Evaluation of Renal and Thyroid Function Tests in Chronic Renal Failure Patients
Abstract
It is known that the kidney normally plays an important role in the metabolism, degradation and excretion of several thyroid hormones. Accordingly, deterioration in renal function is expected to lead to disturbing thyroid physiology. In the study, we aimed to investigate the effect of a single hemodialysis session on thyroid function in patients with chronic renal failure that have hemodialysis treatment, and also to compare thyroid function tests and some biochemical parameters in hemodialysis patients with healthy groups. We collected blood samples which were drawn pre- and after-dialysis sessions from 29 patients (mean age: 46.17 ± 14.93) and 28 healthy participants (mean age: 40.79 ± 14.42) as control group, and analysed using an autoanalyzer followed by statistical analysis. TT4, FT3 and FT4 values were found statistically significant (p < 0.01, p < 0.05 and p < 0.05, respectively) in comparison of pre- and post-dialysis samples. Also, the findings of the study revealed that there was a significant difference only among the parameters of TT3 (p < 0.01), FT3 (p < 0.001) and TSH (p < 0.05) for the healthy participants and dialysis group in spite of any statistically significance was not detected in the values of TT3 and TSH parameters of the same group (p > 0.1). In addition, statistical results proved that creatinine - FT4 values (p < 0.01) in the pre-dialysis group and creatinine - urea values in the post-dialysis group (p < 0.001) were correlated positively. We evaluated the significance of the thyroid function tests during the diagnosis of thyroid disorders in patients with chronic kidney failure in the present study and found that thyroid function tests could be crucial for the treatment of hemodialysis patients.
Keywords
Chronic renal failure , Hemodialysis , Thyroid function tests
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