Bir Probiyotik Olarak Kefir’İn Günlük Besin Desteğinden Yoğun Bakımda Kullanımına Uzanan Öyküsü

Year 2020, , 295 - 301, 23.09.2020

Harun Ozmen , Bahar Aydınlı

https://doi.org/10.31020/mutftd.730594

Abstract

Kefirin insan sağlığı üzerine pek çok olumlu etkisi olduğu gösterilmiştir. Bu etkiler, fermentasyonu sırasında oluşan yeni bileşenler ve sahip olduğu mikrobiyatası ile oluşur. Probiyotiklerin insan sağlığı üzerindeki olumlu etkilerinin bilimsel gerçekliği ilk kez Elie Metchnikoff tarafından yoğurt üzerinde yaptığı çalışmanın sonucu teorize edilmiştir. Kefir mikrobiyatası gastrointestinal sistem üzerine pek çok hücresel ve humoral olumlu etki yapar. Bunun sonucunda arteriosiklerozis, metabolik, alerjik hastalıklarda önemli iyileştirici etkileri görülür. Bununla beraber antimikrobiyal, antikarsinojenik ve bağışıklık sisteminin güçlendirilmesi gibi etkileri de sağlık alanında yaygın kullanımına yol açmıştır. Kritik hastalıklarda beslenme rejimine ek olarak verilen probiyotikler yenidoğan ve yaşlı hastalara kadar geniş hasta grubunda iyileşmeye ciddi katkılar sağlamıştır. Son çalışmalarda kanser hastaları, inflamatuvar hastalığı olanlarda, enfeksiyon hastaları ve travma hastalarında olmak üzere yapılan çalışmalar özellikle hastalık seyrinin iyileştirilmesi, sürecin kısalması ve hayatta kalma üzerine kanıta dayalı olumlu sonuçlar alınmıştır. Bu derlemede kefirin kaynağı, fermentasyon süreci, mikrobiyal ve biyokimyasal özellikleri ve günlük beslenmeden yoğun bakıma kadar giden süreçte beslenmeye eklenmesiyle elde edilmiş sonuçların bilimsel dayanakları ile gözden geçirilmesi amaçlandı.

Keywords

kefir, sağlık, yoğun bakım

Supporting Institution

YOKTUR

Project Number

YOKTUR

A Probiotic History From Kefir's Daily Food Support to Intensive Care

Abstract

Kefir has been shown to have many positive effects on human health. These effects occur with the new components that are formed during fermentation and the microbiota it has. The scientific reality of the positive effects of probiotics on human health was theorized for the first time by Elie Metchnikoff in his work on yogurt. Kefir microbiota has many cellular and humoral positive effects on the gastrointestinal tract. As a result, significant healing effects are seen in arteriosclerosis, metabolic and allergic diseases. However, its effects such as antimicrobial, anticarcinogenic and strengthening of the immune system have also led to its widespread use in the field of health. Probiotics, which are given in addition to the nutritional regimen in critical diseases, have made significant contributions to recovery in a wide range of patients, from neonates to elderly patients. Evidence-based positive results have been obtained in recent studies, especially in patients with cancer, inflammatory disease and infection patients , trauma patients, especially on the improvement of the course of the disease, shortening of the process and survival. In this review, it was aimed to review the results obtained with the source of kefir, the fermentation process, its microbial and biochemical properties and the addition of it to the diet from daily nutrition to intensive care.

Keywords

Kefir, health, intensive care

Project Number

YOKTUR

References

• 1-Koyu EB, Demirel ZB. Fonksiyonel Bir Besin: Kefir. Bes Diy Derg 2018;46(2):166-175.
• 2- Ahmed Z., et al. Kefir and health: A contemporary perspective. Crit Rev Food Sci Nutr 2013;53(5):422-434.
• 3- Rosa DD., et al. Milk kefir: Nutritional, microbiological and health benefits. Nutr Res Rev 2017;30(1):82-96.
• 4- Otles S, Cagindi O. Kefir: A probiotic dairy-composition, nutritional and therapeutic aspects. Pakistan J Nutr 2003;2(2):54-59. 5- de Oliveira Leite AM, et al. Microbiological, technological and therapeutic properties of kefir: A natural probiotic beverage. Braz J Microbiol 2013;44(2):341-349.
• 6- Türk Dil Kurumu Güncel Sözlük. Erişim adresi: http://tdk.gov.tr/
• 7- Karatepe P, Yalçın H. Kefirli Sağlık. Iğdır Üni. Fen Bilimleri Enst. Der 2014;4(2):23-30.
• 8-Koçak C, Gürsel A. Kefir. Gıda 1981;6(4):11-14
• 9- Garrote GL, Abraham AG, De Antoni GL. Microbial interactions in kefir: A natural probiotic drink. In: Mozzi F, Raya RR, Vignolo GM, editors. Biotechnology of Lactic Acid Bacteria. 1st ed. Blackwell Publishing; 2010. p. 327-340.
• 10- Guzel-Seydim Z, Kök-Taş T, Greene AK. Kefir and koumiss: Microbiology and technology. In: Yıldız F. Development and Manufacture of Yogurt and Other Functional Dairy Products. 1st ed. CRC Press; 2010. p. 143-163.
• 11- Duitschaever, CL, Kemp, N, Emmons, D. Pure culture formulation and procedure for the production of kefir. Milchwissenschaft, 1987,4: 80-82.
• 12- Tomar O, Çağlar A, Akarca G. Kefir ve Sağlık Açısından Önemi. AKÜ FEMÜBİD 17 2017; 027202: 834-853.
• 13- Turan İ, ve ark. Effects of a kefir supplement on symptoms, colonic transit, and bowel satisfaction score in patients with chronic constipation: a pilot study. Turk J Gastroenterol. 2014;25(6):650-6.
• 14- Probiyotik Nedir? Erişim adresi: https://www.enterogermina.com.tr/probiyotik-nedir-nasil-kullanilir
• 15- Gönülateş N. Kefirin İnsanlar Üzerindeki İmmünomodülatör Etkilerinin Araştırılması. Bitirme Tezi. S. D. Ü Tıp Fakültesi Mikrobiyoloji Ana Bilim Dalı. Isparta, 2008.
• 16- Kopp-Hoolihan L. Prophylactic and therapeutic uses of probiotics: a review. J Am Diet Assoc 2001;101:229–238.
• 17- Ötleş S, Çağındı Ö, Akçiçek E. Probiotics and health. Asian Pacific J Cancer Prev 2003; 4: 369–372.
• 18- Sanders M.E. Probiotics: considerations for human health. Nutr Rev 2003; 61: 91–99.
• 19- Mackowiak. P.A. Recycling Metchnikoff: Probiotics, the Intestinal Microbiome and the Quest for Long Life. Front Public Health. 2013. Accessed: https://www.frontiersin.org/articles/10.3389/fpubh.2013.00052/full
• 20- Zacconi, C, et al. Competitive exclusion of Salmonella Kedougou in kefir fed chicks. Microbiologie, Aliments, Nutrition 1995;12:387-390
• 21- Furukawa N, Matsuoka A, Yamanaka Y. Effects of orally administered yogurt and kefir on tumor growth in mice. Journal of Japanese Society of Nutrition and Food Science 1990;43(6):450-453.
• 22- Furukawa N, et al. Effects of fermented milk on the delayed type hypersensitivity response and survival day in mice bearing meth-A. Animal Science and Technology 1991;62: 579-585.
• 23- Tamai Y, et al. Effect of milk fermented by culturing with various lactic acid bacteria and a yeast on serum cholesterol level in rats. Journal of Fermentation Bioengineering 1996;81:181-182.
• 24- Çevikbaş A, ve ark. Antitumoural, antibacterial and antifungal activities of kefir and kefir grain. Phytotherapy Research 1994;8:78-82.
• 25- Koroleva N. S. Technology of kefir and kumys. International Dairy Federation Bulletin 1988;22:96-100.
• 26- Simon O. Micro-organisms as feed additives—Probiotics. Adv. Pork Prod 2005;16:161–167
• 27- Markowiak P, K Śliżewska K. Effects of Probiotics, Prebiotics, and Synbiotics on Human Health.Nutrients 2017;9(9):1021 28- Bourrie BCT, Willing BP, Cotter PD. The microbiota and health promoting characteristics of the fermented beverage kefir. Front Microbiol 2016;7:647.
• 29- T.C. Gıda, Tarım ve Hayvancılık Bakanlığı, Türk Gıda Kodeksi Fermente Süt Ürünleri Tebliği, Tebliğ No (2009/25). Resmi Gazete: 16.02.2009-27143. Erişim adresi: http:// www.resmigazete.gov.tr/eskiler/2009/02/20090216-8.
• 30- Gürsoy O, Kınık Ö, Gönen İ. Probiyotikler ve Gastrointestinal Sağlığa Etkileri. Türk Mikrobiyol Cem Derg 2005;35:136-148. 31- Kefirin Tarihi Erişim adresi: http://kefirci.com/soru-cevap/kefirin-tarihcesi
• 32- Kefirin mikrobiyolojik tarihi. Erişim adresi: http://www.invenura.com/kefirin-mikrobiyolojik-tarihi
• 33- Kural B. Çocuklarda Kanıta Dayalı Probiyotik Kullanımı. Osmangazi Tıp Dergisi Sosyal Pediatri Özel Sayısı 2020;Mart:41- 45
• 34- Dan W. Thomas, Frank R. Greer and Committee on Nutrition; Section on Gastroenterology, Hepatology, and Nutrition. Probiotics and Prebiotics in Pediatrics. Pediatrics 2010 ;126:1217-31.
• 35- Ong T, et al. Probiotics to prevent infantile colic. Cochrane Database of Systematic Reviews 2019, Issue 3. Art. No: CD012473.
• 36- Sung V, et al. Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomised trial. BMJ 2014;348 :g2107
• 37. AlFaleh K, Anabrees J. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database of Systematic Reviews 2014, Issue 4. Art. No: CD005496. 12
• 38-www.ciftlikdergisi.com.tr.(Anonim)
• 39-Otles S, Cagindi O. Kefir: A Probiotic Dairy-Composition, Nutritional and Therapeutic Aspects. Pakistan Journal of Nutrition 2003;2(2):54-59.
• 40- Ibrahim Almostafa Alsha'ar I.A et all. In Vitro Anticancer Propertiesof Kefirand Kefir Products Produced by a Novel Method in Syria. International Journal of .Pharmaceutical Science Invention ISSN (Online): 2319 – 6718
• 41- Turan İ,ve ark. Effects of a kefir supplement on symptoms, colonic transit, and bowel satisfaction score in patients with chronic constipation: A pilot study.Turk J Gastroenterol 2014;25:650-6
• 42- Allen SJ, et al. Probiotics for treating acute infectious diarrhoea. Cochrane Database of Systematic Reviews 2010, Issue 11. Art. No.: CD003048.
• 43- Marchand V. Using probiotics in the paediatric population. Paediatr Child Health 2012;17:575-6.
• 44- Bernaola Aponte G, et al. Probiotics for treating persistent diarrhoea in children. Cochrane Database of Systematic Reviews 2010, Issue 11. Art. No.: CD007401. 45- Isolauri E. Probiotics for infectious diarrhoea. Gut 2003;52:436.
• 46- Özden A. 1908 Nobel Tıp Ödülü . Güncel Gastroenteroloji. 10:3 Eylül 2006.273-276
• 47- Kumar et al. Putative probiotic Lactobacillus spp. from porcine gastrointestinal tract inhibit transmissible gastroenteritis coronavirus and enteric bacterial pathogens.Trop Anim Health Prod 2010;42(8) 1855–1860.
• 48- Costa R. L, et al. Infectious complications following probiotic ingestion: a potentially underestimated problem? A systematic review of reports and case series. BMC Complement Altern Med 2018; 18: 329.
• 49- Akdis M, O’Mahony. Prebiotics, probiotics, synbiotics, and the immune system: experimental data and clinical evidence. Current Opinion in Gastroenterology 2015;31(2):153–158.
• 50- İnanç N, Şahin H, Çiçek B. Probiyotik ve Prebiyotiklerin sağlık Üzerine Etkileri. ErciyesTıpDergisi 2005;27(3):122-127.
• 51- Yağcı R. Prebiyotikler ve Probiyotikler. Çocuk Sağlığı ve Hastalıkları Dergisi 2002:45(4):337-344.
• 52- Gupta P, et al. Is Lactobacillus GG helpful in children with Crohn’s disease? Results of a preliminary, open –label study. J.Pediatr Gastroenterol Nutr 2000;31:453-457
• 53- Madsen K. Inflammatory bowel disease .Lessons from the IL-10 gene-deficient Mouse .Clin Invest Med 2001:24; 250-257 54- Doğan M. Probiyotik bakterilerin etki mekanizması. ABMYO Dergisi 2011;21:98-102.
• 55- Ghoneum M, Gimzewski J.Apoptotic effect of a novel kefir product, PFT, on multidrug-resistant myeloid leukemia cells via a hole-piercing mechanism. Int J Oncol. 2014;44(3):830-7.
• 56- Ghoneum M, Felo N. Selective induction of apoptosis in human gastric cancer cells by Lactobacillus kefiri (PFT), a novel kefir product. Oncol Rep 2015;34(4):1659-66. 57- Slattery C, Cotter PD, O’Tolee WP. Analysis of Health Benefits Conferred by Lactobacillus Species from Kefir. Nutrients 2019;11(6):1252.
• 58- Li-Juan Yi, et al. Early enteral nutrition supplemented with probiotics improved the clinical outcomes in severe head injury. Medicine (Baltimore). 2019;98(17):e15426.
• 59- Gu WJ, et al. The effects of probiotics in early enteral nutrition on the outcomes of trauma: a meta-analysis of randomized controlled trials. JPEN J Parenter Enteral Nutr 2013;37:310–7.