies and NLR and PLR. There is a need for prospective,
randomized, large series of studies on the subject.

Keywords

Goiter, Neutrophil/Lymphocyte Ratio, Thyroid Carcinomas

Farklı Tiroid Patolojilerinin Ayrımında Nötrofil Lenfosit Oranının Prediktif Rolü

Abstract

Nörtofil lenfosit
oranı (NLO) ve platelet lenfosit oranı (PLO) sistemik enflamatuar yanıtın basit
bir göstergesidir ve bazı hastalıklarda prognostik olduğu gösterilmiştir. Bu
çalışma NLO ve PLO ile tiroid kanseri ve tiroidin multinodüler guatr ve
tiroidit gibi diğer benign hastalıkları arasındaki ilişkiyi ortaya koymak amacı
ile gerçekleştirildi. Hastanemiz genel cerrahi kliniğinde 2015-2017 yılları
arasında tiroidektomi ameliyatı olan 331 hasta değerlendirildi. Hastaların
laboratuar bulguları, demografik özellikleri ve patoloji raporları geriye dönük
olarak incelendi. Patoloji raporlarına göre hastalar 4 gruba ayrıldı. 331
hastanın 241’ine MNG (MNG Grup), 17’sine tiroidit (T Grup), 49’una tiroid
karsinomu (TK Grup), 24’üne ise tiroidit ile birlikte tiroid karsinomu (T-TK
Grup) teşhisi konuldu. Hastalar ayrıca malignite varlığına göre göre benign
(n=258) ve malign (n=73) olarak 2 gruba ayrıldı. Grupların NLO ve PLO değerleri
karşılaştırıldı. Hastaların 292’si kadın (%88.2), 39’u erkek (%11.8) olup
ortalama yaş 50.52±12.08 idi. Dört grup arasında NLO ve PLO değeri açısından
istatistiksel olarak anlamlı fark saptanmadı (p>0.05). Bununla birlikte
malignite varlığına göre malign grubun NLO değeri, benign grubun NLO değerine
göre istatistiksel olarak anlamlı düzeyde yüksek saptandı (p=0.039; p<0.05).
Malignite varlığına göre grupların PLO ölçümleri arasında istatistiksel olarak
anlamlı farklılık saptanmadı (p>0.05). Bizim çalışmamızda farklı tiroid
patolojileri ile NLO ve PLO arasında ilişki saptanmadı. Konu ile ilgili
prospektif, randomize geniş serili çalışmalara ihtiyaç duyulmaktadır.

Keywords

Guatr, Tiroid Karsinomu, Nötrofil/Lenfosit Oranı

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