Temporal Bölge Üzerindeki Cilde Metastaz Yapan Renal Hücreli Karsinom: Nadir Bir Klinik Sunum

Year 2020, Volume: 7 Issue: 2, 106 - 107, 31.08.2020

Şükrü Kasap , Havva Solak Özşeker Özgür Tanrıverdi , Mustafa Nişancı

Abstract

Renal Hücreli Kanser (RHK) tanı esnasında ve primer tedaviden seneler sonra metastaz yapmasıyla oldukça bilinmektedir. Akciğer, karaciğer ve dalak en çok metastaz olan organlar olarak sunulsa da RHK nadiren skalp üzerine metastaz yapar. Benzer şekilde, ülsere ve enfekte skalp lezyonları da lezyonsuz sınırlarla eksize edilmeli ve RHK şüphesiyle immünohistokimya ile değerlendirilmelidir. Biz burada nadir görülen nefrektomiden 10 sene sonra sol temporal bölgede yoğun kanamaya bağlı derin anemiye yol açan bir metastatik RHK ülseronodüler lezyonlu vakayı sunduk ve güncel literatür eşliğinde RHK’un cilt metastazının doğasını tartıştık.

Keywords

Renal hücreli karsinom, skalp, metastaz

Renal Cell Carcinoma Metastizing to Skin Over Temporal Region: A Rare Clinical Presentation

Abstract

Renal cell carcinoma (RCC) is known to undergo metastasis during diagnosis and after a period of primary therapy. Although the lung, liver and spleen are presented as the most metastatic organs, RCC rarely metastasizes to thescalp. Likewise, ulceration and infected scalp lesions should be excised with no lesions and RCC should be evaluated with immunohistochemistry with the suspicion of RCC. Here we presented a rare case of metastatic RCC ulceronodular lesion that led to a deep anemia of dense hemorrhage in the left temporal region 10 years after nephrectomy and discussed the nature of RCC skin metastasis in the light of current literature.

Keywords

Renal cell carcinoma, scalp, metastasis

References

• Ritchie AW, Chisholm GD. The natural history of renal carcinoma. Semin Oncol. 1983;10(4):390-400.
• Azam F, Abubakerr M, Gollins S. Tongue metastasis as an initial presentation of renal cell carcinoma: a case report and literature review. J Med Case Rep. 2008;2:249.
• Ferlay J, Bray F, Pisani P, Parkin D. Cancer Incidence, Mortality and Prevalence. Worldwide. IARC Cancer Base No. 5, IARC Press, Lyon, 2004 version 2.0.
• Motzer RJ, Bacik J, Mazumdar M. Prognostic factors for survival of patients with stage IV renal cell carcinoma: memorial sloan-kettering cancer center experience. Clin Canc Res. 2004;10(18):6302–3.
• Errami M, Margulis V, Huerta S. Renal Cell Carcinoma Metastatic to the Scalp. Rare Tumors. 2016;20;8(4):6400.
• Livingston WD, Becker DW, Lentz CW. Solitary scalp metastasis as the presenting feature of a renal carcinoma. Br J Plast Surg. 1977;30(4):319-20.
• Snow S, Madjar D, Reizner G, MacK E, Bentz M. Renal cell carcinoma metastatic to the scalp: case report and review of the literature. Dermatol Surg. 2001;27(2):192-4.
• Eke N, Eghwrudjakpor P, Echem RC. Renal cell carcinoma presenting as a scalp swelling. Niger J Med. 2003;12(3):154-6.
• Pan D, Niall O, Sharma H, Gya D. Isolated scalp nodule in patient with undiagnosed RCC. Sci World J. 2006;6:2430-2.
• Barry Delongchamps N, Peyromaure M, Debre B, Zerbib M. [Renal cancer presenting as an isolated cutaneous metastasis]. Prog Urol. 2004;14(4):538-9.
• Barbagelata López A, RuibalMoldes M, Blanco Díez A, et al. [Cutaneous metastasis of a renal carcinoma: case report and review]. ArchEspUrol. 2005;58(3):247-50.
• Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 2007;356(2):115-24.
• Rini BI. Vascular endothelial growth factor- targeted therapy in renal cell carcinoma: current status and future directions. ClinCancerRes 2007;13(4):1098-106.
• Motzer RJ, Escudier B, Oudard S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet. 2008;372(9637):449-56.
• Gay HA, Cavalieri R, Allison RR, Finley J, Quan WD. Complete response in a cutaneous facial metastatic nodule from renal cell carcinoma after hypofractionated radiotherapy. Dermatol Online J. 2007;13(4):6.