Compliance with Lipid-Lowering Therapy Use and Achieving LDL-Cholesterol Target Levels in Patients with Coronary Artery Disease in The Cardiology Clinic of Kayseri City Hospital

Year 2020, , 84 - 90, 31.01.2020

Ömer Şahin

https://doi.org/10.31020/mutftd.650069

Cited By: 1

Abstract

Introduction: Atherosclerotic heart disease is the
leading cause of morbidity and mortality worldwide.When we look at the
pathogenesis of atherosclerosis, dyslipidemias are one of the most common and
correctable risk factor. In this study, we aimed to investigate lipid-lowering
drug therapies and lipid levels in patients who needed lipid-lowering therapy
due to coronary artery disease in cardiology clinic.

Method: Patients who were previously documented with
coronary artery disease by coronary angiography between December 2018 and July
2019 were examined for lipid-lowering therapy.

Result: Total cholesterol and LDL-cholesterol levels
were significantly lower in the lipid lowering group (198.1±40.4 ve 171.6±35.1,
p≤0.001, 118,69±36.4 ve 92.2±31.5, p≤0.001, respectively). When we analyzed
patients reaching LDL-cholesterol<55 mg / dL target value, one patient in
the non-lipid lowering group achieved the target, while 20 patients in the
lipid lowering group achieved the target (p=0.023).

Conclusion: In our study, it was found that the
patients who were in a very high risk group due to coronary artery disease and
who needed lipid-lowering treatment for secondary prevention did not use
effective doses of medication.[o1] 
The number of patients achieving LDL-cholesterol target was low in patients
receiving lipid lowering therapy regardless of the dose used.

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Keywords

Coronary artery disease, Lipid-lowering treatment

Kayseri Şehir Hastanesi Kardiyoloji Kliniğinde Koroner Arter Hastalığı Olan Hastalarda Lipid Düşürücü İlaç Kullanımına Uyum ve LDL-Kolesterol Hedefine Ulaşma Düzeyleri

Abstract

Giriş: Aterosklerotik kalp hastalıkları tüm dünyada önde
gelen morbidite ve mortalite nedenidir. Aterosklerozun patogenezine
bakıldığında, dislipidemiler en yaygın ve düzeltilebilen risk faktörlerinden
biridir. Bu çalışmamızda kardiyoloji kliniğinde takip etmekte olduğumuz koroner
arter hastalığı nedeniyle lipid düşürücü tedavi alması gereken hastaların lipid
düşürücü ilaç tedavileri ve lipid düzeylerinin incelenmesi amaçlanmıştır.

Yöntem: Aralık 2018 ile Temmuz 2019 arasında kardiyoloji
kliniğine başvuran daha önce koroner anjiografi ile koroner arter hastalığı
dökümante edilmiş hastalar lipid düşürücü ilaç tedavileri yönünden incelendi.

Bulgular: Lipid düşürücü ilaç kullanan grupta total
kolesterol ve LDL-kolesterol seviyelerinin anlamlı olarak düşük olduğu tespit
edildi (sırasıyla 198.1±40.4 ve 171.6±35.1, p≤0.001, 118,69±36.4 ve 92.2±31.5,
p≤0.001). LDL-kolesterol<55 mg/dL hedef değerine ulaşan hastaları
incelediğimizde, lipid düşürücü ilaç kullanmayan grupta bir hastada hedefe
ulaşılırken, lipid düşürücü tedavi alan grupta 20 hastanın hedefe ulaştığı
gözlendi (p=0.023).

Sonuç: Çalışmamızda koroner arter hastalığı nedeniyle
çok yüksek risk grubunda olan ve ikincil koruma amaçlı lipid düşürücü tedavi
alması gereken hastaların etkin dozda ilaç kullanmadıkları tespit edildi. Lipid
düşürücü tedavi alan hastalarda kullanılan dozdan bağımsız olarak
LDL-kolesterol hedefine ulaşan hasta sayısı düşük bulunmuştur.

Keywords

Koroner arter hastalığı, Lipid düşürücü tedavi

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