Determination of Paracetamol with Histamine Modified Multi-Walled Carbon Nanotube/Coal Tar Pitch/Pencil Graphite Electrode

Year 2024, Volume: 6 Issue: 3, 557 - 565, 31.12.2024

Şeyma Korkmaz , İbrahim Ender Mülazımoglu , Ayşen Demir Mülazımoğlu

https://doi.org/10.47112/neufmbd.2024.65

Abstract

IIn this study for the determination of Paracetamol (PAR), Histamine (HI) was used by modifying the surface of multiwalled carbon nanotube/ coal tar pitch/pencil graphite electrode (MWCNT/CTP/PGE) for the first time. Cyclic voltammetry (CV) experiments for the modification of HI on MWCNT/CTP/PGE were carried out in the potential range of +0.8 V to +1.8 V, at a scan rate of 100 mV s-1 with 20 cycles. The electrochemical behaviours of the obtained HI/MWCNT/CTP/PGE electrochemical sensor were characterized by CV in aqueous and non-aqueous medias. The modified electrode was imaged with the scanning electron microscope (SEM) technique and compared with MWCNT/CTP/PGE. Britton-Robinson (BR) buffer solution, prepared at different pHs using the square wave voltammetry (SWV) technique was used as a supporting electrolyte. The optimum pH for PAR determination using the SWV technique was determined as 2.00. A calibration graph was drawn with standard PAR solutions prepared in pH 2.00 BR buffer between 2x10-5 and 2x10-6 M using the SWV technique, with a correlation coefficient (R2) calculated as 0.9991. The limit of detection (LOD) and limit of quantification (LOQ) for PAR were calculated as 0.498 µM and 1.494 µM, respectively. The proposed method is easy to implement, low cost, fast, simple and reliable.

Keywords

Paracetamol, Histamine, Modification, Pencil graphite electrode, Square wave voltammetry

Supporting Institution

Research Foundation of Necmettin Erbakan University

Project Number

BAP-23DR10002

Histamin Modifiye Çok Duvarlı Karbon Nanotüp/Katran/Kalem Grafit Elektrot ile Parasetamol Tayini

Abstract

Bu çalışmada Parasetamol (PAR) tayini için ilk kez Histamin (HI), çok duvarlı karbon nanotüp/kömür katranı/kalem grafit elektrot (MWCNT/CTP/PGE) yüzeyine modifiye edilerek kullanıldı. MWCNT/CTP/PGE üzerine HI’nın modifikasyonu için dönüşümlü voltametri (CV) deneyleri, +0,8 V ile +1,8 V potansiyel aralığında, 100 mV s-1 tarama hızında ve 20 döngülü olarak gerçekleştirildi. Elde edilen HI/MWCNT/CTP/PGE elektrokimyasal sensörün elektrokimyasal davranışları sulu ve susuz ortamlarda CV ile karakterize edildi. Modifiye elektrotun taramalı elektron mikroskobu (SEM) tekniği ile görüntüsü alındı ve MWCNT/CTP/PGE ile kıyaslandı. Kare dalga voltametri (SWV) tekniği ile farklı pH’larda hazırlanan Britton-Robinson (BR) tampon çözeltisi destek elektrolit olarak kullanıldı. SWV tekniği kullanılarak PAR tayini için optimum pH 2,00 olarak belirlendi. SWV tekniği ile 2x10-5 ile 2x10-6 M aralığında pH 2,00 BR tamponunda hazırlanan standart PAR çözeltileri ile korelasyon katsayısı (R2) 0,9991 olarak hesaplanan kalibrasyon grafiği çizildi. PAR için gözlenebilirlik sınırı (LOD) ve tayin sınırı (LOQ) sırasıyla 0,498 µM ve 1,494 µM olarak hesaplandı. Önerilen yöntem, uygulanabilirliği kolay, maliyeti düşük, hızlı, basit ve güvenilirdir.

Keywords

Parasetamol, Histamin, Modifikasyon, Kalem grafit elektrot, Kare dalga voltametri

Supporting Institution

Necmettin Erbakan Üniversitesi

Project Number

BAP-23DR10002

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